Mary Horgan
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View article: Process Evaluation of a Rapid Evidence Support System Assessment of Ireland’s Department of Health – A Protocol
Process Evaluation of a Rapid Evidence Support System Assessment of Ireland’s Department of Health – A Protocol Open
Background The Rapid Evidence Support System Assessment (RESSA) was developed by the Global Evidence Commission to evaluate evidence support systems that inform policy decisions. These systems are designed to contextualise existing evidenc…
View article: Antibody Responses are Sustained 2 Years Post-Mpox Infection but not Following Modified Vaccinia Ankara–Bavarian Nordic Vaccination
Antibody Responses are Sustained 2 Years Post-Mpox Infection but not Following Modified Vaccinia Ankara–Bavarian Nordic Vaccination Open
Background Clade IIb mpox cases have declined globally, likely due to behavioral changes alongside vaccine- and infection-induced immunity. However, infections in vaccinated individuals raise concerns about immunity durability. We compared…
View article: Salivary antibodies mirror systemic humoral immunity to SARS CoV-2 and reveal sex-specific differences in salivary anti-spike IgA and IgG levels
Salivary antibodies mirror systemic humoral immunity to SARS CoV-2 and reveal sex-specific differences in salivary anti-spike IgA and IgG levels Open
Durable antibody responses are essential for long-term protection against SARS-CoV-2. We assessed the utility of point-of-care lateral flow tests (LFTs) versus ELISA in monitoring systemic and mucosal immunity and explored saliva as a surr…
View article: A Rapid Evidence Support System Assessment (RESSA) of health policymaking in Ireland – A Protocol
A Rapid Evidence Support System Assessment (RESSA) of health policymaking in Ireland – A Protocol Open
Background Evidence-informed policymaking promotes the use of the best available evidence in a systematic and transparent manner to guide policy decisions. It aims to ensure that policies are grounded in credible and relevant evidence whil…
View article: Specific thresholds of circulating antibody titers predict against infection and reduced disease severity in SARS-CoV-2 close contacts
Specific thresholds of circulating antibody titers predict against infection and reduced disease severity in SARS-CoV-2 close contacts Open
Higher circulating SARS-CoV-2 IgG titers correlate with SARS-CoV-2 ex vivo viral neutralization, but how well this translates to clinical protection in the real-world setting is unclear. In a prospective cohort study, we enrolled 44 SARS-C…
View article: Associations between type III interferons, obesity and clinical severity of COVID-19
Associations between type III interferons, obesity and clinical severity of COVID-19 Open
Introduction Severe COVID-19 is characterized by hyperimmune host responses contributing to airway damage and acute respiratory distress syndrome. Type III interferons (IFN), including IFN lambda 4 (IFNλ4), expressed in individuals harbori…
View article: Synthesizing Public Health Preparedness Mechanisms for High‐Impact Infectious Disease Threats: A Jurisdictional Scan
Synthesizing Public Health Preparedness Mechanisms for High‐Impact Infectious Disease Threats: A Jurisdictional Scan Open
Aim High‐impact infectious diseases pose major global health challenges, underscoring the urgent need for robust public health preparedness. Despite efforts to improve global health security, recent pandemics have revealed significant weak…
View article: Development and validation of a quantitative Orthopoxvirus immunoassay to evaluate and differentiate serological responses to Mpox infection and vaccination
Development and validation of a quantitative Orthopoxvirus immunoassay to evaluate and differentiate serological responses to Mpox infection and vaccination Open
Health Research Board (MONKEYVAX-2022-1), University College Dublin School of Medicine.
View article: Process Evaluation of a Rapid Evidence Support System Assessment of Ireland’s Department of Health – A Protocol
Process Evaluation of a Rapid Evidence Support System Assessment of Ireland’s Department of Health – A Protocol Open
Background The Rapid Evidence Support System Assessment (RESSA) was developed by the Global Evidence Commission to evaluate evidence support systems that inform policy decisions. These systems are designed to contextualize existing evidenc…
View article: Patterns and drivers of excess mortality during the COVID-19 pandemic in 13 Western European countries
Patterns and drivers of excess mortality during the COVID-19 pandemic in 13 Western European countries Open
These results suggest the benefit of early implementation of NPIs and swift rollout of vaccines to the most vulnerable. Further analyses are required at a more granular level to better understand how these factors impacted excess mortality…
View article: Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection
Robust and persistent B-cell responses following SARS-CoV-2 vaccine determine protection from SARS-CoV-2 infection Open
Introduction A clear immune correlate of protection from severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has not been defined. We explored antibody, B-cell, and T-cell responses to the third-dose vaccine and relation…
View article: Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis
Early inflammatory profiles predict maximal disease severity in COVID-19: An unsupervised cluster analysis Open
View article: Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus
Distinct Inflammatory Phenotypes Are Associated With Subclinical and Clinical Cardiovascular Disease in People With Human Immunodeficiency Virus Open
Despite inflammation being implicated in cardiovascular disease (CVD) in people with human immunodeficiency virus (PWH), considerable heterogeneity within populations of PWH exists. Stratifying CVD risk based on inflammatory phenotype coul…
View article: Robust and Persistent B Cell Responses Following Third-Dose SARS-CoV-2 Vaccine Determine Protection from SARS-CoV-2 Infection
Robust and Persistent B Cell Responses Following Third-Dose SARS-CoV-2 Vaccine Determine Protection from SARS-CoV-2 Infection Open
View article: Factors influencing medical students’ decision to pursue a career in obstetrics and gynaecology
Factors influencing medical students’ decision to pursue a career in obstetrics and gynaecology Open
Introduction The career intentions of medical students can exert influence on service provision and medical staffing in the health services. It is vital for a specialty’s development and sustainability that it has a constant stream of trai…
View article: Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening
Development of a novel medium throughput flow-cytometry based micro-neutralisation test for SARS-CoV-2 with applications in clinical vaccine trials and antibody screening Open
Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated post-infection/post-vaccination. Here we describe a novel medium-throughput flow cytometry-based…
View article: 1346. Genetic Variation at the Interferon λ Locus and Association with Clinical Outcome and Severity of COVID-19
1346. Genetic Variation at the Interferon λ Locus and Association with Clinical Outcome and Severity of COVID-19 Open
Background People with obesity are at increased risk of severe COVID-19, with host inflammation a key contributor. Interferon (IFN) lambda 4 (IFNλ4) is a type III IFN expressed in individuals with the rs368234815-ΔG single nucleotide polym…
View article: 2356. Close correlation of RBD with Live Viral Neutralising Capacity Across Variants and Time Supports Use of RBD Thresholds to Predict Protective Host Immunity
2356. Close correlation of RBD with Live Viral Neutralising Capacity Across Variants and Time Supports Use of RBD Thresholds to Predict Protective Host Immunity Open
Background Although SARS-CoV-2 neutralising antibodies protect against severe COVID-19, whether circulating IgG titres reflect underlying host capacity to neutralise wild type (WT) and variants of concern (VOC) and what IgG threshold refle…
View article: Impact of vaccination and variants of concern on long COVID clinical phenotypes
Impact of vaccination and variants of concern on long COVID clinical phenotypes Open
Background Defining patterns of symptoms in long COVID is necessary to advance therapies for this heterogeneous condition. Here we aimed to describe clusters of symptoms in individuals with long COVID and explore the impact of the emergenc…
View article: Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time
Distinct receptor binding domain IgG thresholds predict protective host immunity across SARS-CoV-2 variants and time Open
View article: Scientific advisory councils in the COVID-19 response
Scientific advisory councils in the COVID-19 response Open
View article: Robust cross-cohort gut microbiome associations with COVID-19 severity
Robust cross-cohort gut microbiome associations with COVID-19 severity Open
Although many recent studies have examined associations between the gut microbiome and COVID-19 disease severity in individual patient cohorts, questions remain on the robustness across international cohorts of the biomarkers they reported…
View article: Development of a Novel Medium Throughput Flow-Cytometry Based Micro-Neutralisation Test for SARS-CoV-2 with Applications in Clinical Vaccine Trials and Antibody Screening
Development of a Novel Medium Throughput Flow-Cytometry Based Micro-Neutralisation Test for SARS-CoV-2 with Applications in Clinical Vaccine Trials and Antibody Screening Open
Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated post-infection/post-vaccination. Here we describe a novel medium-throughput flow cytometry-based…
View article: A qualitative review of challenges in recruitment and retention in obstetrics and gynecology in Ireland: The consultants’ solution based perspective
A qualitative review of challenges in recruitment and retention in obstetrics and gynecology in Ireland: The consultants’ solution based perspective Open
Aim Recruitment and retention remains a concern in obstetrics and gynecology, with consultants having a unique perspective on the daily challenges. We aimed to examine these and examine their solutions to future-proofing the workforce. Met…
View article: 1057. Development of a Flow Cytometry-Based Micro-Neutralisation Assay to Evaluate Humoral Immunity Against SARS-CoV-2 Variants of Concern in Vaccine Trials
1057. Development of a Flow Cytometry-Based Micro-Neutralisation Assay to Evaluate Humoral Immunity Against SARS-CoV-2 Variants of Concern in Vaccine Trials Open
Background Quantifying neutralising capacity of circulating SARS-COV-2 antibodies is critical in evaluating protective humoral immune responses generated post-infection/post-vaccination. Here we describe a novel medium-throughput flow cyto…
View article: 1959. Lower B-Cell Responses Rather Than Circulating Antibody Titres Are Associated With SARS-CoV-2 Infection Post Third Dose COVID-19 Vaccination
1959. Lower B-Cell Responses Rather Than Circulating Antibody Titres Are Associated With SARS-CoV-2 Infection Post Third Dose COVID-19 Vaccination Open
Background Which components of the immune response to SARS-CoV-2 vaccination best protect against subsequent infection remains unclear. We explored SARS-CoV-2 specific antibody and B-cell responses post 3rd dose vaccine and their relations…
View article: LB9 Process improvement for ambulatory upper limb soft tissue trauma surgery
LB9 Process improvement for ambulatory upper limb soft tissue trauma surgery Open
Background and Aims Regional anaesthesia (RA) is ideally suited to upper limb soft tissue trauma surgery (ULSTTS). Compared to general anaesthesia (GA), RA confers several benefits including: better analgesia; less postoperative nausea and…
View article: B141 Process improvement for ambulatory upper limb soft tissue trauma surgery
B141 Process improvement for ambulatory upper limb soft tissue trauma surgery Open
Background and Aims Regional anaesthesia (RA) is ideally suited to upper limb soft tissue trauma surgery (ULSTTS). Compared to general anaesthesia (GA), RA confers several benefits including: better analgesia; less postoperative nausea and…
View article: A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2
A high-risk gut microbiota configuration associates with fatal hyperinflammatory immune and metabolic responses to SARS-CoV-2 Open
Protection against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection and associated clinical sequelae requires well-coordinated metabolic and immune responses that limit viral spread and promote recovery of damaged sys…
View article: Impact of Long COVID on health and quality of life
Impact of Long COVID on health and quality of life Open
Background: The aim of this study was to measure the impact of post-acute sequelae of COVID-19 (PASC) on quality of life, mental health, ability to work and return to baseline health in an Irish cohort. Methods: We invited individuals with…