Masahiro Iijima
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View article: Clinical characteristics and social burden of menstrual migraine in Japan: an online-based cross-sectional questionnaire study
Clinical characteristics and social burden of menstrual migraine in Japan: an online-based cross-sectional questionnaire study Open
This study highlights the significant burden of MM, demonstrating increased pain intensity, longer pain duration and higher headache frequency during perimenstrual period, accompanied by a concurrent increase in social burden compared to n…
View article: Clinical practice for migraine treatment and characteristics of medical facilities and physicians treating migraine: Insights from a retrospective cohort study using a Japanese claims database
Clinical practice for migraine treatment and characteristics of medical facilities and physicians treating migraine: Insights from a retrospective cohort study using a Japanese claims database Open
The real-world treatment patterns at medical facilities and their physicians’ specialties treating migraine have not been fully investigated in Japan. Therefore, a retrospective cohort study aimed to describe real-world clinical practice a…
View article: Treatment patterns and characteristics of patients with migraine: results from a retrospective database study in Japan
Treatment patterns and characteristics of patients with migraine: results from a retrospective database study in Japan Open
Background Clinical characteristics and treatment practice of patients with migraine in Japan in real-world setting have not been fully investigated. We conducted a retrospective cohort study using claims database to understand the clinica…
View article: Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies
Autoantibodies Against Dihydrolipoamide S-Acetyltransferase in Immune-Mediated Neuropathies Open
Reactivity to DLAT was confirmed in patient sera, mainly in patients with CIDP. DLAT is highly expressed in the dorsal root ganglion cells, and anti-DLAT antibody may serve as a biomarker for sensory-dominant neuropathies.
View article: Aberrant Expression of Nodal and Paranodal Molecules in Neuropathy Associated With IgM Monoclonal Gammopathy With Anti-Myelin-Associated Glycoprotein Antibodies
Aberrant Expression of Nodal and Paranodal Molecules in Neuropathy Associated With IgM Monoclonal Gammopathy With Anti-Myelin-Associated Glycoprotein Antibodies Open
To clarify the pathogenesis of anti-myelin-associated glycoprotein (MAG) antibody neuropathy associated with IgM monoclonal gammopathy (anti-MAG neuropathy), sural nerve biopsy specimens from 15 patients were investigated. Sodium channels,…
View article: Treatment of chronic inflammatory demyelinating polyradiculoneuropathy patients with antibodies against paranodal proteins
Treatment of chronic inflammatory demyelinating polyradiculoneuropathy patients with antibodies against paranodal proteins Open
Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an acquired immune‐mediated polyneuropathy characterized by relapsing or steadily progressive clinical course. A major feature of the syndrome is that it encompasses sever…
View article: Efficacy and Safety of Rituximab in Refractory CIDP With or Without IgG4 Autoantibodies (RECIPE): Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial
Efficacy and Safety of Rituximab in Refractory CIDP With or Without IgG4 Autoantibodies (RECIPE): Protocol for a Double-Blind, Randomized, Placebo-Controlled Clinical Trial Open
Background Chronic inflammatory demyelinating polyradiculoneuropathy (CIDP) is an immune-mediated peripheral neuropathy that is currently classified into several clinical subtypes, which are presumed to have different pathogenic mechanisms…
View article: Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma
Demyelinating Neuropathy Due to Intravascular Large B-cell Lymphoma Open
We herein report the case of a 67-year-old man who presented with the acute onset of limb weakness. Brain magnetic resonance imaging revealed multiple abnormal-signal-intensity lesions. Steroids were administered, and the patient initially…
View article: Clinicopathological spectrum and recent advances in the treatment of hereditary transthyretin amyloidosis
Clinicopathological spectrum and recent advances in the treatment of hereditary transthyretin amyloidosis Open
Hereditary transthyretin (ATTRv) amyloidosis, also known as familial amyloid polyneuropathy, is a disease caused by the systemic deposition of variant transthyretin (TTR). Although this disease was primarily indigenous to endemic foci in P…
View article: Widespread Cardiac and Vasomotor Autonomic Dysfunction in Non-Val30Met Hereditary Transthyretin Amyloidosis
Widespread Cardiac and Vasomotor Autonomic Dysfunction in Non-Val30Met Hereditary Transthyretin Amyloidosis Open
Objective The autonomic functions of hereditary transthyretin (ATTRm) amyloidosis, traditionally referred to as familial amyloid polyneuropathy, have primarily been investigated in patients with Val30Met mutations, and information regardin…
View article: Intravenous immunoglobulin for maintenance treatment of multifocal motor neuropathy: A multi‐center, open‐label, 52‐week phase 3 trial
Intravenous immunoglobulin for maintenance treatment of multifocal motor neuropathy: A multi‐center, open‐label, 52‐week phase 3 trial Open
Intravenous immunoglobulin (IVIg) therapy is currently the only established treatment in patients with multifocal motor neuropathy (MMN), and many patients have an IVIg‐dependent fluctuation. We aimed to investigate the efficacy and safety…
View article: Restoration of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin 155 Antibodies: Follow-up of a Case over 23 Years
Restoration of a Conduction Block after the Long-term Treatment of CIDP with Anti-neurofascin 155 Antibodies: Follow-up of a Case over 23 Years Open
We herein report a woman with chronic inflammatory demyelinating polyneuropathy (CIDP) in whom positivity for anti-neurofascin 155 antibodies was revealed 23 years after the onset of neuropathy. The patient initially reported numbness in t…
View article: Distinct pathogenesis in nonsystemic vasculitic neuropathy and microscopic polyangiitis
Distinct pathogenesis in nonsystemic vasculitic neuropathy and microscopic polyangiitis Open
NSVN and MPA have distinct mechanisms of vasculitis. In MPA, the attachment of neutrophils to vascular endothelial cells seems to be an initial lesion of vasculitis, regardless of the presence or absence of ANCA. Complement participated in…
View article: Vasculitic Neuropathy Following Exposure to a Glyphosate-based Herbicide
Vasculitic Neuropathy Following Exposure to a Glyphosate-based Herbicide Open
We herein report a case of peripheral neuropathy following exposure to large amounts of glyphosate-based herbicide. A 70-year-old man suffered from pain and purpura in the left sole following exposure to glyphosate-based herbicide. Pain an…
View article: Alcoholic Myelopathy and Nutritional Deficiency
Alcoholic Myelopathy and Nutritional Deficiency Open
A patient with chronic alcoholism presented with myelopathy and low serum folate and cobalamin levels. A 42-year-old alcoholic man had gait disturbance for 4 months. A neurological examination revealed marked spasticity with increased deep…
View article: Clinical Characteristics and Differential Diagnosis of Chronic Inflammatory Demyelinating Polyradiculoneuropathy
Clinical Characteristics and Differential Diagnosis of Chronic Inflammatory Demyelinating Polyradiculoneuropathy Open
の位置づ け 末梢神経障害(ニューロパチー)の分類として，大き く脱髄性ニューロパチーと軸索変性性ニューロパチーに 大別される．脱髄性ニューロパチーは，名前の通り末梢 神経を構成する髄鞘(ミエリン)が障害され，器質的障 害である脱髄にいたり発症する場合と，末梢神経におけ る跳躍伝導にかかわる分子群の障害により脱髄と同様の 症状や所見を呈する場合が想定される．脱髄性ニューロ パチーとしては，
View article: Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis
Gene Expression Profile of Inflammatory Myopathy with Malignancy is Similar to that of Dermatomyositis rather than Polymyositis Open
Objective An association has been reported between inflammatory myopathies (IMs), which include polymyositis (PM) and dermatomyositis (DM), and malignancy, and the concept of cancer-associated myositis (CAM) was recently proposed. We herei…