Maryssa Beasley
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View article: Effect of Salts on the Aggregation and Strength of Protein-Based Underwater Adhesives
Effect of Salts on the Aggregation and Strength of Protein-Based Underwater Adhesives Open
While hydrophobic underwater adhesives have often been desired for their ability to remove water from interfaces, their inherent immiscibility with water can also hinder their use. Water-based adhesive systems can lead to improved wetting,…
View article: Whole-genome sequence of <i>Arthrobacter koreensis</i> strain RMB17, isolated as a recurring laboratory contaminant in high-salt media
Whole-genome sequence of <i>Arthrobacter koreensis</i> strain RMB17, isolated as a recurring laboratory contaminant in high-salt media Open
Here we report the whole-genome sequence of Arthrobacter koreensis strain RMB17, an actinobacterium isolated as a recurring laboratory contaminant during marine bacteria cultivation in high-salt medium. The 3.4 Mbp genome was sequenced in …
View article: Lipid production from biofilms of Marinobacter atlanticus in a fixed bed bioreactor
Lipid production from biofilms of Marinobacter atlanticus in a fixed bed bioreactor Open
Background Biotechnologies that utilize microorganisms as production hosts for lipid synthesis will enable an efficient and sustainable solution to produce lipids, decreasing reliance on traditional routes for production (either petrochemi…
View article: Blocking the ability of huntingtin to bind membranes: a therapeutic strategy for Huntington’s disease
Blocking the ability of huntingtin to bind membranes: a therapeutic strategy for Huntington’s disease Open
The ordered aggregation of proteins into amyloid fibrils is a hallmark of numerous neurodegenerative diseases. A common strategy in developing therapeutics for amyloid-based diseases relies on preventing or manipulating the aggregation pro…
View article: Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation
Cholesterol impacts the formation of huntingtin/lipid complexes and subsequent aggregation Open
Huntington's disease (HD) is a neurodegenerative disease resulting from an expansion of the polyglutamine (polyQ) domain within the huntingtin protein (htt). PolyQ expansion triggers toxic aggregation and alters htt/lipid interactions. The…
View article: Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt
Nucleation Inhibition of Huntingtin Protein (htt) by Polyproline PPII Helices: A Potential Interaction with the N-Terminal α-Helical Region of Htt Open
Huntington's disease is a genetic neurodegenerative disorder characterized by the formation of amyloid fibrils of the huntingtin protein (htt). The 17-residue N-terminal region of htt (Nt17) has been implicated in the formation of early ph…
View article: Investigating the interactions of the first 17 amino acid residues of Huntingtin with lipid vesicles using mass spectrometry and molecular dynamics
Investigating the interactions of the first 17 amino acid residues of Huntingtin with lipid vesicles using mass spectrometry and molecular dynamics Open
The first 17 amino acid residues of Huntingtin protein (Nt17 of htt) are thought to play an important role in the protein's function; Nt17 is one of two membrane binding domains in htt. In this study the binding ability of Nt17 peptide wit…
View article: Lipid Membranes Influence the Ability of Small Molecules To Inhibit Huntingtin Fibrillization
Lipid Membranes Influence the Ability of Small Molecules To Inhibit Huntingtin Fibrillization Open
Several diseases, including Alzheimer's disease, Parkinson's disease, and Huntington's disease (HD), are associated with specific proteins aggregating and depositing within tissues and/or cellular compartments. The aggregation of these pro…