Eleanor Walker
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View article: Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses
Cross-neutralizing and potent human monoclonal antibodies against historical and emerging H5Nx influenza viruses Open
Highly pathogenic avian influenza H5Nx viruses are an emerging threat for global health, especially clade 2.3.4.4b H5N1 virus which causes panzootic infections. Here we describe the isolation and characterization of broadly cross-neutraliz…
View article: Development of a patient-reported outcome measure for gastrointestinal recovery after surgery (PRO-diGI)
Development of a patient-reported outcome measure for gastrointestinal recovery after surgery (PRO-diGI) Open
Background After major abdominal surgery, patients may experience significant gastrointestinal dysfunction, including postoperative ileus. Many clinical tools are used to measure this dysfunction, but there is no patient-reported outcome m…
View article: Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies
Structural Convergence and Water-Mediated Substrate Mimicry Enable Broad Neuraminidase Inhibition by Human Antibodies Open
Influenza has been responsible for multiple global pandemics and seasonal epidemics and claimed millions of lives. The imminent threat of a panzootic outbreak of avian influenza H5N1 virus underscores the urgent need for pandemic preparedn…
View article: Cancer clinical trial participation: a qualitative study of Black/African American communities’ and patient/survivors’ recommendations
Cancer clinical trial participation: a qualitative study of Black/African American communities’ and patient/survivors’ recommendations Open
Background Black/African Americans experience disproportionate cancer burden and mortality rates. Racial and ethnic variation in cancer burden reflects systemic and health-care inequities, cancer risk factors, and heredity and genomic dive…
View article: BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer
BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer Open
Background Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective targets, it is crucial to identify novel mo…
View article: BUB1 Inhibition Sensitizes TNBC Cell Lines to Chemotherapy and Radiotherapy
BUB1 Inhibition Sensitizes TNBC Cell Lines to Chemotherapy and Radiotherapy Open
BUB1 is overexpressed in most human solid cancers, including breast cancer. Higher BUB1 levels are associated with a poor prognosis, especially in patients with triple-negative breast cancer (TNBC). Women with TNBC often develop resistance…
View article: BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer
BUB1 regulates non-homologous end joining pathway to mediate radioresistance in triple-negative breast cancer Open
Background Triple-negative breast cancer (TNBC) is a highly aggressive form of breast cancer subtype often treated with radiotherapy (RT). Due to its intrinsic heterogeneity and lack of effective targets, it is crucial to identify novel mo…
View article: BUB1 Inhibition Sensitizes TNBC Cell Lines to Chemotherapy and Radiotherapy
BUB1 Inhibition Sensitizes TNBC Cell Lines to Chemotherapy and Radiotherapy Open
BUB1 is overexpressed in most human solid cancers including breast cancer. Higher BUB1 levels are associated with poor prognosis especially in patients with triple-negative breast cancer (TNBC). Women with TNBC often develop resistance to …
View article: Identifying Factors Associated With Disparities in Access to Integrative Oncology Program
Identifying Factors Associated With Disparities in Access to Integrative Oncology Program Open
Patients' ethno-national origin and immigration status (primary language, Arabic and Russian), male gender and older age were associated with lower rates of referral to and attendance of the IP consultation, with reduced adherence to weekl…
View article: Hyperspectral shadow removal with Iterative Logistic Regression and latent Parametric Linear Combination of Gaussians
Hyperspectral shadow removal with Iterative Logistic Regression and latent Parametric Linear Combination of Gaussians Open
Shadow detection and removal is a challenging problem in the analysis of hyperspectral images. Yet, this step is crucial for analyzing data for remote sensing applications like methane detection. In this work, we develop a shadow detection…
View article: OGBN O02 Ergonomics in laparoscopic cholecystectomy. Do we need to change our practice to look after ourselves?
OGBN O02 Ergonomics in laparoscopic cholecystectomy. Do we need to change our practice to look after ourselves? Open
Background Up to 80% of surgeons report musculoskeletal problems which significantly affect their personal and professional lives. The cost of back pain alone in the NHS costs £400 million per year (for all staff), and surveyed surgeons re…
View article: Litter quality outweighs climate as a driver of decomposition across the tundra biome
Litter quality outweighs climate as a driver of decomposition across the tundra biome Open
Considerable uncertainty exists regarding the strength, direction and relative importance of the drivers of decomposition in the tundra biome, partly due to a lack of coordinated decomposition field studies in this remote environment. Here…
View article: Experimental evidence of litter quality and soil moisture rather than temperature as the key driver of litter decomposition along a high-latitude elevational gradient
Experimental evidence of litter quality and soil moisture rather than temperature as the key driver of litter decomposition along a high-latitude elevational gradient Open
High-latitude soils contain up to 60% of the world’s carbon stocks, but are vulnerable to carbon loss as climate change alters temperature and precipitation, litter quality, and soil biota. Tundra soils are thought to be particularly sensi…
View article: Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline
Integrative Medicine for Pain Management in Oncology: Society for Integrative Oncology–ASCO Guideline Open
PURPOSE The aim of this joint guideline is to provide evidence-based recommendations to practicing physicians and other health care providers on integrative approaches to managing pain in patients with cancer. METHODS The Society for Integ…
View article: Future of Surgery: Technology Enhanced Surgical Training: Report of the FOS:TEST Commission
Future of Surgery: Technology Enhanced Surgical Training: Report of the FOS:TEST Commission Open
Over the past 50 years the capability of technology to improve surgical care has been realised and while surgical trainees and trainers strive to deliver care and train; the technological ‘solutions’ market continues to expand. However, th…
View article: Mediators of Racial Disparities in Heart Dose Among Whole Breast Radiotherapy Patients
Mediators of Racial Disparities in Heart Dose Among Whole Breast Radiotherapy Patients Open
Background Racial disparities in survival of patients with cancer motivate research to quantify treatment disparities and evaluate multilevel determinants. Previous research has not evaluated cardiac radiation dose in large cohorts of brea…
View article: Testing the Short-Term Effectiveness of Various Deterrents for Reducing Crop Foraging by Primates
Testing the Short-Term Effectiveness of Various Deterrents for Reducing Crop Foraging by Primates Open
Crop foraging by wildlife is a major driver of negative interactions between farmers and wildlife, and yet there are few published examples of effective solutions to deter wildlife from crops. Here we investigate the effectiveness of six d…
View article: Identifying Patients Whose Symptoms Are Underrecognized During Treatment With Breast Radiotherapy
Identifying Patients Whose Symptoms Are Underrecognized During Treatment With Breast Radiotherapy Open
The results of this cohort study suggest that PRO collection may be essential for trials because relying on the CTCAE to detect adverse events may miss important symptoms. Moreover, since physicians in this study systematically missed subs…
View article: Cancer Clinical Trials Recruitment and Retention Strategies for Black and African Americans with Breast, Lung, Prostate, Colorectal, or Multiple Myeloma Cancer: A Scoping Review Protocol
Cancer Clinical Trials Recruitment and Retention Strategies for Black and African Americans with Breast, Lung, Prostate, Colorectal, or Multiple Myeloma Cancer: A Scoping Review Protocol Open
This project is funded by Genentech, Inc, 2020 Health Equity Innovations Fund