Mary Gonzalez Melo
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View article: Extracellular vesicle signature is associated with cardio-metabolic improvement after bariatric surgery
Extracellular vesicle signature is associated with cardio-metabolic improvement after bariatric surgery Open
Aims Bariatric surgery (BS) reduces obesity-associated systemic inflammation leading to multiple cardiovascular (CV) and metabolic benefits. Here, we tested whether measuring vaso-inflammatory cytokines, gut hormones, and circulating extra…
View article: Dyslipidemic SPTLC3 Integrates Bile Acid-FXR Signaling with Sphingolipid Remodeling in MASLD
Dyslipidemic SPTLC3 Integrates Bile Acid-FXR Signaling with Sphingolipid Remodeling in MASLD Open
Molecular mechanisms driving metabolic disease pathogenesis remain poorly understood. Genetic and functional studies implicate SPTLC3 with dyslipidemia. SPTLC3 synthesizes atypical long-chain bases (LCB) precursors for sphingolipid product…
View article: Primary Graft Dysfunction and Baseline Lung Allograft Dysfunction: Risk Factors and Associations With Patient Outcomes
Primary Graft Dysfunction and Baseline Lung Allograft Dysfunction: Risk Factors and Associations With Patient Outcomes Open
Background Primary graft dysfunction (PGD) is the leading cause of early postoperative mortality and morbidity after lung transplant (LTx), but limited evidence exists on the association between PGD and baseline lung allograft dysfunction …
View article: Repeated Anatomical Pulmonary Resection for Second Primary Non-Small Cell Lung Cancer: Safety, Feasibility and Short-Term Outcomes
Repeated Anatomical Pulmonary Resection for Second Primary Non-Small Cell Lung Cancer: Safety, Feasibility and Short-Term Outcomes Open
Background Advances in non-small cell lung cancer (NSCLC) management have extended survival rates, contributing to a higher incidence of second primary NSCLC (2-20%). Repeated anatomical pulmonary resection in these cases poses significant…
View article: Modeling human atherosclerotic lesions in the test tube: Are we there yet?
Modeling human atherosclerotic lesions in the test tube: Are we there yet? Open
Atherosclerotic cardiovascular diseases remain a leading cause of morbidity and mortality worldwide. Atherogenesis is a slow and life-long process characterized by the accumulation of lipoproteins and immune cells within the arterial wall.…
View article: Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons
Dual topologies of myotomal collagen XV and Tenascin C act in concert to guide and shape developing motor axons Open
During development, motor axons are guided toward muscle target by various extrinsic cues including extracellular matrix (ECM) proteins whose identities and cellular source remain poorly characterized. Here, using single-cell RNAseq of sor…
View article: Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons
Dual-topology of collagen XV and tenascin C acts in concert to guide and shape developing motor axons Open
During development, motor axons are guided towards their muscle target by various extrinsic cues including extracellular matrix (ECM) proteins those identities remain poorly documented. Using single-cell RNA-sequencing of differentiating s…
View article: Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis
Medical and Personal Characteristics Can Predict the Risk of Lung Metastasis Open
View article: Cytosolic DNA Sensors as a New Pharmacological Target in EVLP
Cytosolic DNA Sensors as a New Pharmacological Target in EVLP Open
View article: A knock-in rat model unravels acute and chronic renal toxicity in glutaric aciduria type I
A knock-in rat model unravels acute and chronic renal toxicity in glutaric aciduria type I Open
Glutaric aciduria type I (GA-I, OMIM # 231670) is an autosomal recessive inborn error of metabolism caused by deficiency of the mitochondrial enzyme glutaryl-CoA dehydrogenase (GCDH). The principal clinical manifestation in GA-I patients i…
View article: The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery
The first knock-in rat model for glutaric aciduria type I allows further insights into pathophysiology in brain and periphery Open
Glutaric aciduria type I (GA-I, OMIM # 231670) is an inborn error of metabolism caused by a deficiency of glutaryl-CoA dehydrogenase (GCDH). Patients develop acute encephalopathic crises (AEC) with striatal injury most often triggered by c…
View article: The use of <sup>68</sup>Ga-EDTA PET allows detecting progressive decline of renal function in rats.
The use of <sup>68</sup>Ga-EDTA PET allows detecting progressive decline of renal function in rats. Open
68Ga-EDTA turned out to be a very promising PET/CT tracer for the evaluation of split renal function. This method allowed detection of progressive renal impairment in a knock-in rat model. Additional validation in a human cohort…