Mary Kay Harper
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View article: Isolation, Structure Elucidation and Biological Evaluation of Lomaiviticins F–H, Dimeric Benzofluorene Glycosides from Marine-Derived Micromonospora sp. Bacterium
Isolation, Structure Elucidation and Biological Evaluation of Lomaiviticins F–H, Dimeric Benzofluorene Glycosides from Marine-Derived Micromonospora sp. Bacterium Open
The discovery of new natural products remains a cornerstone of therapeutic innovation, and effective analytical tools for rapid dereplication can significantly accelerate this process. Using Isotopic Fine Structure (IFS) mass spectrometry,…
View article: Genome Mining and Metabolomics Unveil Pseudonochelin: A Siderophore Containing 5-Aminosalicylate from a Marine-Derived <i>Pseudonocardia</i> sp. Bacterium
Genome Mining and Metabolomics Unveil Pseudonochelin: A Siderophore Containing 5-Aminosalicylate from a Marine-Derived <i>Pseudonocardia</i> sp. Bacterium Open
Pseudonochelin (1), a siderophore from a marine-derived Pseudonocardia sp. bacterium, was discovered using genome mining and metabolomics technologies. A 5-aminosalicylic acid (5-ASA) unit, not previously found in siderophore…
View article: Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers
Topsentinol L Trisulfate, a Marine Natural Product That Targets Basal-like and Claudin-Low Breast Cancers Open
Patients diagnosed with basal-like breast cancer suffer from poor prognosis and limited treatment options. There is an urgent need to identify new targets that can benefit patients with basal-like and claudin-low (BL-CL) breast cancers. We…
View article: Development of a novel and rapid phenotype-based screening method to assess rice seedling growth
Development of a novel and rapid phenotype-based screening method to assess rice seedling growth Open
View article: Topsentinol L Trisulfate, a new Marine Natural Product, that Targets Basal-like and Claudin-low Breast Cancers
Topsentinol L Trisulfate, a new Marine Natural Product, that Targets Basal-like and Claudin-low Breast Cancers Open
Background Breast cancer is a heterogeneous disease. Genomic studies have revealed five different intrinsic subtypes - Luminal A, Luminal B, HER2-enriched, Claudin-low, and Basal-like. Patients diagnosed with Basal-like or Claudin-low brea…
View article: Myrmenaphthol A, Isolated from a Hawaiian Sponge of the Genus <i>Myrmekioderma</i>
Myrmenaphthol A, Isolated from a Hawaiian Sponge of the Genus <i>Myrmekioderma</i> Open
Four compounds (1-4) were isolated from a Hawaiian sponge of the genus Myrmekioderma. Myrmenaphthol A (1) incorporates two unusual elements into an oxidized steroidal core: a naphthyl AB-ring system and a hydrox…
View article: Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an <i>Actinomadura sp.</i>
Madurastatin D1 and D2, Oxazoline Containing Siderophores Isolated from an <i>Actinomadura sp.</i> Open
Two new siderophores, madurastatin D1 and D2, together with (-)-madurastatin C1, the enantiomer of a known compound, were isolated from marine-derived Actinomadura sp. The presence of an unusual 4-imidazolidinone ring in madurastati…
View article: Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans
Cytotoxic Sesquiterpenoid Quinones and Quinols, and an 11-Membered Heterocycle, Kauamide, from the Hawaiian Marine Sponge Dactylospongia elegans Open
Several known sesquiterpenoid quinones and quinols (1–9), and kauamide (10), a new polyketide-peptide containing an 11-membered heterocycle, were isolated from the extracts of the Hawaiian marine sponge Dactylospongia elegans. The planar s…
View article: Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
Correction: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research Open
Correction for ‘The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research’ by James B. McAlpine et al., Nat. Prod. Rep., 2018, DOI: 10.1039/c7np00064b.
View article: The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research
The value of universally available raw NMR data for transparency, reproducibility, and integrity in natural product research Open
With contributions from the global natural product (NP) research community, and continuing the Raw Data Initiative, this review collects a comprehensive demonstration of the immense scientific value of disseminating raw nuclear magnetic re…
View article: Chemical Metagenomics of an Anti-HIV Compound From Uncultivated Symbionts
Chemical Metagenomics of an Anti-HIV Compound From Uncultivated Symbionts Open
View article: Accessing chemical diversity from the uncultivated symbionts of small marine animals
Accessing chemical diversity from the uncultivated symbionts of small marine animals Open
View article: Brackish habitat dictates cultivable Actinobacterial diversity from marine sponges
Brackish habitat dictates cultivable Actinobacterial diversity from marine sponges Open
Bacterial communities associated with marine invertebrates such as sponges and ascidians have demonstrated potential as sources of bio-medically relevant small molecules. Metagenomic analysis has shown that many of these invertebrates harb…
View article: Marine natural products as inhibitors of cystathionine beta-synthase activity
Marine natural products as inhibitors of cystathionine beta-synthase activity Open