Mary Bartlett Bunge
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View article: Phase 1 Safety Trial of Autologous Human Schwann Cell Transplantation in Chronic Spinal Cord Injury
Phase 1 Safety Trial of Autologous Human Schwann Cell Transplantation in Chronic Spinal Cord Injury Open
A phase 1 open-label, non-randomized clinical trial was conducted to determine feasibility and safety of autologous human Schwann cell (ahSC) transplantation accompanied by rehabilitation in participants with chronic spinal cord injury (SC…
View article: Imaging characteristics of chronic spinal cord injury identified during screening for a cell transplantation clinical trial
Imaging characteristics of chronic spinal cord injury identified during screening for a cell transplantation clinical trial Open
OBJECTIVE In cell transplantation trials for spinal cord injury (SCI), quantifiable imaging criteria that serve as inclusion criteria are important in trial design. The authors’ institutional experience has demonstrated an overall high rat…
View article: Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination <i>in vitro</i>
Aligned fibrous PVDF-TrFE scaffolds with Schwann cells support neurite extension and myelination <i>in vitro</i> Open
This study demonstrated PVDF-TrFE scaffolds containing aligned fibers supported SC-neurite extension and myelination. The combination of SCs and PVDF-TrFE scaffolds may be a promising tissue engineering strategy for spinal cord repair.
View article: Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap
Transplantation of Schwann Cells Inside PVDF-TrFE Conduits to Bridge Transected Rat Spinal Cord Stumps to Promote Axon Regeneration Across the Gap Open
Among various models for spinal cord injury in rats, the contusion model is the most often used because it is the most common type of human spinal cord injury. The complete transection model, although not as clinically relevant as the cont…
View article: Overexpression of the Fibroblast Growth Factor Receptor 1 (FGFR1) in a Model of Spinal Cord Injury in Rats
Overexpression of the Fibroblast Growth Factor Receptor 1 (FGFR1) in a Model of Spinal Cord Injury in Rats Open
Spinal cord injury (SCI) is a severe condition that affects many people and results in high health care costs. Therefore, it is essential to find new targets for treatment. The fibroblast growth factor receptor 1 (FGFR1) signalling pathway…
View article: Efficacy of Schwann cell transplantation for spinal cord repair is improved with combinatorial strategies
Efficacy of Schwann cell transplantation for spinal cord repair is improved with combinatorial strategies Open
When cells (including Schwann cells; SCs) of the peripheral nervous system (PNS) could be purified and expanded in number in tissue culture, Richard Bunge in 1975 envisioned that the SCs could be introduced to repair the central nervous sy…
View article: Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model
Transcriptional changes in sensory ganglia associated with primary afferent axon collateral sprouting in spared dermatome model Open
Primary afferent collateral sprouting is a process whereby non-injured primary afferent neurons respond to some stimulus and extend new branches from existing axons. Neurons of both the central and peripheral nervous systems undergo this p…
View article: Systemic administration of epothilone B promotes axon regeneration after spinal cord injury
Systemic administration of epothilone B promotes axon regeneration after spinal cord injury Open
Progress toward fixing a broken back? Axon regeneration after a spinal cord injury requires interference with neuronal mechanisms to promote axon extension and early suppression of scar formation. Microtubule stabilization could provide, i…
View article: MASH1/Ascl1a Leads to GAP43 Expression and Axon Regeneration in the Adult CNS
MASH1/Ascl1a Leads to GAP43 Expression and Axon Regeneration in the Adult CNS Open
Unlike CNS neurons in adult mammals, neurons in fish and embryonic mammals can regenerate their axons after injury. These divergent regenerative responses are in part mediated by the growth-associated expression of select transcription fac…