Mary E. Marquart
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View article: Characterization of Expulsion, Cell Viability, and Bacterial Attachment of Enhanced Sulfonated Hydrothermally Treated PEEK Surfaces for Implant Applications
Characterization of Expulsion, Cell Viability, and Bacterial Attachment of Enhanced Sulfonated Hydrothermally Treated PEEK Surfaces for Implant Applications Open
Porosity and roughened surfaces of implant materials have been shown to lead to improved cellular attachment and enhanced osseointegration. These topography changes in the surface also aid in the mechanical interlocking of the material to …
View article: Phosphorus-and-Silver-Doped Crystalline Oxide Coatings for Titanium Implant Surfaces
Phosphorus-and-Silver-Doped Crystalline Oxide Coatings for Titanium Implant Surfaces Open
Bacteria-related infections remain a leading cause of dental implant failures. Despite the successful history of titanium implants, naturally forming oxides lack antibacterial properties. Crystalline oxides, modified through anodization pr…
View article: Silver-Doped Titanium Oxide Layers for Improved Photocatalytic Activity and Antibacterial Properties of Titanium Implants
Silver-Doped Titanium Oxide Layers for Improved Photocatalytic Activity and Antibacterial Properties of Titanium Implants Open
Titanium has a long history of clinical use, but the naturally forming oxide is not ideal for bacterial resistance. Anodization processes can modify the crystallinity, surface topography, and surface chemistry of titanium oxides. Anatase, …
View article: Photocatalytic Activity and Antibacterial Properties of Mixed-Phase Oxides on Titanium Implant Alloy Substrates
Photocatalytic Activity and Antibacterial Properties of Mixed-Phase Oxides on Titanium Implant Alloy Substrates Open
Titanium alloys are commonly used for implants, but the naturally forming oxides are bioinert and not ideal for bacterial resistance or osseointegration. Anodization processes are a modification technique that can crystallize the oxides, a…
View article: Radio frequency heating of washable conductive textiles for bacteria and virus inactivation
Radio frequency heating of washable conductive textiles for bacteria and virus inactivation Open
The ongoing COVID-19 pandemic has increased the use of single-use medical fabrics such as surgical masks, respirators, and other personal protective equipment (PPE), which have faced worldwide supply chain shortages. Reusable PPE is desira…
View article: Synthesis and Inhibitory Activity of Machaeridiol-Based Novel Anti-MRSA and Anti-VRE Compounds and Their Profiling for Cancer-Related Signaling Pathways
Synthesis and Inhibitory Activity of Machaeridiol-Based Novel Anti-MRSA and Anti-VRE Compounds and Their Profiling for Cancer-Related Signaling Pathways Open
Three unique 5,6-seco-hexahydrodibenzopyrans (seco-HHDBP) machaeridiols A–C, reported previously from Machaerium Pers., have displayed potent activities against methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enter…
View article: Absence of Streptococcus pneumoniae Capsule Increases Bacterial Binding, Persistence, and Inflammation in Corneal Infection
Absence of Streptococcus pneumoniae Capsule Increases Bacterial Binding, Persistence, and Inflammation in Corneal Infection Open
The role of the pneumococcal polysaccharide capsule is largely unclear for Streptococcus pneumoniae keratitis, an ocular inflammatory disease that develops as a result of bacterial infection of the cornea. In this study, capsule-deficient …
View article: Draft Genome Sequences of Viridans Streptococci Causing Bacterial Endophthalmitis in Humans
Draft Genome Sequences of Viridans Streptococci Causing Bacterial Endophthalmitis in Humans Open
The viridans streptococci are a group of bacteria that are commensals of the oral cavity and pharynx. These species tend to cause severe cases of bacterial endophthalmitis with poor prognoses but remain largely uncharacterized in this cont…
View article: Pathogenicity and virulence of<i>Streptococcus pneumoniae</i>: Cutting to the chase on proteases
Pathogenicity and virulence of<i>Streptococcus pneumoniae</i>: Cutting to the chase on proteases Open
Bacterial proteases and peptidases are integral to cell physiology and stability, and their necessity in Streptococcus pneumoniae is no exception. Protein cleavage and processing mechanisms within the bacterial cell serve to ensure that th…
View article: A Transcriptional Activator of Ascorbic Acid Transport in Streptococcus pneumoniae Is Required for Optimal Growth in Endophthalmitis in a Strain-Dependent Manner
A Transcriptional Activator of Ascorbic Acid Transport in Streptococcus pneumoniae Is Required for Optimal Growth in Endophthalmitis in a Strain-Dependent Manner Open
Streptococcus pneumoniae is among the top causes of bacterial endophthalmitis, an infectious disease of the intraocular fluids. The mechanisms by which S. pneumoniae grows and thrives in the intraocular cavity are not well understood. We u…
View article: Staphylococcus aureus Superantigen-Like Protein SSL1: A Toxic Protease
Staphylococcus aureus Superantigen-Like Protein SSL1: A Toxic Protease Open
Staphylococcus aureus is a major cause of corneal infections that can cause reduced vision, even blindness. Secreted toxins cause tissue damage and inflammation resulting in scars that lead to vision loss. Identifying tissue damaging prote…
View article: Antibiotic susceptibility, cytotoxicity, and protease activity of viridans group streptococci causing endophthalmitis
Antibiotic susceptibility, cytotoxicity, and protease activity of viridans group streptococci causing endophthalmitis Open
The viridans group streptococci comprise multiple species and have gained more recognition in recent years as common etiologic agents of bacterial endophthalmitis. The purpose of this study was to identify the species of human endophthalmi…
Mechanism of<i>Pseudomonas aeruginosa</i>Small Protease (PASP), a Corneal Virulence Factor Open
PASP is a secreted serine protease that can cleave proteins at arginine or lysine residues and PASP activity requires dimer or larger aggregates to create a functional active site. Most importantly, proteolytic PASP molecules demonstrated …
View article: The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases
The Role of Pneumococcal Virulence Factors in Ocular Infectious Diseases Open
Streptococcus pneumoniae is a gram-positive, facultatively anaerobic pathogen that can cause severe infections such as pneumonia, meningitis, septicemia, and middle ear infections. It is also one of the top pathogens contributing to bacter…
View article: Differential Bacterial Gene Expression during Experimental Pneumococcal Endophthalmitis
Differential Bacterial Gene Expression during Experimental Pneumococcal Endophthalmitis Open
Streptococcus pneumoniae (pneumococcus) is a potential cause of bacterial endophthalmitis in humans that can result in ocular morbidity. We sought to identify pneumococcal genes that are differentially expressed during growth in the vitreo…