Mary E Faulkner
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View article: Age-related differences in Rostral-Middle locus coeruleus microstructure: A critical role in cognitive decline revealed by magnetic resonance relaxometry
Age-related differences in Rostral-Middle locus coeruleus microstructure: A critical role in cognitive decline revealed by magnetic resonance relaxometry Open
Background The Locus Coeruleus (LC) is a critical brain region affected by neurodegenerative diseases and aging. Despite its importance, in-vivo investigations of age-related LC degeneration and association with cognitive decline have been…
View article: Machine learning diagnosis of mild cognitive impairment using advanced diffusion MRI and CSF biomarkers
Machine learning diagnosis of mild cognitive impairment using advanced diffusion MRI and CSF biomarkers Open
INTRODUCTION Machine learning applied to neuroimaging can help with medical diagnosis and early detection by identifying biomarkers of subtle changes in brain structure and function. The effectiveness of advanced diffusion MRI (dMRI) metho…
View article: Network segregation is associated with processing speed in the cognitively healthy oldest-old
Network segregation is associated with processing speed in the cognitively healthy oldest-old Open
The brain is organized into systems and networks of interacting components. The functional connections among these components give insight into the brain’s organization and may underlie some cognitive effects of aging. Examining the relati…
View article: Machine Learning Classification of Mild Cognitive Impairment using Advanced Multi-Shell Diffusion MRI and CSF Biomarkers
Machine Learning Classification of Mild Cognitive Impairment using Advanced Multi-Shell Diffusion MRI and CSF Biomarkers Open
INTRODUCTION: Machine learning applied to neuroimaging can help with medical diagnosis and early detection by identifying biomarkers of subtle changes in brain structure and function. The effectiveness of advanced diffusion MRI (dMRI) imag…
View article: Age-related differences in Rostral-Middle Locus Coeruleus Microstructure: A Critical Role in Cognitive Decline Revealed by Magnetic Resonance Relaxometry
Age-related differences in Rostral-Middle Locus Coeruleus Microstructure: A Critical Role in Cognitive Decline Revealed by Magnetic Resonance Relaxometry Open
BACKGROUND The Locus Coeruleus (LC) is a critical brain region affected by neurodegenerative diseases and cognitive decline in aging. Despite its importance, in-vivo investigations of age-related LC degeneration and association with cognit…
View article: Investigating the association between human brainstem microstructural integrity and hypertension using magnetic resonance relaxometry
Investigating the association between human brainstem microstructural integrity and hypertension using magnetic resonance relaxometry Open
View article: Cortical Myelination, Cognition, and Cardiovascular Fitness: New Insights using Advanced Magnetic Resonance Relaxometry
Cortical Myelination, Cognition, and Cardiovascular Fitness: New Insights using Advanced Magnetic Resonance Relaxometry Open
Background Alterations in grey matter (GM) are known to contribute to cognitive decline in aging and dementia. Recent evidence suggests that individuals with higher cardiorespiratory fitness (CRF) may have a lower risk of GM atrophy and su…
View article: Widespread neurite degeneration in mild cognitive impairment and Alzheimer’s disease revealed using advanced diffusion MRI
Widespread neurite degeneration in mild cognitive impairment and Alzheimer’s disease revealed using advanced diffusion MRI Open
Background Neurite degeneration is increasingly suspected to represent a causal feature of mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Therefore, sensitive and specific imaging biomarkers of neuronal degeneration are need…
View article: PhysicOmics: Combining MR physics, proteomics, and transcriptomics to study cerebral aging and neurodegeneration
PhysicOmics: Combining MR physics, proteomics, and transcriptomics to study cerebral aging and neurodegeneration Open
Background Neuroimaging‐based evidence suggests that changes in cerebral tissue determinants, including axonal density and myelin content, are associated with aging and neurodegenerative diseases. While neuroimaging markers show strong ass…
View article: White Matter, Aging, and Cognition: New Insights Using Advanced MR Relaxometry and Symmetric Data‐driven Fusion
White Matter, Aging, and Cognition: New Insights Using Advanced MR Relaxometry and Symmetric Data‐driven Fusion Open
Background Cognitive decline during normative aging significantly impacts the quality of life, while the rate varies among individuals. MRI studies have highlighted the correlation between cognitive functions and brain macrostructure. Howe…
View article: Cortical Myelination, Cognition, and Cardiovascular Fitness: New Insights using Advanced Magnetic Resonance Relaxometry
Cortical Myelination, Cognition, and Cardiovascular Fitness: New Insights using Advanced Magnetic Resonance Relaxometry Open
Background Alterations in grey matter (GM) are known to contribute to cognitive decline in aging and dementia. Recent evidence suggests that individuals with higher cardiorespiratory fitness (CRF) may have a lower risk of GM atrophy and su…
View article: Myelin water imaging with clinically feasible scan time: The accelerated BMC‐mcDESPOT (aBMC‐mcDESPOT) method
Myelin water imaging with clinically feasible scan time: The accelerated BMC‐mcDESPOT (aBMC‐mcDESPOT) method Open
Background In 2016, we introduced the Bayesian Monte Carlo analysis of multicomponent‐driven equilibrium observation of T 1 and T 2 (BMC‐mcDESPOT) MRI method for myelin water fraction (MWF) mapping, a surrogate of myelin content. While BMC…
View article: Associations Between Choroid Plexus Integrity and Cognitive Decline in Aging: Insights from Advanced MRI Analysis
Associations Between Choroid Plexus Integrity and Cognitive Decline in Aging: Insights from Advanced MRI Analysis Open
Background The choroid plexus (CP), a vital component in the brain's ventricles, is crucial for cerebrospinal fluid (CSF) production and maintenance of the brain's physiological environment. It plays a key role in regulating neuroinflammat…
View article: Associations Between Choroid Plexus Integrity and Cognitive Decline in Aging: Insights from Advanced MRI Analysis
Associations Between Choroid Plexus Integrity and Cognitive Decline in Aging: Insights from Advanced MRI Analysis Open
Background The choroid plexus (CP), a vital component in the brain’s ventricles, is crucial for cerebrospinal fluid (CSF) production and maintenance of the brain’s physiological environment. It plays a key role in regulating neuroinflammat…
View article: Higher cardiorespiratory fitness is associated with higher cerebral myelination in normative aging
Higher cardiorespiratory fitness is associated with higher cerebral myelination in normative aging Open
Background Age‐related white matter (WM) deterioration has been associated with several neurodegenerative diseases, including Alzheimer’s disease. Studies suggest that cardiorespiratory fitness (CRF) is important in preserving WM structure…
View article: PhysicOmics: Combining MR physics, proteomics, and transcriptomics to study cerebral aging and neurodegeneration
PhysicOmics: Combining MR physics, proteomics, and transcriptomics to study cerebral aging and neurodegeneration Open
Background Neuroimaging‐based evidence suggests that changes in cerebral tissue determinants, including axonal density and myelin content, are associated with aging and neurodegenerative diseases. While neuroimaging markers show strong ass…
View article: Myelin water imaging with clinically feasible scan time: the accelerated BMC‐mcDESPOT (aBMC‐mcDESPOT) method
Myelin water imaging with clinically feasible scan time: the accelerated BMC‐mcDESPOT (aBMC‐mcDESPOT) method Open
Background In 2016, we introduced the Bayesian Monte Carlo analysis of multicomponent‐driven equilibrium observation of T1 and T2 (BMC‐mcDESPOT) MRI method for myelin water fraction (MWF) mapping, a surrogate of myelin content. While BMC‐m…
View article: Widespread neurite degeneration in mild cognitive impairment and Alzheimer's disease revealed using advanced diffusion MRI
Widespread neurite degeneration in mild cognitive impairment and Alzheimer's disease revealed using advanced diffusion MRI Open
Background Neurite degeneration is increasingly suspected to represent a causal feature of mild cognitive impairment (MCI) and Alzheimer's disease (AD). Therefore, sensitive and specific imaging biomarkers of neuronal degeneration are need…
View article: White Matter, Aging, and Cognition: New Insights Using Advanced MR Relaxometry and Symmetric Data‐driven Fusion
White Matter, Aging, and Cognition: New Insights Using Advanced MR Relaxometry and Symmetric Data‐driven Fusion Open
Background Cognitive decline during normative aging significantly impacts the quality of life, while the rate varies among individuals. MRI studies have highlighted the correlation between cognitive functions and brain macrostructure. Howe…
View article: White matter integrity and motor function: a link between cerebral myelination and longitudinal changes in gait speed in aging
White matter integrity and motor function: a link between cerebral myelination and longitudinal changes in gait speed in aging Open
View article: Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review
Harnessing myelin water fraction as an imaging biomarker of human cerebral aging, neurodegenerative diseases, and risk factors influencing myelination: A review Open
Myelin water fraction (MWF) imaging has emerged as a promising magnetic resonance imaging (MRI) biomarker for investigating brain function and composition. This comprehensive review synthesizes the current state of knowledge on MWF as a bi…
View article: 61 Network Segregation Predicts Processing Speed in the Cognitively Healthy Oldest-old
61 Network Segregation Predicts Processing Speed in the Cognitively Healthy Oldest-old Open
Objective: Understanding the factors contributing to optimal cognitive function throughout the aging process is essential to better understand successful cognitive aging. Processing speed is an age sensitive cognitive domain that usually d…
View article: The Effect of the Human Brainstem Myelination on Gait Speed in Normative Aging
The Effect of the Human Brainstem Myelination on Gait Speed in Normative Aging Open
The brainstem functions as a relay and integrative brain center and plays an essential role in motor function. Whether brainstem tissue deterioration, including demyelination, affects motor function has not been studied. Understanding the …
View article: C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter
C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter Open
Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of neurite density and dispersion through computation of the neurite density index (NDI) and the orientation dispersion index (ODI). However, NODDI overes…
View article: Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study
Hypertensive Adults Exhibit Lower Myelin Content: A Multicomponent Relaxometry and Diffusion Magnetic Resonance Imaging Study Open
BACKGROUND: It is unknown whether hypertension plays any role in cerebral myelination. To fill this knowledge gap, we studied 90 cognitively unimpaired adults, age range 40 to 94 years, who are participants in the Baltimore Longitudinal St…
View article: Investigation of the association between central arterial stiffness and aggregate g-ratio in cognitively unimpaired adults
Investigation of the association between central arterial stiffness and aggregate g-ratio in cognitively unimpaired adults Open
Stiffness of the large arteries has been shown to impact cerebral white matter (WM) microstructure in both younger and older adults. However, no study has yet demonstrated an association between arterial stiffness and aggregate g -ratio, a…
View article: C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter in normative aging
C-NODDI: a constrained NODDI model for axonal density and orientation determinations in cerebral white matter in normative aging Open
Purpose Neurite orientation dispersion and density imaging (NODDI) provides measures of neurite density and dispersion through computation of the neurite density index (NDI) and the orientation dispersion index (ODI). However, NODDI overes…
View article: Lower Myelin Content Is Associated With Lower Gait Speed in Cognitively Unimpaired Adults
Lower Myelin Content Is Associated With Lower Gait Speed in Cognitively Unimpaired Adults Open
Mounting evidence indicates that abnormal gait speed predicts the progression of neurodegenerative diseases, including Alzheimer’s disease. Understanding the relationship between white matter integrity, especially myelination, and motor fu…
View article: Hypertensive adults exhibit lower myelin content: A multicomponent relaxometry and diffusion MRI study
Hypertensive adults exhibit lower myelin content: A multicomponent relaxometry and diffusion MRI study Open
It is unknown whether hypertension plays any role in cerebral myelination. To fill this knowledge gap, we studied ninety cognitively unimpaired adults, age range 40 to 94 years, that are participants in the Baltimore Longitudinal Study of …
View article: <scp>MRI</scp> and fluid biomarkers reveal determinants of myelin and axonal loss with aging
<span>MRI</span> and fluid biomarkers reveal determinants of myelin and axonal loss with aging Open
Objective White matter damage is a feature of Alzheimer's disease, yet little is known about how facets of the Alzheimer's disease process relate to key features of white matter structure. We examined the association of Alzheimer's disease…