Mary K. Hayden
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View article: Citywide indoor air sampling mirrors wastewater and clinical case surveillance of respiratory viruses
Citywide indoor air sampling mirrors wastewater and clinical case surveillance of respiratory viruses Open
Wastewater surveillance of respiratory pathogens can provide timely estimates of viral activity and disease trends in a population. Indoor air surveillance could be used similarly with some advantages but remains largely unvalidated at the…
View article: Genomic analysis of Candida auris transmission within an urban region
Genomic analysis of Candida auris transmission within an urban region Open
Candida auris emerged in Chicago, IL, USA, in 2016 and has since become endemic. We used whole-genome sequencing (WGS) of 494 isolates, epidemiologic metadata and patient transfer data to describe the transmission of C. auris among Chicago…
View article: Microbiota Transplantation Among Patients Receiving Long-Term Care
Microbiota Transplantation Among Patients Receiving Long-Term Care Open
Importance Intestinal multidrug-resistant organism (MDRO) colonization is highly prevalent in long-term acute care hospital (LTACH) patients and is associated with MDRO infection and transmission. However, there are no therapies approved b…
View article: Whither immunity? The search for effective, durable immunity to coronavirus disease 2019 (COVID-19)
Whither immunity? The search for effective, durable immunity to coronavirus disease 2019 (COVID-19) Open
One of the most important and challenging questions facing medicine today concerns the extent to which immunity develops and persists following coronavirus disease 2019 (COVID-19), that is, infection with severe acute respiratory coronavir…
View article: Preparing nursing homes for a second wave of coronavirus disease 2019 (COVID-19)
Preparing nursing homes for a second wave of coronavirus disease 2019 (COVID-19) Open
Among deaths related to coronavirus disease 2019 (COVID-19) in the United States, 40% have been linked to nursing homes. Nursing homes commonly have limited access to infection prevention and control (IPC) experts, and they are set up so t…
View article: Organizational strategies for managing COVID-19 survivors who return for care
Organizational strategies for managing COVID-19 survivors who return for care Open
As the coronavirus disease 2019 (COVID-19) pandemic has evolved, survivors are now returning for care at hospitals and ambulatory sites, creating confusion and uncertainty for the frontline staff regarding proper management of these patien…
View article: Transmission patterns of<i>Candida auris</i>among regional healthcare facilities revealed by genomic epidemiology and patient transfer data
Transmission patterns of<i>Candida auris</i>among regional healthcare facilities revealed by genomic epidemiology and patient transfer data Open
Candida auris emerged in Chicago, IL, USA in 2016 and has since become endemic. We used whole genome sequencing (WGS) of 494 isolates, epidemiologic metadata, and patient transfer data to describe the transmission of C. auris among Chicago…
View article: Local, state and federal face mask mandates during the COVID-19 pandemic
Local, state and federal face mask mandates during the COVID-19 pandemic Open
It has been well established that severe acute respiratory coronavirus virus 2 (SARS-CoV-2), the virus that causes coronavirus disease 2019 (COVID-19), is spread primarily through respiratory droplets. In healthcare facilities with adheren…
View article: Regression-based modeling of pairwise genomic linkage data identifies risk factors for healthcare-associated infection transmission: Application to carbapenem-resistant<i>Klebsiella pneumoniae</i>transmission in a long-term care facility
Regression-based modeling of pairwise genomic linkage data identifies risk factors for healthcare-associated infection transmission: Application to carbapenem-resistant<i>Klebsiella pneumoniae</i>transmission in a long-term care facility Open
Background Pathogen whole genome sequencing (WGS) has significant potential for improving healthcare-associated infection (HAI) outcomes. However, methods for integrating WGS with epidemiologic data to quantify risks for pathogen spread re…
View article: Hospital air sampling enables surveillance of respiratory virus infections and genomes
Hospital air sampling enables surveillance of respiratory virus infections and genomes Open
There is an urgent need for early detection and comprehensive surveillance of respiratory pathogens. Environmental surveillance may be key to timely responses for newly emerging pathogens and infections that are unreported or underreported…
View article: Hospital air sampling enables surveillance of respiratory virus infections and genomes
Hospital air sampling enables surveillance of respiratory virus infections and genomes Open
There is an urgent need for early detection and comprehensive surveillance of respiratory pathogens. Environmental surveillance may be key to timely responses for newly emerging pathogens and infections that are unreported or underreported…
View article: Sewer monitoring for antimicrobial resistance genes and organisms at healthcare facilities
Sewer monitoring for antimicrobial resistance genes and organisms at healthcare facilities Open
Surveillance of wastewater from healthcare facilities has the potential to identify the emergence of multidrug-resistant organisms (MDROs) of public health importance. Specifically, wastewater surveillance can provide sentinel surveillance…
View article: <i>Candida auris</i> Outbreak and Epidemiologic Response in Burn Intensive Care Unit, Illinois, USA, 2021–2023
<i>Candida auris</i> Outbreak and Epidemiologic Response in Burn Intensive Care Unit, Illinois, USA, 2021–2023 Open
Candida auris is an emerging fungal pathogen associated with outbreaks in healthcare settings. We report a multiyear outbreak of C. auris in a burn intensive care unit in Illinois, USA, during 2021-2023. We identified 28 C. auris cases in …
View article: P-1265. Risk Factors for Contamination of Healthcare Personnel Gloves and Gown with <i>Candida auris</i> (<i>C. auris</i>)
P-1265. Risk Factors for Contamination of Healthcare Personnel Gloves and Gown with <i>Candida auris</i> (<i>C. auris</i>) Open
Background C. auris is a rapidly emerging pathogen with the ability to spread quickly in healthcare settings. This study aims to describe patient, healthcare personnel (HCP), and environmental risk factors for hospital transmission of C. a…
View article: P-2176. Validation of Air Sampling and Real-Time Quantitative Polymerase Chain Reaction for Measles Virus Surveillance: A Single-Center, Preliminary Assessment
P-2176. Validation of Air Sampling and Real-Time Quantitative Polymerase Chain Reaction for Measles Virus Surveillance: A Single-Center, Preliminary Assessment Open
Background During the early months of Chicago’s 2024 measles outbreak, many patients were admitted to local hospitals due to a lack of isolation housing in congregate settings. While the infection control potential of air sampling for vira…
View article: 444. SHEA FEATURED ORAL ABSTRACT: INSPIRE Trial: A 92-Hospital Cluster Randomized Trial of INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection versus Routine Antibiotic Selection Practices for Patients with Abdominal Infections
444. SHEA FEATURED ORAL ABSTRACT: INSPIRE Trial: A 92-Hospital Cluster Randomized Trial of INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection versus Routine Antibiotic Selection Practices for Patients with Abdominal Infections Open
Background Up to 40% of hospitalized patients receive empiric extended-spectrum (ES) antibiotics despite low risk of multidrug-resistant organism (MDRO) infection, increasing the risk for adverse effects and future resistance. We evaluated…
View article: 179. INSPIRE Trial: A 92-Hospital Cluster Randomized Trial of INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection versus Routine Antibiotic Selection Practices for Patients with Skin and Soft Tissue Infections
179. INSPIRE Trial: A 92-Hospital Cluster Randomized Trial of INtelligent Stewardship Prompts to Improve Real-time Empiric Antibiotic Selection versus Routine Antibiotic Selection Practices for Patients with Skin and Soft Tissue Infections Open
Background Up to 40% of hospitalized patients receive extended-spectrum (ES) antibiotics despite low risk of multidrug-resistant organism (MDRO) infection, increasing the risk for adverse effects and future resistance. We evaluated whether…
View article: Pathogen genomics in healthcare: overcoming barriers to proactive surveillance
Pathogen genomics in healthcare: overcoming barriers to proactive surveillance Open
Pathogen genomic surveillance in healthcare has the potential to enhance patient safety by detecting outbreaks earlier, thereby reducing morbidity and mortality. Despite benefits, there are barriers to adoption, including cost, expertise, …
View article: Hospital environments harbor chlorhexidine tolerant bacteria potentially linked to chlorhexidine persistence in the environment
Hospital environments harbor chlorhexidine tolerant bacteria potentially linked to chlorhexidine persistence in the environment Open
A One Health approach is essential in combating antibiotic and antimicrobial resistance. Chlorhexidine (di)gluconate (CHG), a widely used antiseptic in medical intensive care units (MICU), has recently come under scrutiny. However, studies…
View article: 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Diagnostic Imaging of Suspected Acute Appendicitis in Adults, Children, and Pregnant People
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Diagnostic Imaging of Suspected Acute Appendicitis in Adults, Children, and Pregnant People Open
This paper is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infe…
View article: 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Diagnostic Imaging of Suspected Acute Diverticulitis in Adults and Pregnant People
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Diagnostic Imaging of Suspected Acute Diverticulitis in Adults and Pregnant People Open
This paper is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infe…
View article: 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Utility of Intra-abdominal Fluid Cultures in Adults, Children, and Pregnant People
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Utility of Intra-abdominal Fluid Cultures in Adults, Children, and Pregnant People Open
This paper is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infe…
View article: 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Utility of Blood Cultures in Adults, Children, and Pregnant People
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Utility of Blood Cultures in Adults, Children, and Pregnant People Open
This article is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the In…
View article: 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Risk Assessment, Diagnostic Imaging, and Microbiological Evaluation in Adults, Children, and Pregnant People
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intra-abdominal Infections: Risk Assessment, Diagnostic Imaging, and Microbiological Evaluation in Adults, Children, and Pregnant People Open
As the first part of an update to the clinical practice guideline on the diagnosis and management of complicated intra-abdominal infections in adults, children, and pregnant people, developed by the Infectious Diseases Society of America, …
View article: 2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intraabdominal Infections: Diagnostic Imaging of Suspected Acute Cholecystitis and Acute Cholangitis in Adults, Children, and Pregnant People
2024 Clinical Practice Guideline Update by the Infectious Diseases Society of America on Complicated Intraabdominal Infections: Diagnostic Imaging of Suspected Acute Cholecystitis and Acute Cholangitis in Adults, Children, and Pregnant People Open
This article is part of a clinical practice guideline update on the risk assessment, diagnostic imaging, and microbiological evaluation of complicated intraabdominal infections in adults, children, and pregnant people, developed by the Inf…
View article: Application of a Model Using Prior Healthcare Information to Predict Multidrug-Resistant Organism (MDRO) Carriage
Application of a Model Using Prior Healthcare Information to Predict Multidrug-Resistant Organism (MDRO) Carriage Open
Background: Early identification of patients colonized with MDROs can help healthcare facilities improve infection control and treatment. We evaluated whether a model previously validated to predict carbapenem-resistant Enterobacterales (C…
View article: Stewardship Prompts to Improve Antibiotic Selection for Pneumonia
Stewardship Prompts to Improve Antibiotic Selection for Pneumonia Open
Importance Pneumonia is the most common infection requiring hospitalization and is a major reason for overuse of extended-spectrum antibiotics. Despite low risk of multidrug-resistant organism (MDRO) infection, clinical uncertainty often d…
View article: Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection
Stewardship Prompts to Improve Antibiotic Selection for Urinary Tract Infection Open
Importance Urinary tract infection (UTI) is the second most common infection leading to hospitalization and is often associated with gram-negative multidrug-resistant organisms (MDROs). Clinicians overuse extended-spectrum antibiotics alth…
View article: Reducing Hospitalizations and Multidrug-Resistant Organisms via Regional Decolonization in Hospitals and Nursing Homes
Reducing Hospitalizations and Multidrug-Resistant Organisms via Regional Decolonization in Hospitals and Nursing Homes Open
Importance Infections due to multidrug-resistant organisms (MDROs) are associated with increased morbidity, mortality, length of hospitalization, and health care costs. Regional interventions may be advantageous in mitigating MDROs and ass…