Brigid M. Lynch
YOU?
Author Swipe
View article: Faecal sample collection for gut microbiome research in a prospective cohort: a pilot study within the Australian Breakthrough Cancer Study
Faecal sample collection for gut microbiome research in a prospective cohort: a pilot study within the Australian Breakthrough Cancer Study Open
Large prospective analyses of human gut microbiome profiles are needed to elucidate the role of microbiome variation in the development of disease. We conducted a pilot study to assess the feasibility of home faecal sample collection withi…
View article: Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study
Physical activity and molecular subtypes of colorectal cancer: a pooled observational analysis and Mendelian randomization study Open
Background Physical activity is associated with lower colorectal cancer (CRC) risk, but its association with molecular subtypes defined by genetic and epigenetic alterations of the disease is unclear. Such information may enhance the under…
View article: Supplementary Table 4 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Supplementary Table 4 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Supplementary Table 4 shows the association between change in physical activity and the risk of obesity-related cancer remains consistent in sensitivity analyses excluding cancer cases in the first two-years of follow-up
View article: Data from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Data from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Background:Most studies investigating physical activity and cancer risk used a single-time measure of physical activity. The present analysis investigates whether changes in physical activity during midlife influence cancer risk.Methods:A …
View article: Supplementary Table 2 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Supplementary Table 2 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Supplementary Table 2 shows during the study follow-up, the most common cancers were prostate and breast cancer for males and females, respectively.
View article: Supplementary Table 3 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Supplementary Table 3 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Supplementary Table 3 shows the association between change in physical activity and the risk of cancer remains consistent in sensitivity analyses excluding cancer cases in the first two-years of follow-up
View article: Supplementary Table 1 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Supplementary Table 1 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Supplementary Table 1 shows that compared with participants who did not provide these data at follow-up, those included in this analysis were younger, more likely to be female, British, have higher Townsend deprivation index and higher att…
View article: Supplementary Table 7 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Supplementary Table 7 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Supplementary Table 7 shows that changes in overall physical activity were proportionally reflected across both walking and moderate-to-vigorous physical activity.
View article: Supplementary Table 5 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Supplementary Table 5 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Supplementary Table 5 shows the association between change in physical activity and the risk of non-obesity-related cancer remains consistent in sensitivity analyses excluding cancer cases in the first two-years of follow-up
View article: Supplementary Table 6 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study
Supplementary Table 6 from Changes in Physical Activity and Risk of Cancer, Findings from the UK Biobank Study Open
Supplementary Table 6 shows increasing physical activity from low to a higher level was associated with a lower risk of breast cancer, whilst no association was observed between change in physical activity and the risk of prostate cancer.
View article: Data Resource Profile: the Physical Activity Cohort Repository (PACe)
Data Resource Profile: the Physical Activity Cohort Repository (PACe) Open
Key Features * The Physical Activity Cohort Repository (PACe) project created a searchable online database of cohort studies that have prospectively collected data on physical activity and/or sedentary behaviour (self-report and/or device-…
View article: Cancer control measures have prevented 230,000 deaths in Australia since the mid-1980s
Cancer control measures have prevented 230,000 deaths in Australia since the mid-1980s Open
These estimates demonstrate the value of sustained cancer control investment, particularly in primary and secondary prevention.
View article: TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method
TGF-β-pathway-based polygenic risk score modifies the association between red meat intake and colorectal cancer risk: Application of a novel pathway-based PRS method Open
Background Red and/or processed meat are established colorectal cancer (CRC) risk factors. Genome-wide association studies (GWAS) have reported over 200 variants associated with CRC risk. We used functional annotation data to identify subs…
View article: Leisure-time physical activity after diagnosis and survival by cancer type: a pooled analysis
Leisure-time physical activity after diagnosis and survival by cancer type: a pooled analysis Open
Background Evidence for potential mortality benefits of leisure-time moderate-to-vigorous intensity physical activity (MVPA) for survivors of cancer types beyond breast and colorectal is limited. The aim of this study was to evaluate relat…
View article: Table S11 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S11 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between ABSI, colorectal cancer, and its molecular subtypes stratifying by early and later-onset.
View article: Table S1 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis
Table S1 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis Open
Minimum, median and maximum values of the quartiles of normalized biomarker concentrations
View article: Data from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Data from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Background:Waist circumference (WC) and its allometric counterpart, “a body shape index” (ABSI), are risk factors for colorectal cancer; however, it is uncertain whether associations with these body measurements are limited to specific mol…
View article: Figure S3 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis
Figure S3 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis Open
Figure S3 illustrates the assumed relationships between insulin, c-peptide, IGF-1, IGFBP-3, postmenopausal ER-positive breast cancer, and sociodemographic and lifestyle factors.
View article: Table S8 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S8 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between A Body Shape Index (ABSI), distal colon cancer, and its molecular subtypes.
View article: Supplementary figure S1 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary figure S1 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary figure S1: Total variation in the metabolomics data and its sources before and after the normalization procedure Panel A shows the overall variability and its sources before the normalization procedure and panel B shows the o…
View article: Data from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis
Data from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis Open
Background:Higher concentration of insulin-like growth factor-1 (IGF-1) increases postmenopausal breast cancer risk, but evidence for insulin and c-peptide is limited. Furthermore, not all studies have accounted for potential confounding b…
View article: Table S7 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S7 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between A Body Shape Index (ABSI), proximal colon cancer, and its molecular subtypes.
View article: Table S10 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis
Table S10 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis Open
Risk ratios and 95% confidence intervals of postmenopausal estrogen-receptor positive breast cancer per doubling biomarker concentration and by quartiles of biomarker concentration, excluding self-reported diabetics and users of oral hypog…
View article: Supplementary figure S3 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary figure S3 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary figure S3: The contribution to the metabolic signature of each identified metabolite This graph shows the loadings of the metabolites contributing to the metabolomic signature. Higher bars correspond to larger contribution of…
View article: Table S3 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis
Table S3 from Insulin and Insulin-like Growth Factor and Risk of Postmenopausal Estrogen Receptor–Positive Breast Cancer: A Case–Cohort Analysis Open
Geometric mean ratios for biomarkers in relation to body mass index
View article: Table S12 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies
Table S12 from Waist Circumference, a Body Shape Index, and Molecular Subtypes of Colorectal Cancer: A Pooled Analysis of Four Cohort Studies Open
Association between waist circumference, colorectal cancer, and its molecular subtypes after conducting multiple imputation.
View article: Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary table S6: Associations of physical activity with the metabolites analysed in the EPIC study without BMI adjustment.
View article: Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship
Supplementary table S6 from Identifying Metabolomic Mediators of the Physical Activity and Colorectal Cancer Relationship Open
Supplementary table S6: Associations of physical activity with the metabolites analysed in the EPIC study without BMI adjustment.