Mary F. Lyon
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View article: Do LINEs Have a Role in X‐Chromosome Inactivation?
Do LINEs Have a Role in X‐Chromosome Inactivation? Open
There is longstanding evidence that X‐chromosome inactivation (XCI) travels less successfully in autosomal than in X‐chromosomal chromatin. The interspersed repeat elements LINE1s (L1s) have been suggested as candidates for “boosters” whic…
View article: Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification
Activating calcium-sensing receptor mutation in the mouse is associated with cataracts and ectopic calcification Open
The extracellular calcium-sensing receptor (CaSR) plays a pivotal role in the regulation of extracellular calcium such that abnormalities, which result in a loss or gain of function, lead to hypercalcemia or hypocalcemia, respectively, in …
View article: <i>Vertebrate Sex Chromosomes</i>. Edited by N. T<scp>AKAGI</scp>. S. Karger AG. 2003. 352 pages. ISBN 3 8055 7637 4. Price $138.25 (hardback).
<i>Vertebrate Sex Chromosomes</i>. Edited by N. T<span>AKAGI</span>. S. Karger AG. 2003. 352 pages. ISBN 3 8055 7637 4. Price $138.25 (hardback). Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: A Personal History of the Mouse Genome
A Personal History of the Mouse Genome Open
The chapter describes some personal reminiscences of various stages in the growth of knowledge of the mouse genome in the past 50 years. Initially mapping was done by crossing new mutants with linkage testing stocks, a slow and laborious m…
View article: A Temperature-sensitive Mutation of Crygs in the Murine Opj Cataract
A Temperature-sensitive Mutation of Crygs in the Murine Opj Cataract Open
In Opj, an inherited cataract in mice, opacity is associated with a mutation in Crygs, the gene for gammaS-crystallin, the first mutation to be associated with this gene. A single base change causes replacement of Phe-9, a key hydrophobic …
View article: LINE-1 elements and X chromosome inactivation: A function for “junk” DNA?
LINE-1 elements and X chromosome inactivation: A function for “junk” DNA? Open
Proceedings of the National Academy of Sciences (PNAS), a peer reviewed journal of the National Academy of Sciences (NAS) - an authoritative source of high-impact, original research that broadly spans the biological, physical, and social s…
View article: Narrowing the Critical Regions for Mouse <i>t</i> Complex Transmission Ratio Distortion Factors by Use of Deletions
Narrowing the Critical Regions for Mouse <i>t</i> Complex Transmission Ratio Distortion Factors by Use of Deletions Open
Previously a deletion in mouse chromosome 17, T22H, was shown to behave like a t allele of the t complex distorter gene Tcd1, and this was attributed to deletion of this locus. Seven further deletions are studied here, with the aim of narr…
View article: A UK-centric history of studies on the mouse t-complex
A UK-centric history of studies on the mouse t-complex Open
Early work on the mouse t-complex was well reviewed by Gruneberg (1943), then reader in genetics at University College, London. The Brachyury or T-locus was discovered by Dobrovolskaia-Zavadskaia in Paris in 1927. Animals heterozygous for …
View article: Bruce Cattanach: Mutagenesis and where it can lead you
Bruce Cattanach: Mutagenesis and where it can lead you Open
This Special Issue of Genetical Research constitutes a tribute to the work and achievements of Bruce Cattanach on the occasion of his official retirement. Bruce began his career working on mutagenesis in mice. His interest in mutagenesis c…
View article: Deletion Mapping of the Head Tilt (het) Gene in Mice: A Vestibular Mutation Causing Specific Absence of Otoliths
Deletion Mapping of the Head Tilt (het) Gene in Mice: A Vestibular Mutation Causing Specific Absence of Otoliths Open
Head tilt (het) is a recessive mutation in mice causing vestibular dysfunction. Homozygotes display abnormal responses to position change and linear acceleration and cannot swim. However, they are not deaf. het was mapped to the proximal r…
View article: An 85-kb tandem triplication in the slow Wallerian degeneration ( <i>Wld</i> <sup>s</sup> ) mouse
An 85-kb tandem triplication in the slow Wallerian degeneration ( <i>Wld</i> <sup>s</sup> ) mouse Open
Wallerian degeneration is the degeneration of the distal stump of an injured axon. It normally occurs over a time course of around 24 hr but it is delayed in the slow Wallerian degeneration mutant mouse (C57BL/ Wld s ) for up to 3 weeks. T…
View article: Morphogenesis of <i>Doublefoot</i> (<i>Dbf</i>), a mouse mutant with polydactyly and craniofacial defects
Morphogenesis of <i>Doublefoot</i> (<i>Dbf</i>), a mouse mutant with polydactyly and craniofacial defects Open
We report the morphogenesis of a new mouse mutant, Doublefoot ( Dbf ). The major phenotypic features involve the limb and craniofacial regions. There is polydactyly of all 4 limbs, with typically 6–8 digits per limb. All of the digits are …
View article: Genetic mapping of the doublefoot (<i>Dbf</i>) mutation
Genetic mapping of the doublefoot (<i>Dbf</i>) mutation Open
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View article: Doublefoot: a new mouse mutant affecting development of limbs and head
Doublefoot: a new mouse mutant affecting development of limbs and head Open
Summary The mutant doublefoot, Dbf , of the mouse arose spontaneously, and was shown to be inherited as an autosomal dominant, mapping 9–13 cM proximal to leaden, ln , on chromosome 1 and showing no recombination with the microsatellite ma…
View article: GRH volume 68 issue 3 Cover and Back matter
GRH volume 68 issue 3 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: An additional type of male sterility and inherited urinary obstruction in mice with the<i>t</i>-haplotype<i>t<sup>h7</sup></i>
An additional type of male sterility and inherited urinary obstruction in mice with the<i>t</i>-haplotype<i>t<sup>h7</sup></i> Open
Summary The t -complex on mouse chromosome 17 results in transmission ratio distortion in males heterozygous for complete haplotypes, and sterility in those homozygous for semi-lethal or doubly heterozygous for complementing lethal haploty…
View article: X Chromosome Inactivation and Imprinting
X Chromosome Inactivation and Imprinting Open
In contrast to the random inactivation of either maternal or paternal X-chromosome in the somatic cells of eutherian mammals, in marsupials the paternal X-chromosome is preferentially inactivated in all cells. Similar exclusively paternal …
View article: GRH volume 66 issue 3 Cover and Back matter
GRH volume 66 issue 3 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: GRH volume 65 issue 3 Cover and Back matter
GRH volume 65 issue 3 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: GRH volume 64 issue 3 Cover and Back matter
GRH volume 64 issue 3 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: GRH volume 63 issue 3 Cover and Back matter
GRH volume 63 issue 3 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: GRH volume 62 issue 3 Cover and Back matter
GRH volume 62 issue 3 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
View article: A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4.
A gene affecting Wallerian nerve degeneration maps distally on mouse chromosome 4. Open
When a nerve axon is cut or crushed, the nerve fibers in the distal part of the axon, separated from the cell body, undergo a form of spontaneous degeneration, known as Wallerian degeneration. A substrain of the mouse inbred strain C57BL, …
View article: GRH volume 61 issue 3 Cover and Back matter
GRH volume 61 issue 3 Cover and Back matter Open
An abstract is not available for this content so a preview has been provided. As you have access to this content, a full PDF is available via the ‘Save PDF’ action button.