Catherine M. Kerr
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View article: An Autoimmunity-associated allele of <i>PTPN22</i> enhances innate antiviral immunity to protect against acute coronavirus infection
An Autoimmunity-associated allele of <i>PTPN22</i> enhances innate antiviral immunity to protect against acute coronavirus infection Open
Allelic variation can impact viral clearance and disease severity. Still, our understanding of the effect of the autoimmunity-associated allelic variant of Ptpn22 (PEP-R619W) on antiviral immunity remains incomplete, as previous reports ha…
View article: IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice
IFN-γ signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice Open
Neurotropic viruses are a major public health concern as they can cause encephalitis and other severe brain diseases. Many of these viruses, including flaviviruses, herpesviruses, rhabdoviruses and alphaviruses enter the brain through the …
View article: Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle
Mutations differentially affecting the coronavirus Mac1 ADP-ribose binding and hydrolysis activities indicate that it promotes multiple stages of the viral replication cycle Open
All coronaviruses (CoVs) encode a conserved macrodomain, termed Mac1, in non-structural protein 3 (nsp3) that binds and hydrolyzes ADP-ribose covalently attached to proteins. Mac1 is a key virulence factor that counters antiviral ADP-ribos…
View article: IFN-<i>γ</i>signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice
IFN-<i>γ</i>signaling is required for the efficient replication of murine hepatitis virus (MHV) strain JHM in the brains of infected mice Open
Neurotropic viruses are a major public health concern as they can cause encephalitis and other severe brain diseases. Many of these viruses, including flaviviruses, herpesviruses, rhabdoviruses and alphaviruses enter the brain through the …
View article: Mutation of a highly conserved isoleucine residue in loop 2 of several 𝛽-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection
Mutation of a highly conserved isoleucine residue in loop 2 of several 𝛽-coronavirus macrodomains indicates that enhanced ADP-ribose binding is detrimental to infection Open
All coronaviruses (CoVs) encode for a conserved macrodomain (Mac1) located in nonstructural protein 3 (nsp3). Mac1 is an ADP-ribosylhydrolase that binds and hydrolyzes mono-ADP-ribose from target proteins. Previous work has shown that Mac1…
View article: PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell- and tissue-specific manner Open
ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD + to protein or nucleic acid substrates. This modification can be removed by several different types of proteins, including macrodomains. Several ARTs, also known a…
View article: SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in cell culture and in mice Open
Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in these drug targets is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein en…
View article: PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner
PARP12 is required to repress the replication of a Mac1 mutant coronavirus in a cell and tissue specific manner Open
ADP-ribosyltransferases (ARTs) mediate the transfer of ADP-ribose from NAD + to protein or nucleic acid substrates. This modification can be removed by several different types of proteins, including macrodomains. Several ARTs, also known a…
View article: SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice
SARS-CoV-2 Mac1 is required for IFN antagonism and efficient virus replication in mice Open
Several coronavirus (CoV) encoded proteins are being evaluated as targets for antiviral therapies for COVID-19. Included in this set of proteins is the conserved macrodomain, or Mac1, an ADP-ribosylhydrolase and ADP-ribose binding protein.…
View article: Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication
Unique Mutations in the Murine Hepatitis Virus Macrodomain Differentially Attenuate Virus Replication, Indicating Multiple Roles for the Macrodomain in Coronavirus Replication Open
In the wake of the COVID-19 epidemic, there has been a surge to better understand how CoVs replicate and to identify potential therapeutic targets that could mitigate disease caused by SARS-CoV-2 and other prominent CoVs. The highly conser…
View article: An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication
An MHV macrodomain mutant predicted to lack ADP-ribose binding activity is severely attenuated, indicating multiple roles for the macrodomain in coronavirus replication Open
All coronaviruses (CoVs) contain a macrodomain, also termed Mac1, in non-structural protein 3 (nsp3) which binds and hydrolyzes ADP-ribose covalently attached to proteins. Despite several reports demonstrating that Mac1 is a prominent viru…
View article: The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions
The impact of PARPs and ADP-ribosylation on inflammation and host–pathogen interactions Open
Poly-adenosine diphosphate-ribose polymerases (PARPs) promote ADP-ribosylation, a highly conserved, fundamental posttranslational modification (PTM). PARP catalytic domains transfer the ADP-ribose moiety from NAD + to amino acid residues o…
View article: Three new coccidians (Cyclospora, Eimeria) from eastern moles, Scalopus aquaticus (Linnaeus) (Mammalia: Soricomorpha: Talpidae) from Arkansas, USA
Three new coccidians (Cyclospora, Eimeria) from eastern moles, Scalopus aquaticus (Linnaeus) (Mammalia: Soricomorpha: Talpidae) from Arkansas, USA Open
View article: A new eimerian (Apicomplexa: Eimeriidae), from ornate box turtle, Terrapene ornata (Agassiz) (Testudines: Emydidae) from northwest Arkansas, USA
A new eimerian (Apicomplexa: Eimeriidae), from ornate box turtle, Terrapene ornata (Agassiz) (Testudines: Emydidae) from northwest Arkansas, USA Open