Mary Claire Tuohy
YOU?
Author Swipe
View article: Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke
Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke Open
The integrity of adherens and tight junctions is critical for blood-brain barrier (BBB) function in the healthy brain. Disassembly of cell junctions due to degradation of adherens and tight junction-associated proteins leads to acute BBB d…
View article: Endothelial Type I Interferon signaling modulates the vascular response to ischemic brain injury
Endothelial Type I Interferon signaling modulates the vascular response to ischemic brain injury Open
Vascular normalization [stabilization of aberrant angiogenesis and restoration of blood-brain barrier (BBB)] is critical for reducing long-term secondary sequelae after ischemic stroke. How immune and developmental signaling pathways coord…
View article: Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke
Rab7a is required to degrade select blood-brain barrier junctional proteins after ischemic stroke Open
SUMMARY Adherens (AJ) and tight junction (TJ) integrity is critical for blood-brain barrier (BBB) function in the healthy brain. Junction disassembly due to degradation of AJ and TJ proteins leads to acute BBB dysfunction after ischemic st…
View article: The age-dependent immune response to ischemic stroke
The age-dependent immune response to ischemic stroke Open
View article: Single-cell RNA-sequencing implicates venous endothelial cells as a source of VEGF-A-mediated neo-angiogenesis in neuroinflammation
Single-cell RNA-sequencing implicates venous endothelial cells as a source of VEGF-A-mediated neo-angiogenesis in neuroinflammation Open
Histopathological studies of multiple sclerosis (MS), a demyelinating disease of the central nervous system (CNS), and its animal model, experimental autoimmune encephalomyelitis (EAE), have found newly formed leaky vessels in demyelinated…
View article: Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury
Neurovascular dynamics of repeated cortical spreading depolarizations after acute brain injury Open
Cortical spreading depolarizations (CSDs) are increasingly suspected to play an exacerbating role in a range of acute brain injuries, including stroke, possibly through their interactions with cortical blood flow. We use simultaneous wide-…
View article: Obesity is independently associated with septic shock, renal complications, and mortality in a multiracial patient cohort hospitalized with COVID-19
Obesity is independently associated with septic shock, renal complications, and mortality in a multiracial patient cohort hospitalized with COVID-19 Open
Background Obesity has emerged as a risk factor for severe coronavirus disease 2019 (COVID-19) infection. To inform treatment considerations the relationship between obesity and COVID-19 complications and the influence of race, ethnicity, …
View article: Clinical and electrographic features of persistent seizures and status epilepticus associated with anti‐NMDA receptor encephalitis (anti‐NMDARE)
Clinical and electrographic features of persistent seizures and status epilepticus associated with anti‐NMDA receptor encephalitis (anti‐NMDARE) Open
Aims . Based on a multicenter cohort of people with anti‐NMDA receptor encephalitis (anti‐NMDARE), we describe seizure phenotypes, electroencephalographic (EEG) findings, and anti‐seizure treatment strategies. We also investigated whether …
View article: Outcomes of exclusive enteral nutrition in paediatric Crohn’s disease
Outcomes of exclusive enteral nutrition in paediatric Crohn’s disease Open