2023-07-28
Sedation Therapy in Intensive Care Units: Harnessing the Power of Antioxidants to Combat Oxidative Stress
2023-07-28 • Gen Inoue, Yuhei Ohtaki, Kazue Satoh, Yuki Odanaka, Akihito Katoh, Keisuke Suzuki, Yoshitake Tomita, Manabu Eiraku, Kazuki Kikuchi, Kouhei Harano,...
In critically ill patients requiring intensive care, increased oxidative stress plays an important role in pathogenesis. Sedatives are widely used for sedation in many of these patients. Some sedatives are known antioxidants. However, no studies have evaluated the direct scavenging activity of various sedative agents on different free radicals. This study aimed to determine whether common sedatives (propofol, thiopental, and dexmedetomidine (DEX)) have direct free radical scavenging activity against various free r…