Masakazu Yamamoto
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View article: Clinically Adult-Onset Nesidioblastosis with Repeated Severe Hypoglycemia, Successfully Treated by Two Times Pancreatectomies. A Rare Case Report.
Clinically Adult-Onset Nesidioblastosis with Repeated Severe Hypoglycemia, Successfully Treated by Two Times Pancreatectomies. A Rare Case Report. Open
Although nesidioblastosis is the most common cause of hyperinsulinemic hypoglycemia in infants, it is rare in adults. Nesidioblastosis is pathologically characterized by diffuse neoformation of the islets of Langerhans islets from the panc…
View article: Comprehensive data of 5085 patients newly diagnosed with colorectal liver metastasis between 2013 and 2017: Fourth report of a nationwide survey in Japan
Comprehensive data of 5085 patients newly diagnosed with colorectal liver metastasis between 2013 and 2017: Fourth report of a nationwide survey in Japan Open
The Joint Committee for Nationwide Survey on colorectal liver metastasis (CRLM) was established to improve treatment outcomes in patients with CRLM. The aim of this study was to evaluate the transition in the characteristics and treatment …
View article: Evaluation of two-stage hepatectomy using portal vein embolization for colorectal liver metastasis: a retrospective nationwide cohort survey in Japan
Evaluation of two-stage hepatectomy using portal vein embolization for colorectal liver metastasis: a retrospective nationwide cohort survey in Japan Open
Introduction: Two-stage hepatectomy (TSH) enables patients to undergo surgery for colorectal liver metastasis (CRLM), which one-stage hepatectomy cannot remove. Although the outcome of TSH has been reported, there is no original report fro…
View article: Immunohistochemical expression of <scp>NRF2</scp> is correlated with the magnitude of inflammation and fibrosis in chronic liver disease
Immunohistochemical expression of <span>NRF2</span> is correlated with the magnitude of inflammation and fibrosis in chronic liver disease Open
Background The nuclear factor E2‐related factor 2–Kelch‐like Ech‐associated protein (NRF2–KEAP1) pathway is a major cellular defense mechanism against oxidative stress. However, the role of NRF2–KEAP1 signaling in the development of chroni…
View article: Transplantation of hybrid adipose-derived stem cell sheet with autologous peritoneum: An in vivo feasibility study
Transplantation of hybrid adipose-derived stem cell sheet with autologous peritoneum: An in vivo feasibility study Open
View article: Supplementary Material for: Long-Term Prognosis and Related Factors in Patients with Cirrhosis Treated with Balloon-Occluded Retrograde Transvenous Obliteration
Supplementary Material for: Long-Term Prognosis and Related Factors in Patients with Cirrhosis Treated with Balloon-Occluded Retrograde Transvenous Obliteration Open
Introduction: Balloon-occluded retrograde transvenous obliteration (BRTO) was developed as an effective treatment for gastric varices in patients with cirrhosis. Because liver fibrosis in these patients is assumed to be advan…
View article: Eine einzigartige dreifache Philadelphia Chromosom-Variante t(4;9;22)(q21;q34;q11.2) bei einem neu diagnostizierten Patienten mit chronischer myeloischer Leukämie in chronischer Phase
Eine einzigartige dreifache Philadelphia Chromosom-Variante t(4;9;22)(q21;q34;q11.2) bei einem neu diagnostizierten Patienten mit chronischer myeloischer Leukämie in chronischer Phase Open
Hintergrund: Die chronische myeloische Leukämie ist eine hämatologische Malignität, die mit der Fusion von zwei Genen einhergeht: BCR und ABL1. Diese Fusion resultiert aus einer Translokation zwischen den Chromosomen 9 und 22, auch als Phi…
View article: Effects of the <scp>COVID</scp>‐19 pandemic on gastroenterological surgeries in 2020: A study using the National Clinical Database of Japan
Effects of the <span>COVID</span>‐19 pandemic on gastroenterological surgeries in 2020: A study using the National Clinical Database of Japan Open
Aim This study aimed to investigate the effect of the coronavirus disease pandemic on the number of surgeries for gastroenterological cancer cases in Japan. Methods The data recorded in the National Clinical Database of Japan between 2018 …
View article: Long-term outcomes of regenerative treatment by endoscopic oral mucosal epithelial cell sheet transplantation for the prevention of esophageal stricture after endoscopic resection
Long-term outcomes of regenerative treatment by endoscopic oral mucosal epithelial cell sheet transplantation for the prevention of esophageal stricture after endoscopic resection Open
We reported the short-term outcomes of a regenerative medical treatment to prevent esophageal stricture after endoscopic submucosal dissection (ESD) using cultured tis oral mucosal epithelial cell sheets. This study investigated the long-t…
View article: Distal Bile Duct Metastasis after Colorectal Cancer Surgery: A Case Report
Distal Bile Duct Metastasis after Colorectal Cancer Surgery: A Case Report Open
大腸癌の遠位胆管転移はまれな病態である．症例は82歳の男性で，80歳時に上行結腸癌，早期胃癌，転移性肝癌に対して回盲部切除，胃部分切除，左肝切除術を施行した．術後補助化学療法としてベバシズマブを併用したS-1+オキサリプラチン療法を行った．術後2年目の経過観察のために施行した腹部造影CTにて遠位胆管に22 mmの造影効果を有する腫瘤を指摘された．MRCPで同部位に欠損像として描出され，PET/CTではFDGの集積が確認された．ERCP下生検で管状腺癌の診断となり，遠位胆管癌…
View article: Automated Bleeding Identification in Surgical Videos Using Deep Learning
Automated Bleeding Identification in Surgical Videos Using Deep Learning Open
Background: Analysis of operative data using convolutional neural networks (CNN) is expected to improve surgeon knowledge and professional skill. Further, the identification of bleeding on surgical videos can lead to improved surgical asse…
View article: Validation study of the <scp>JSHBPS</scp> nomogram for patients with colorectal liver metastases who underwent hepatic resection in the recent era ‐ a nationwide survey in Japan
Validation study of the <span>JSHBPS</span> nomogram for patients with colorectal liver metastases who underwent hepatic resection in the recent era ‐ a nationwide survey in Japan Open
Background The Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS) nomogram was developed to predict disease‐free survival in patients with colorectal liver metastases (CRLM) undergoing upfront hepatectomy. However, the utility …
View article: Surgical Outcomes of Laparoscopic versus Open Hepatectomy for Left Hepatocellular Carcinoma: Propensity Score Analyses Using Retrospective Japanese and Korean Individual Patient Data
Surgical Outcomes of Laparoscopic versus Open Hepatectomy for Left Hepatocellular Carcinoma: Propensity Score Analyses Using Retrospective Japanese and Korean Individual Patient Data Open
Introduction: This study aimed to compare the prognostic impact of laparoscopic left hepatectomy (LLH) with that of open left hepatectomy (OLH) on patient survival after resection of left hepatocellular carcinoma (HCC). Methods: Among the …
View article: Left hepatectomy with suprahepatic inferior vena cava resection and reconstruction under veno-arterial extracorporeal membrane oxygenation for intrahepatic cholangiocarcinoma: a case report
Left hepatectomy with suprahepatic inferior vena cava resection and reconstruction under veno-arterial extracorporeal membrane oxygenation for intrahepatic cholangiocarcinoma: a case report Open
View article: Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea‐Japan collaborative study
Proposal of nomograms to predict clinical outcomes in patients with ampulla of Vater cancer based on the Korea‐Japan collaborative study Open
Background In this study, we aimed to develop and validate a nomogram to predict overall survival (OS) and recurrence‐free survival (RFS) in patients who underwent curative resection of ampulla of Vater (AOV) cancer. This is the first stud…
View article: Comparison of infectious complications after spleen preservation versus splenectomy during laparoscopic distal pancreatectomy for benign or low‐grade malignant pancreatic tumors: A multicenter, propensity score‐matched analysis
Comparison of infectious complications after spleen preservation versus splenectomy during laparoscopic distal pancreatectomy for benign or low‐grade malignant pancreatic tumors: A multicenter, propensity score‐matched analysis Open
Background Previous studies have reported contrasting results regarding the advantages of spleen preservation during laparoscopic distal pancreatectomy (LDP) for preventing infectious complications. Methods A total of 3787 patients who und…
View article: A nationwide certification system to increase the safety of highly advanced hepatobiliary‐pancreatic surgery
A nationwide certification system to increase the safety of highly advanced hepatobiliary‐pancreatic surgery Open
Background To ensure that highly advanced hepatobiliary‐pancreatic surgery (HBPS) is performed safely, the Japanese Society of Hepato‐Biliary‐Pancreatic Surgery (JSHBPS) board certification system for expert surgeons established a safety c…
View article: Examination of the characteristics of long-term survivors among patients with gallbladder cancer with liver metastasis who underwent surgical treatment: a retrospective multicenter study (ACRoS1406)
Examination of the characteristics of long-term survivors among patients with gallbladder cancer with liver metastasis who underwent surgical treatment: a retrospective multicenter study (ACRoS1406) Open
View article: Intrahepatic Cholangiocarcinoma With Neither Intrahepatic Metastasis Nor Lymph Node Metastasis Is the Optimal Indication for Hepatectomy With Adjuvant Therapy
Intrahepatic Cholangiocarcinoma With Neither Intrahepatic Metastasis Nor Lymph Node Metastasis Is the Optimal Indication for Hepatectomy With Adjuvant Therapy Open
Background/Aim: The optimal indication of hepatectomy with adjuvant therapy for intrahepatic cholangiocarcinoma (ICC) has not been evaluated in detail. Patients and Methods: We retrospectively studied 224 patients with ICC who underwent he…
View article: Evaluation of the Significance of Lymphatic, Microvascular and Perineural Invasion in Patients With Pancreatic Neuroendocrine Neoplasms
Evaluation of the Significance of Lymphatic, Microvascular and Perineural Invasion in Patients With Pancreatic Neuroendocrine Neoplasms Open
Background: Some prognostic factors for pancreatic neuroendocrine neoplasms (PanNENs) have been reported; however, the significance of lymphatic, microvascular, and perineural invasion remains unclear. We aimed to clarify the role of these…
View article: A case of pathologically complete response after preoperative chemotherapy in a pancreatic acinar cell carcinoma patient with portal vein tumor thrombosis
A case of pathologically complete response after preoperative chemotherapy in a pancreatic acinar cell carcinoma patient with portal vein tumor thrombosis Open
Preoperative treatment is being proposed as a standard treatment for pancreatic ductal adenocarcinoma though few cases show a pathologically complete response. On the other hand, there is no consensus regarding preoperative chemotherapy fo…
View article: Examination of The Characteristics of Long-Term Survivors Among Patients With Gallbladder Cancer With Liver Metastasis Who Underwent Surgical Treatment: A Retrospective Multicenter Study (ACRoS1406)
Examination of The Characteristics of Long-Term Survivors Among Patients With Gallbladder Cancer With Liver Metastasis Who Underwent Surgical Treatment: A Retrospective Multicenter Study (ACRoS1406) Open
Background: Gallbladder cancer (GBC) with liver metastasis is considered unresectable. However, there have been infrequent reports of long-term survival in patients with GBC and liver metastases. Therefore, we examined the characteristics …
View article: Supplementary Material for: Surgical outcomes of laparoscopic versus open hepatectomy for left hepatocellular carcinoma: Propensity score analyses using retrospective Japanese and Korean individual patient data
Supplementary Material for: Surgical outcomes of laparoscopic versus open hepatectomy for left hepatocellular carcinoma: Propensity score analyses using retrospective Japanese and Korean individual patient data Open
Introduction: This study aimed to compare the prognostic impact of laparoscopic left hepatectomy (LLH) with that of open left hepatectomy (OLH) on patient survival after resection of left hepatocellular carcinoma (HCC). Methods: Among the …
View article: Liver Cancer Study Group of Japan Clinical Practice Guidelines for Intrahepatic Cholangiocarcinoma
Liver Cancer Study Group of Japan Clinical Practice Guidelines for Intrahepatic Cholangiocarcinoma Open
This paper presents the first version of clinical practice guidelines for intrahepatic cholangiocarcinoma (ICC) established by the Liver Cancer Study Group of Japan. These guidelines consist of 1 treatment algorithm, 5 background statement…
View article: A patient with an intraductal papillary mucinous carcinoma with obstructive jaundice caused by a pancreato-biliary fistula
A patient with an intraductal papillary mucinous carcinoma with obstructive jaundice caused by a pancreato-biliary fistula Open
膵管内乳頭粘液性腫瘍(IPMN)は胆管や十二指腸など他臓器に穿破することが知られており,胆管へ穿破した場合,多くが閉塞性黄疸を来す.今回,我々は内視鏡的経鼻胆道ドレナージ(ENBD)を施行し,定期的なチューブ洗浄で良好な減黄後に根治手術をした症例を経験したので報告する.症例は84歳男性,繰り返す発熱を主訴に近医を受診した.精査の結果,IPMNの胆管穿破による閉塞性黄疸と診断された.内視鏡的胆管プラスチックステントを留置するも減黄不良で全身状態悪化のため,当院へ紹介入院となっ…
View article: Automated recognition of objects and types of forceps in surgical images using deep learning
Automated recognition of objects and types of forceps in surgical images using deep learning Open
Analysis of operative data with convolutional neural networks (CNNs) is expected to improve the knowledge and professional skills of surgeons. Identification of objects in videos recorded during surgery can be used for surgical skill asses…
View article: Laparoscopic appendectomy for appendiceal intussusception assisted by colonoscopy: A case report
Laparoscopic appendectomy for appendiceal intussusception assisted by colonoscopy: A case report Open
Simultaneous performance of laparoscopy and intraoperative colonoscopy is feasible and, from an oncological viewpoint, may be preferable when the cause of appendiceal intussusception is unknown or malignancy is not suspected.
View article: Evaluation of Early Prognostic Factors in Patients With Pancreatic Ductal Adenocarcinoma Receiving Gemcitabine Together With Nab-paclitaxel
Evaluation of Early Prognostic Factors in Patients With Pancreatic Ductal Adenocarcinoma Receiving Gemcitabine Together With Nab-paclitaxel Open
Background: Gemcitabine together with nab-paclitaxel (GnP) has been shown to improve outcomes in patients with pancreatic ductal adenocarcinoma (PDAC). However, the predictive markers for treatment effects remain unclear. This study aimed …
View article: A Case of Postoperative Recurrence of Primary Malignant Melanoma of the Esophagus in the Liver with Complete Response with Nivolumab Therapy
A Case of Postoperative Recurrence of Primary Malignant Melanoma of the Esophagus in the Liver with Complete Response with Nivolumab Therapy Open
食道原発悪性黒色腫は悪性度が高く予後不良な疾患とされてきた．しかし，近年，抗PD-1抗体を初めとした免疫療法が適応となり，その使用経験が報告されてきている．症例は75歳の男性で，胸部下部食道に生じた悪性黒色腫に対して食道亜全摘術を施行した．病理組織学的所見はpT1b（SM1）N1M0 pStage IIであった．補助療法なしで経過観察中，術後14か月目のCTで肝転移再発を認めた．ニボルマブ療法を施行したところ腫瘍の縮小を認め，18サイクル投与した時点で画像上完全奏効（com…
View article: Lateral pelvic lymph nodes for rectal cancer: A review of diagnosis and management
Lateral pelvic lymph nodes for rectal cancer: A review of diagnosis and management Open
The current status and future prospects for diagnosis and treatment of lateral pelvic lymph node (LPLN) metastasis of rectal cancer are described in this review. Magnetic resonance imaging (MRI) is recommended for the diagnosis of LPLN met…