Mary E. Lassaline
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View article: Clinical and morphological features of corneal lymphoma in 26 horses (27 eyes)
Clinical and morphological features of corneal lymphoma in 26 horses (27 eyes) Open
Background Little information describing the biologic behaviour and therapies for corneal lymphoma exist. Objectives To characterise histologically confirmed equine corneal lymphoma considering breed, age or sex predisposition, histologic …
View article: Ultrasound biomicroscopy of the equine iridocorneal angle
Ultrasound biomicroscopy of the equine iridocorneal angle Open
Background The iridocorneal angle (ICA) is the major pathway of aqueous humour outflow from the anterior chamber of the eye. Ultrasound biomicroscopy (UBM) has been utilised to characterise the morphology of this drainage pathway in numero…
View article: Corneal thickness and anterior chamber depth of the normal adult horse as measured by ultrasound biomicroscopy
Corneal thickness and anterior chamber depth of the normal adult horse as measured by ultrasound biomicroscopy Open
Objective To determine corneal thickness (CT) and axial anterior chamber depth (ACD) using ultrasound biomicroscopy (UBM) in normal adult horses. To compare corneal thickness measurements between UBM and ultrasonic pachymetry. Animals stud…
View article: Whole genome sequencing identified a 16 kilobase deletion on ECA13 associated with distichiasis in Friesian horses
Whole genome sequencing identified a 16 kilobase deletion on ECA13 associated with distichiasis in Friesian horses Open
Background Distichiasis, an ocular disorder in which aberrant cilia (eyelashes) grow from the opening of the Meibomian glands of the eyelid, has been reported in Friesian horses. These misplaced cilia can cause discomfort, chronic keratiti…
View article: Additional Evidence for<i>DDB2</i>T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses
Additional Evidence for<i>DDB2</i>T338M as a Genetic Risk Factor for Ocular Squamous Cell Carcinoma in Horses Open
Squamous cell carcinoma (SCC) is the most common periocular cancer in horses and the second most common tumor of the horse overall. A missense mutation in damage-specific DNA-binding protein 2 ( DDB2 , c.1012 C > T , p.Thr338Met) was previ…
View article: Horses with equine recurrent uveitis have an activated CD4+ T‐cell phenotype that can be modulated by mesenchymal stem cells in vitro
Horses with equine recurrent uveitis have an activated CD4+ T‐cell phenotype that can be modulated by mesenchymal stem cells in vitro Open
Equine recurrent uveitis (ERU) is an immune‐mediated disease causing repeated or persistent inflammatory episodes which can lead to blindness. Currently, there is no cure for horses with this disease. Mesenchymal stem cells (MSCs) are effe…
View article: Equine eosinophilic keratoconjunctivitis in California: retrospective study of 47 eyes from 29 cases (1993‐2017)
Equine eosinophilic keratoconjunctivitis in California: retrospective study of 47 eyes from 29 cases (1993‐2017) Open
Objective (a) To evaluate the epidemiology of equine eosinophilic keratoconjunctivitis ( EK ) in the western United States, (b) to ascertain the efficacy of keratectomy and diamond burr debridement vs medical management alone, (c) to deter…
View article: Generation of an equine biobank to be used for Functional Annotation of Animal Genomes project
Generation of an equine biobank to be used for Functional Annotation of Animal Genomes project Open
Summary The Functional Annotation of Animal Genomes ( FAANG ) project aims to identify genomic regulatory elements in both sexes across multiple stages of development in domesticated animals. This study represents the first stage of the FA…
View article: Ruling out <i><scp>BGN</scp></i> variants as simple X‐linked causative mutations for bilateral corneal stromal loss in Friesian horses
Ruling out <i><span>BGN</span></i> variants as simple X‐linked causative mutations for bilateral corneal stromal loss in Friesian horses Open
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View article: Traumatic phacocele in an American Miniature Horse
Traumatic phacocele in an American Miniature Horse Open
An 18‐year‐old American Miniature Horse mare was presented with a complaint of a scleral swelling affecting the right eye and a history of suspected trauma 6 weeks prior to evaluation. Clinical findings included severe blepharospasm, a bul…
View article: Effects of 0.2% brimonidine and 0.2% brimonidine–0.5% timolol on intraocular pressure and pupil size in normal equine eyes
Effects of 0.2% brimonidine and 0.2% brimonidine–0.5% timolol on intraocular pressure and pupil size in normal equine eyes Open
Summary Background Brimonidine is an α 2 ‐adrenergic agonist that decreases aqueous humour production and may increase uveoscleral outflow. It has not been evaluated in normal or glaucomatous equine eyes. Objectives To evaluate the efficac…
View article: A missense mutation in damage‐specific DNA binding protein 2 is a genetic risk factor for limbal squamous cell carcinoma in horses
A missense mutation in damage‐specific DNA binding protein 2 is a genetic risk factor for limbal squamous cell carcinoma in horses Open
Squamous cell carcinoma (SCC) is the most common cancer of the equine eye, frequently originating at the limbus, with the potential to invade the cornea, cause visual impairment, and result in loss of the eye. Several breeds of horses have…
View article: A promising surgical approach to equine glaucoma
A promising surgical approach to equine glaucoma Open
Summary The preceding case report by Wilson et al . (2015) describes the surgical placement of a B aerveldt glaucoma shunt in a glaucomatous equine eye that had been refractory to aggressive medical and repeated surgical therapies yet main…