Explanipedia

Correction: Androgens as the “old age stick” in skeletal muscle Open

Giulia Gentile, Ferdinando De Stefano, Carmela Sorrentino, Rosa D’Angiolo, Carmine Lauretta , et al. · 2025

Role of the androgen receptor in melanoma aggressiveness Open

Marzia Di Donato, Costanza Maria Cristiani, Mariaelena Capone, Cinzia Garofalo, Gabriele Madonna , et al. · 2025

Molecular Mechanisms in Melanoma: Investigating the Role of MicroRNAs Open

Noemi Cavallo, Marta Moscedano, Giuliana Giamundo, Concetta Barone, Iolanda Carratù , et al. · 2025

Editorial: A new era: shaping women's metabolic health, fertility, and sex-related cancers Open

Costanza Maria Cristiani, Gustavo Cernera, Marzia Di Donato · 2024

EDITORIAL article Front. Nutr., 13 March 2024Sec. Nutrition and Metabolism Volume 11 - 2024 | https://doi.org/10.3389/fnut.2024.1371975

Filamin A in triple negative breast cancer Open

Pia Giovannelli, Marzia Di Donato, Fabrizio Licitra, Emilia Sabbatino, Viviana Tutino , et al. · 2024

Triple-negative breast cancer is a rare but highly heterogeneous breast cancer subtype with a limited choice of specific treatments. Chemotherapy remains the only efficient treatment, but its side effects and the development of resistance …

Filamin A cooperates with the androgen receptor in preventing skeletal muscle senescence Open

Marzia Di Donato, Antimo Moretti, Carmela Sorrentino, Giuseppe Toro, Giulia Gentile , et al. · 2023

Aging induces a slow and progressive decrease in muscle mass and function, causing sarcopenia. Androgens control muscle trophism and exert important anabolic functions through the binding to the androgen receptor. Therefore, analysis of th…

RIZ2 at the crossroad of the EGF/EGFR signaling in colorectal cancer Open

Marzia Di Donato, Erika Di Zazzo, Annamaria Salvati, Carmela Sorrentino, Giorgio Giurato , et al. · 2023

Background Colorectal cancer (CRC) is the third most deadly and fourth most diagnosed cancer worldwide. Despite the progress in early diagnosis and advanced therapeutic options, CRC shows a poor prognosis with a 5 year survival rate of ~ 4…

Exosomes: Emerging Modulators of Pancreatic Cancer Drug Resistance Open

Marzia Di Donato, Nicola Medici, Antimo Migliaccio, Gabriella Castoria, Pia Giovannelli · 2023

Pancreatic cancer (PaC) is one of the most lethal tumors worldwide, difficult to diagnose, and with inadequate therapeutical chances. The most used therapy is gemcitabine, alone or in combination with nanoparticle albumin-bound paclitaxel …

Review of: "Targeting Cancer Cell Signaling Using Precision Oncology Towards a Holistic Approach to Cancer Therapeutics" Open

Marzia Di Donato · 2023

Potential competing interests: No potential competing interests to declare.This review is the result of a hard research effort.It's really well done and I find it very interesting.The only aspect that is not very detailed is the role of th…

Role of the Androgen Receptor in Gender-Related Cancers Open

Emilia Sabbatino, Viviana Tutino, Fabrizio Licitra, Marzia Di Donato, Gabriella Castoria , et al. · 2023

The androgen receptor (AR) is expressed in many cell types, and its related signaling is widely investigated in hormone-dependent cancers such as prostate and breast. The significance of the AR, however, has been detected even in other can…

The Androgen Regulation of Matrix Metalloproteases in Prostate Cancer and Its Related Tumor Microenvironment Open

Carmela Sorrentino, Rosa D’Angiolo, Giulia Gentile, Pia Giovannelli, Bruno Perillo , et al. · 2023

Prostate cancer represents the most common type of cancer among males and the second leading cause of cancer death in men in Western society. In most cases (~70%), PC has a slow and symptom-free growth, whereas it is more aggressive in the…

The Role of the Androgen Receptor in Skeletal Muscle and Its Utility as a Target for Restoring Muscle Functions Open

Carmela Sorrentino, Giulia Gentile, Rosa D’Angiolo, Carmela Barra, Ferdinando De Stefano , et al. · 2023

Aging is accompanied by a progressive decrease in skeletal muscle mass and function. This process is characterized by the decrease of sex steroid hormone levels due to andropause and menopause. The axis androgens/androgen receptor (AR) sus…

The nerve growth factor-delivered signals in prostate cancer and its associated microenvironment: when the dialogue replaces the monologue Open

Marzia Di Donato, Pia Giovannelli, Antimo Migliaccio, Gabriella Castoria · 2023

Prostate cancer (PC) represents the most diagnosed and the second most lethal cancer in men worldwide. Its development and progression occur in concert with alterations in the surrounding tumor microenvironment (TME), made up of stromal ce…

The Nerve-Growth Factor Signaling in Gender-Related Cancers Open

Marzia Di Donato, Giovanni Galasso, Gustavo Cernera, Antimo Migliaccio, Gabriella Castoria · 2023

The nerve-growth factor (NGF) was initially identified as a promoter of neuronal survival and differentiation. As such, it has captured the interest of neurobiologists for a long time. Nowadays, NGF is considered a multifaceted molecule wi…

New Approaches Targeting the Invasive Phenotype of Prostate Cancer-Associated Fibroblasts Open

Marzia Di Donato, Pia Giovannelli, Antimo Migliaccio, Gabriella Castoria · 2023

Prostate cancer (PC) is one of the most widespread malignancies among males worldwide. The androgen receptor (AR) drives its development and progression and still represents the main target of PC therapy. Second-generation antiandrogens ha…

Editorial: March 2022: Ovarian and prostate cancer awareness month Open

Marzia Di Donato · 2023

EDITORIAL article Front. Endocrinol., 13 February 2023Sec. Cancer Endocrinology Volume 14 - 2023 | https://doi.org/10.3389/fendo.2023.1133963

Androgens and NGF Mediate the Neurite-Outgrowth through Inactivation of RhoA Open

Marzia Di Donato, Antonio Bilancio, Ferdinando Auricchio, Gabriella Castoria, Antimo Migliaccio · 2023

Steroid hormones and growth factors control neuritogenesis through their cognate receptors under physiological and pathological conditions. We have already shown that nerve growth factor and androgens induce neurite outgrowth of PC12 cells…

Androgen receptor Sanger sequencing melanoma cell lines Open

Marzia Di Donato · 2023

Sanger sequencing of Androgen receptor in 3 different melanoma cell lines: AMM16, WM 266-4, Mel Cal

Agri-Food By-Products in Cancer: New Targets and Strategies Open

Carmela Sorrentino, Martina Di Gisi, Giulia Gentile, Fabrizio Licitra, Rosa D’Angiolo , et al. · 2022

The globalization and the changes in consumer lifestyles are forcing us to face a deep transformation in food demand and in the organization of the entire food production system. In this new era, the food-loss and food-waste security nexus…

Inhibition of Vps34 and p110δ PI3K Impairs Migration, Invasion and Three-Dimensional Spheroid Growth in Breast Cancer Cells Open

Marzia Di Donato, Pia Giovannelli, Antimo Migliaccio, Antonio Bilancio · 2022

Breast cancer is a heterogeneous disease that represents the most common cancer around the world; it comprises 12% of new cases according to the World Health Organization. Despite new approaches in early diagnosis and current treatment, br…

Editorial: Targeting Estrogens in Cancer Care Open

Marzia Di Donato · 2022

EDITORIAL article Front. Oncol., 11 July 2022Sec. Molecular and Cellular Oncology Volume 12 - 2022 | https://doi.org/10.3389/fonc.2022.935938

The Role of Curcumin in Prostate Cancer Cells and Derived Spheroids Open

Mariarosaria Boccellino, Pasqualina Ambrosio, Andrea Ballini, Danila De Vito, Salvatore Scacco , et al. · 2022

A major challenge in the clinical management of prostate cancer (PC) is to inhibit tumor growth and prevent metastatic spreading. In recent years, considerable efforts have been made to discover new compounds useful for PC therapy, and pro…

P-272 Estrogen receptors influence the epithelial-to-mesenchymal transition of pancreatic cancer cell lines Open

Fabrizio Licitra, Pia Giovannelli, Marzia Di Donato, Viviana Tutino, Antimo Migliaccio , et al. · 2022

New TRPM8 blockers exert anticancer activity over castration-resistant prostate cancer models Open

Veronica Di Sarno, Pia Giovannelli, Alicia Medina-Peris, Tania Ciaglia, Marzia Di Donato , et al. · 2022

Editorial: The Role of Steroid Hormones and Growth Factors in Cancer Open

Gustavo Cernera, Marzia Di Donato, Paul J. Higgins, Isabel R. Schlaepfer · 2022

EDITORIAL article Front. Cell Dev. Biol., 12 April 2022Sec. Cancer Cell Biology https://doi.org/10.3389/fcell.2022.887529

Targeting ERβ to fight melanoma: a new valid approach? Open

Marzia Di Donato, Antimo Migliaccio, Gabriella Castoria · 2022

New Insights and Emerging Therapeutic Approaches in Prostate Cancer Open

Fabrizio Licitra, Pia Giovannelli, Marzia Di Donato, Alessandra Monaco, Giovanni Galasso , et al. · 2022

Prostate cancer is the second most frequently diagnosed cancer in men and several therapeutic approaches are currently available for patient’s care. Although the androgen receptor status represents a good predictor of response to androgen …

New TRPM8 Blockers Exert Anticancer Activity Over Castration-Resistant Prostate Cancer Models Open

Veronica Di Sarno, Pia Giovannelli, Alicia Medina-Peris, Tania Ciaglia, Marzia Di Donato , et al. · 2022

A Small Peptide Targeting the Ligand-Induced Androgen Receptor/Filamin a Interaction Inhibits the Invasive Phenotype of Prostate Cancer Cells Open

Marzia Di Donato, Pia Giovannelli, Maria Vittoria Barone, Ferdinando Auricchio, Gabriella Castoria , et al. · 2021

Prostate cancer (PC) is one of the most widespread malignancies among males worldwide. The androgen receptor (AR) plays a major role in prostate cancer development and progression and is the main target of PC therapy. Nonetheless, its acti…

Therapeutic potential of TRPM8 antagonists in prostate cancer Open

Marzia Di Donato, Carmine Ostacolo, Pia Giovannelli, Veronica Di Sarno, Isabel M. Gomez Monterrey , et al. · 2021

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