Muhammed Majeed
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View article: Comparative LC-MS Chemical Fingerprinting, Antioxidant Potential, and <i>in Silico</i> Analysis of Anti-Emetic and Pain Modulation Activity of dry and Fresh White Ginger Extracts
Comparative LC-MS Chemical Fingerprinting, Antioxidant Potential, and <i>in Silico</i> Analysis of Anti-Emetic and Pain Modulation Activity of dry and Fresh White Ginger Extracts Open
Objective Ginger ( Zingiber officinale ) is well known for its therapeutic properties, particularly its anti-emetic effects and pain modulation potential. The research on nausea and pain modulation has primarily focused on ginger and shoga…
View article: Current Practice Patterns in the Management of Bell's Palsy Among Physiotherapists of Sargodha, Pakistan
Current Practice Patterns in the Management of Bell's Palsy Among Physiotherapists of Sargodha, Pakistan Open
Objectives: We intend to find out current practice patterns in managing Bell’s palsy among the physiotherapists of Sargodha, Pakistan. Methods: A cross-sectional study was conducted from May to August 2022. Data were obtained from 50 physi…
View article: THE WEAPONIZATION OF INFORMATION: HOW DISINFORMATION CAMPAIGNS UNDERMINE SELF-DETERMINATION
THE WEAPONIZATION OF INFORMATION: HOW DISINFORMATION CAMPAIGNS UNDERMINE SELF-DETERMINATION Open
This research paper examines how disinformation campaigns harm self-determination processes by examining the psychological mechanisms by which public opinion can be manipulated, including confirmation bias and emotional manipulation. This …
View article: Study of the Effects of Novel Analogs of Calebin-A on Melanogenesis
Study of the Effects of Novel Analogs of Calebin-A on Melanogenesis Open
In our previous study, we documented the anti-melanogenic efficacy of calebin-A (CBA), which is a curcuminoid analog. The effects of its newly synthesized analogs, i.e., bisdemethoxy calebin (BD), demethoxycalebin-1 (DA1), demethoxycalebin…
View article: The Neuroprotective Effects of Oroxylum indicum Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression under LPS Induced Inflammation
The Neuroprotective Effects of Oroxylum indicum Extract in SHSY-5Y Neuronal Cells by Upregulating BDNF Gene Expression under LPS Induced Inflammation Open
The brain-derived neurotrophic factor (BDNF) plays a crucial role during neuronal development as well as during differentiation and synaptogenesis. They are important proteins present in the brain that support neuronal health and protect t…
View article: Effect of Calebin-A on Critical Genes Related to NAFLD: AProtein-Protein Interaction Network and Molecular Docking Study
Effect of Calebin-A on Critical Genes Related to NAFLD: AProtein-Protein Interaction Network and Molecular Docking Study Open
Background:: Calebin-A is a minor phytoconstituent of turmeric known for its activity against inflammation, oxidative stress, cancerous, and metabolic disorders like Non-alcoholic fatty liver disease(NAFLD). Based on bioinformatic tools. S…
View article: Probiotic Weizmannia coagulans MTCC 5856 as adjunct therapy in children's acute diarrhea—a randomized, double-blind, placebo-controlled study
Probiotic Weizmannia coagulans MTCC 5856 as adjunct therapy in children's acute diarrhea—a randomized, double-blind, placebo-controlled study Open
Objectives Acute diarrhea in children is generally managed by replacing the lost fluid with oral rehydration solution (ORS). Probiotic supplementation has been reported to reduce the severity of diarrhea. In the present study, we investiga…
View article: Enhancement in Bioavailability of CurCousin&lt;sup&gt;&amp;reg;&lt;/sup&gt;, A Minor Metabolite from &lt;i&gt;Curcuma longa&lt;/i&gt; by Addition of BioPerine&lt;sup&gt;&amp;reg;&lt;/sup&gt; &lt;br/&gt;—A Pharmacokinetic Study
Enhancement in Bioavailability of CurCousin<sup>&reg;</sup>, A Minor Metabolite from <i>Curcuma longa</i> by Addition of BioPerine<sup>&reg;</sup> <br/>—A Pharmacokinetic Study Open
In recent years, metabolic syndrome has been a growing health concern across the world. The role of nutraceuticals and functional foods in this area has a significant place due to the adverse effects of contemporary modes of treatment. Cur…
View article: The Mechanism of Anti-Viral Activity of a Novel, Hydroponically Selenium-Enriched Garlic Powder (SelenoForce<sup>®</sup>) Against SARS-CoV-2 Virus
The Mechanism of Anti-Viral Activity of a Novel, Hydroponically Selenium-Enriched Garlic Powder (SelenoForce<sup>®</sup>) Against SARS-CoV-2 Virus Open
The pandemic caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is far from over as new strains are emerging all over the world. Selenium as a micronutrient is important for immunity and also has anti-viral activity…
View article: The efficacy of curcumin-piperine supplementation in patients with nonproliferative diabetic retinopathy: An optical coherence tomography angiography-based randomized controlled trial.
The efficacy of curcumin-piperine supplementation in patients with nonproliferative diabetic retinopathy: An optical coherence tomography angiography-based randomized controlled trial. Open
Curcumin-piperine is effective in improving oxidative stress and reducing creatinine in DR. Further trials are necessary to confirm these promising findings.
View article: A scientifically validated combination of garcinol, curcuminoids, and piperine for mild to moderate nonalcoholic steatohepatitis patients—results from a randomized, double-blind, placebo-controlled study
A scientifically validated combination of garcinol, curcuminoids, and piperine for mild to moderate nonalcoholic steatohepatitis patients—results from a randomized, double-blind, placebo-controlled study Open
Background Garcinol is a naturally occurring compound from the fruit rind of the Garcinia indica , with antioxidant, anti-inflammatory, and anticancer properties. Curcuminoids are the active molecule from the rhizome of Curcuma longa , stu…
View article: The Effects of Antioxidants and Pulsed Magnetic Fields on Slow and Fast Skeletal Muscle Atrophy Induced by Streptozotocin: A Preclinical Study
The Effects of Antioxidants and Pulsed Magnetic Fields on Slow and Fast Skeletal Muscle Atrophy Induced by Streptozotocin: A Preclinical Study Open
Background and Objectives. Skeletal muscle atrophy, a condition characterized by decreased muscle mass and contractility, is commonly observed in various pathological states, including prolonged inactivity, malnutrition, sarcopenia, and ty…
View article: Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa
Assessment of Safety Profile of Activated Curcumin C3 Complex (AC3®), Enriched Extract of Bisdemethoxycurcumin from the Rhizomes of Curcuma longa Open
The present work was carried out to investigate the toxic effects of Activated Curcumin C3 Complex (AC3®) through the methods of acute, subacute, subchronic, reproductive/developmental toxicity, and genotoxicity when administered orally in…
View article: A Standardized <i>Withania somnifera</i> (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study
A Standardized <i>Withania somnifera</i> (Linn.) Root Extract with Piperine Alleviates the Symptoms of Anxiety and Depression by Increasing Serotonin Levels: A Double-Blind, Randomized, Placebo-Controlled Study Open
(Linn) or Ashwagandha is used in Ayurveda and other traditional medicine systems as an adaptogen and a neuroprotective supplement.
View article: A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study
A standardized Ashwagandha root extract alleviates stress, anxiety, and improves quality of life in healthy adults by modulating stress hormones: Results from a randomized, double-blind, placebo-controlled study Open
Background: The coronavirus disease-2019 (COVID-19) pandemic has resulted in a surge in stress, anxiety, and depression worldwide. Ashwagandha, an ayurvedic adaptogen has been traditionally used to manage stress, anxiety, and general well-…
View article: Super Fruit Amla (Emblica officinalis, Gaertn) in Diabetes Management and Ensuing Complications: A Concise Review
Super Fruit Amla (Emblica officinalis, Gaertn) in Diabetes Management and Ensuing Complications: A Concise Review Open
Type 2 diabetes mellitus (T2DM) is a chronic metabolic disease showing an exponential increase in its prevalence all over the world. High blood glucose level is one of the main clinical signs of the disease. Although several classes of dru…
View article: CCDC 2211281: Experimental Crystal Structure Determination
CCDC 2211281: Experimental Crystal Structure Determination Open
An entry from the Cambridge Structural Database, the world’s repository for small molecule crystal structures. The entry contains experimental data from a crystal diffraction study. The deposited dataset for this entry is freely available …
View article: The impact of curcumin on migraine: A comprehensive review
The impact of curcumin on migraine: A comprehensive review Open
Migraine, a neurovascular condition, is a chronic and lifelong disease that affects about 15% of the population worldwide. Although the exact pathophysiology and etiology of migraine are still unclear, oxidative stress, inflammation, and n…
View article: Probiotic modulation of gut microbiota by Bacillus coagulans MTCC 5856 in healthy subjects: A randomized, double-blind, placebo-control study
Probiotic modulation of gut microbiota by Bacillus coagulans MTCC 5856 in healthy subjects: A randomized, double-blind, placebo-control study Open
Background: Probiotics are known to rebalance the gut microbiota in dysbiotic individuals, but their impact on the gut microbiome of healthy individuals is seldom studied. The current study is designed to assess the impact and safety of Ba…
View article: The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study
The effects of Bacillus coagulans MTCC 5856 on functional gas and bloating in adults: A randomized, double-blind, placebo-controlled study Open
Background: Gut microbiome dysbiosis is a major cause of abdominal gas, bloating, and distension. Bacillus coagulans MTCC 5856 (LactoSpore) is a spore-forming, thermostable, lactic acid-producing probiotic that has numerous health benefits…
View article: A Randomized Double-Blind, Placebo-Controlled Study to Evaluate the Anti-Skin-Aging Effect of LactoSporin – The Extracellular Metabolite from Bacillus coagulans (Weizmannia coagulans) MTCC 5856 in Healthy Female Volunteers
A Randomized Double-Blind, Placebo-Controlled Study to Evaluate the Anti-Skin-Aging Effect of LactoSporin – The Extracellular Metabolite from Bacillus coagulans (Weizmannia coagulans) MTCC 5856 in Healthy Female Volunteers Open
These results suggest that LactoSporin could be a safe natural ingredient to reduce wrinkles and fine lines in cosmetic formulations.
View article: Evaluation of Pharmacokinetic Profile of Cirpusins®, Extract of Cyperus rotundus in Presence of Bioavailability Enhancer, BioPerine®
Evaluation of Pharmacokinetic Profile of Cirpusins®, Extract of Cyperus rotundus in Presence of Bioavailability Enhancer, BioPerine® Open
Obesity, a condition accompanying abnormal or excessive accumulation of fat in the body has become a major public health concern globally. Various herbs hailed from traditional systems of medicine like Ayurveda have gained importance in re…
View article: Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies
Curcumin‐piperine co‐supplementation and human health: A comprehensive review of preclinical and clinical studies Open
Curcumin is extracted from the rhizomes Curcuma longa L. It is known for its anti‐inflammatory and anti‐oxidant activities. Despite its safety and potential for use against various diseases, curcumin's utility is restricted due to its low …
View article: A minor metabolite from<i>Curcuma longa</i>effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study
A minor metabolite from<i>Curcuma longa</i>effective against metabolic syndrome: results from a randomized, double-blind, placebo-controlled clinical study Open
Randomized clinical trials show higher efficacy of Calebin A in managing metabolic syndrome in obese individuals.
View article: The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial.
The effect of curcumin-piperine on cardiometabolic, inflammatory and oxidative stress factors and macular vascular density in optical coherence tomography angiography (OCTA) in patients with non-proliferative diabetic retinopathy: Study protocol for a randomized, double-blind controlled trial. Open
If the beneficial effects of curcumin on diabetic retinopathy are observed, this safe, this natural and inexpensive herbal supplement can be considered a therapeutic solution in these patients.
View article: A Short-Term Safety Evaluation of Silbinol<sup>®</sup>- an Extract from <i>Pterocarpus marsupium</i> in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study
A Short-Term Safety Evaluation of Silbinol<sup>®</sup>- an Extract from <i>Pterocarpus marsupium</i> in Healthy Adults- a Randomized, Double-Blind, Placebo-Controlled Study Open
Background: Pterostilbene is an active molecule from the bark of the Pterocarpus marsupium tree with antioxidant and anti-inflammatory properties. Objective: This study aimed to evaluate the clinical safety of a standardized P. marsupium e…