Rachel Thomson
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View article: Non-tuberculous mycobacterial infection in cystic fibrosis before and after initiation of elexacaftor/tezacaftor/ivacaftor: now is not the time to lower the guard
Non-tuberculous mycobacterial infection in cystic fibrosis before and after initiation of elexacaftor/tezacaftor/ivacaftor: now is not the time to lower the guard Open
Background The prevalence of infection with non-tuberculous mycobacteria (NTM) has been increasing in people with cystic fibrosis (pwCF) over the past 30 years. Emerging reports of beneficial effects of CFTR modulators, particularly elexac…
View article: <i>In vitro</i> efficacy of sulbactam/durlobactam combined with β-lactam antibiotics in Australian <i>Mycobacterium abscessus</i> isolates
<i>In vitro</i> efficacy of sulbactam/durlobactam combined with β-lactam antibiotics in Australian <i>Mycobacterium abscessus</i> isolates Open
Background and objectives Mycobacterium abscessus has extensive innate and acquired antibiotic resistance resulting in limited antibiotic treatment options and poor clinical outcomes. Currently, the only β-lactam antibiotics with efficacy …
View article: The microbiome and gut–lung axis in nontuberculous mycobacterial pulmonary disease
The microbiome and gut–lung axis in nontuberculous mycobacterial pulmonary disease Open
Nontuberculous mycobacterial pulmonary disease (NTM-PD) is increasingly recognised as a significant global health concern. It is characterised by a highly heterogenous clinical course and remains poorly understood, from host susceptibility…
View article: Finding the optimal regimen for <i>Mycobacteroides abscessus</i> treatment (FOR<i>Ma</i>T) in people with <i>Mycobacteroides abscessus</i> pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial
Finding the optimal regimen for <i>Mycobacteroides abscessus</i> treatment (FOR<i>Ma</i>T) in people with <i>Mycobacteroides abscessus</i> pulmonary disease: a multicentre, randomised, multi-arm, adaptive platform trial Open
Introduction Mycobacteroides abscessus (MABS) is within the non-tuberculous mycobacteria family. It inhabits soil and water, exhibits multi-antibiotic resistance and causes opportunistic lung infections, which may progress to symptomatic M…
View article: Management of Nontuberculous Mycobacterial Pulmonary Disease Refractory to Guideline-Based Therapy: A Systematic Review
Management of Nontuberculous Mycobacterial Pulmonary Disease Refractory to Guideline-Based Therapy: A Systematic Review Open
Introduction Managing patients with nontuberculous mycobacterial pulmonary disease (NTM-PD) unresponsive to guideline-based therapy presents a significant clinical challenge. Limited treatment options and the complex nature of disease prog…
View article: Disinfectant and antibiotic resistance in <i>Mycobacterium abscessus</i> water isolates
Disinfectant and antibiotic resistance in <i>Mycobacterium abscessus</i> water isolates Open
Mycobacterium abscessus has been found in drinking water distribution systems worldwide, and infections have been increasing in frequency. The emergence of dominant circulating clones within clinical settings and during chronic disease has…
View article: Evaluating the environmental sustainability of AI in radiology: a systematic review of current practice
Evaluating the environmental sustainability of AI in radiology: a systematic review of current practice Open
Purpose: Data- and energy-heavy artificial intelligence (AI) technologies are increasingly applied in radiology, often without consideration of potential environmental consequences. We aimed to assess current practice in evaluating environ…
View article: Pediatric physiotherapy management of airway clearance therapy and exercise: Data from the Australian Bronchiectasis Registry
Pediatric physiotherapy management of airway clearance therapy and exercise: Data from the Australian Bronchiectasis Registry Open
Background Regular airway clearance techniques (ACTs) and exercise are recommended for children with bronchiectasis, but current clinical practice and their predictors are unknown. Objective We aimed to describe current use of ACTs and exe…
View article: Antibiotic lethality dictates mycobacterial infection outcomes
Antibiotic lethality dictates mycobacterial infection outcomes Open
Antibiotic development and treatment focus on bacterial growth inhibition, often with limited success. Here, we introduce Antimicrobial Single-Cell Testing (ASCT), an advanced imaging strategy to assess bacterial killing in real-time. By t…
View article: Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months
Inhaled colistimethate sodium in patients with bronchiectasis and Pseudomonas aeruginosa infection: results of PROMIS-I and PROMIS-II, two randomised, double-blind, placebo-controlled phase 3 trials assessing safety and efficacy over 12 months Open
Zambon.
View article: Investigating the impact of socioeconomic status on amyotrophic lateral sclerosis
Investigating the impact of socioeconomic status on amyotrophic lateral sclerosis Open
Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by the gradual death of motor neurons in the brain and spinal cord, leading to fatal paralysis. Socioeconomic status (SES) is a measure of an individual's sha…
View article: Current physiotherapy practice for adults with bronchiectasis: Data from the Australian bronchiectasis registry
Current physiotherapy practice for adults with bronchiectasis: Data from the Australian bronchiectasis registry Open
Approximately half the adults in the registry report regular ACT or exercise; QOL and disease severity predict this engagement. This knowledge may guide the tailoring of ACTs and exercise prescription to optimise physiotherapy management i…
View article: Extended water stagnation in buildings during the COVID-19 pandemic increases the risks posed by opportunistic pathogens
Extended water stagnation in buildings during the COVID-19 pandemic increases the risks posed by opportunistic pathogens Open
The regrowth and subsequent exposure of opportunistic pathogens (OPs) whilst reopening buildings that have been locked down due to the stay-at-home restrictions to limit the spread of COVID-19, is a public health concern. To better underst…
View article: A systematic review of the clinical impact of small colony variants in patients with cystic fibrosis
A systematic review of the clinical impact of small colony variants in patients with cystic fibrosis Open
Background Cystic fibrosis (CF) is a life-limiting disorder that is characterised by respiratory tract inflammation that is mediated by a range of microbial pathogens. Small colony variants (SCVs) of common respiratory pathogens are being …
View article: In vitro susceptibility testing of imipenem-relebactam and tedizolid against 102 Mycobacterium abscessus isolates
In vitro susceptibility testing of imipenem-relebactam and tedizolid against 102 Mycobacterium abscessus isolates Open
This study shows lower MICs for imipenem-relebactam and tedizolid compared to other more commonly used antibiotics and supports their consideration in clinical trials for M. abscessus treatment.
View article: ‘Teach me how to look after myself’: What people with bronchiectasis want from education in a pulmonary rehabilitation setting
‘Teach me how to look after myself’: What people with bronchiectasis want from education in a pulmonary rehabilitation setting Open
Introduction Pulmonary rehabilitation is recommended for people with bronchiectasis. Various education topics are included in these programmes, but the content is largely guided by the needs of people with other respiratory conditions. Obj…
View article: Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease
Characterizing and correcting immune dysfunction in non-tuberculous mycobacterial disease Open
Non-tuberculous mycobacterial pulmonary disease (NTM-PD) is a chronic, progressive, and growing worldwide health burden associated with mounting morbidity, mortality, and economic costs. Improvements in NTM-PD management are urgently neede…
View article: Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Drug Treatment of Non-Tuberculous Mycobacteria in Cystic Fibrosis
Clinical Pharmacokinetic and Pharmacodynamic Considerations in the Drug Treatment of Non-Tuberculous Mycobacteria in Cystic Fibrosis Open
Non-tuberculous mycobacteria (NTM) are an emerging group of pulmonary infectious pathogens of increasing importance to the management of patients with cystic fibrosis (CF). NTM include slow-growing mycobacteria such as Mycobacterium avium …
View article: Amikacin Liposome Inhalation Suspension for Refractory Mycobacterium avium Complex Lung Disease
Amikacin Liposome Inhalation Suspension for Refractory Mycobacterium avium Complex Lung Disease Open
ClinicalTrials.gov; No.: NCT02344004; URL: www.clinicaltrials.gov.
View article: Amikacin Liposome Inhalation Suspension for <i>Mycobacterium avium</i> Complex Lung Disease: A 12-Month Open-Label Extension Clinical Trial
Amikacin Liposome Inhalation Suspension for <i>Mycobacterium avium</i> Complex Lung Disease: A 12-Month Open-Label Extension Clinical Trial Open
Rationale: Patients with refractory Mycobacterium avium complex (MAC) lung disease have limited treatment options. In the CONVERT study, amikacin liposome inhalation suspension (ALIS) added to guideline-based therapy (GBT) increased cultur…
View article: Management of Drug Toxicity in <i>Mycobacterium avium</i> Complex Pulmonary Disease: An Expert Panel Survey
Management of Drug Toxicity in <i>Mycobacterium avium</i> Complex Pulmonary Disease: An Expert Panel Survey Open
Adverse events are frequent in nontuberculous mycobacteria pulmonary disease treatment, but evidence to support their management is scarce. An expert panel survey on management of adverse events shows consistent opinions on management of h…
View article: The Rise of Non-Tuberculosis Mycobacterial Lung Disease
The Rise of Non-Tuberculosis Mycobacterial Lung Disease Open
The incidence and number of deaths from non-tuberculous mycobacterial (NTM) disease have been steadily increasing globally. These lesser known "cousins" of Mycobacterium tuberculosis (TB) were once thought to be harmless environmental sapr…