Mary Pitman
YOU?
Author Swipe
View article: Systematic analysis of the RGS2 degron reveals characteristics of substrate recognition by the F-box protein FBXO44
Systematic analysis of the RGS2 degron reveals characteristics of substrate recognition by the F-box protein FBXO44 Open
Regulator of G protein signaling 2 (RGS2) negatively modulates signaling downstream of G protein-coupled receptors by accelerating GTP hydrolysis at Gα subunits of heterotrimeric G proteins. Decreased RGS2 levels are implicated in numerous…
View article: Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A
Sphingosine simultaneously inhibits nuclear import and activates PP2A by binding importins and PPP2R1A Open
Sphingosine and constrained analogs like FTY720 and SH-BC-893 restrain tumor growth through incompletely defined mechanisms that include protein phosphatase 2A (PP2A) activation. Here we show that these compounds directly bind not only the…
View article: Building Block-Based Binding Predictions for DNA-Encoded Libraries
Building Block-Based Binding Predictions for DNA-Encoded Libraries Open
DNA-encoded libraries (DELs) provide the means to make and screen millions of diverse compounds against a target of interest in a single experiment. However, despite producing large volumes of binding data at a relatively low cost, the DEL…
View article: Building Block-Based Binding Predictions for DNA-Encoded Libraries
Building Block-Based Binding Predictions for DNA-Encoded Libraries Open
DNA-encoded libraries (DELs) provide the means to make and screen millions of diverse compounds against a target of interest in a single experiment. However, despite producing large volumes of binding data at a relatively low cost, the DEL…
View article: To Design Scalable Free Energy Perturbation Networks, Optimal Is Not Enough
To Design Scalable Free Energy Perturbation Networks, Optimal Is Not Enough Open
Drug discovery is accelerated with computational methods such as alchemical simulations to estimate ligand affinities. In particular, relative binding free energy (RBFE) simulations are beneficial for lead optimization. To use RBFE simulat…
View article: To Design Scalable Free Energy Perturbation Networks, Optimal Is Not Enough
To Design Scalable Free Energy Perturbation Networks, Optimal Is Not Enough Open
Drug discovery is accelerated with computational methods such as alchemical simulations to estimate ligand affinities. In particular, relative binding free energy (RBFE) simulations are beneficial for lead optimization. To use RBFE simulat…
View article: EPIGENETICS TUNE CHROMATIN MECHANICS, A COMPUTATIONAL APPROACH
EPIGENETICS TUNE CHROMATIN MECHANICS, A COMPUTATIONAL APPROACH Open
The base unit of DNA packaging in eukaryotes, the nucleosome, is adaptively modified for epigenetic control. Given the vast chemical space of chromatin and complexity of signaling and expression, much of our knowledge about genetic regulat…
View article: Job Opening for Nucleosome Mechanic: Flexibility Required
Job Opening for Nucleosome Mechanic: Flexibility Required Open
The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer’s mechan…
View article: Job Opening for Nucleosome Mechanic: Flexibility Required
Job Opening for Nucleosome Mechanic: Flexibility Required Open
The nucleus has been studied for well over 100 years, and chromatin has been the intense focus of experiments for decades. In this review, we focus on an understudied aspect of chromatin biology, namely the chromatin fiber polymer's mechan…
View article: Minimal Cylinder Analysis Reveals the Mechanical Properties of Oncogenic Nucleosomes
Minimal Cylinder Analysis Reveals the Mechanical Properties of Oncogenic Nucleosomes Open
View article: A Balance Between Elastic and Rigidified CENP-A Nucleosomes Govern Centromeric Chromatin Fidelity
A Balance Between Elastic and Rigidified CENP-A Nucleosomes Govern Centromeric Chromatin Fidelity Open
View article: Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners
Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners Open
Histone variants fine-tune transcription, replication, DNA damage repair, and faithful chromosome segregation. Whether and how nucleosome variants encode unique mechanical properties to their cognate chromatin structures remains elusive. H…
View article: Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners
Intrinsic elasticity of nucleosomes is encoded by histone variants and calibrated by their binding partners Open
Histone variants fine-tune transcription, replication, DNA damage repair, and faithful chromosome segregation. Whether and how nucleosome variants encode unique mechanical properties to their cognate chromatin structures remains elusive. H…
View article: Internal modifications in the CENP-A nucleosome modulate centromeric dynamics
Internal modifications in the CENP-A nucleosome modulate centromeric dynamics Open
View article: Internal modifications in the CENP-A nucleosome modulate centromeric dynamics
Internal modifications in the CENP-A nucleosome modulate centromeric dynamics Open
Post-translational modifications (PTMs) of core histones have studied for over 2 decades, and are correlated with changes in transcriptional status, chromatin fiber folding, and nucleosome dynamics. However, within the centromere-specific …