Explanipedia

Salvage resection after immunotherapy for giant undifferentiated pleomorphic sarcoma of the chest wall Open

Akifumi Nakamura, Ayumi Kuroda, Masaki Hashimoto, Nobuyuki Kondo, Takashi Yamasaki , et al. · 2025

We present a rare case of primary undifferentiated pleomorphic sarcoma (UPS) of the chest wall in a 45-year-old male, initially diagnosed as sarcomatoid pleural mesothelioma via computed tomography (CT)-guided biopsy. CT revealed a large t…

Postoperative Pain Reduction and Clinical Value of Uniportal Video-Assisted Thoracic Surgery: A Secondary Analysis of the J-RATSIG 01 Study Open

Takuya Watanabe, Masayuki Tanahashi, Masato Chiba, Kumiko Hashimoto, Noriaki Sakakura , et al. · 2025

Postoperative Pain Reduction and Clinical Value of Uniportal Video-Assisted Thoracic Surgery: A Secondary Analysis of the J-RATSIG 01 Study Open

Takuya Watanabe, Masayuki Tanahashi, Masato Chiba, Kumiko Hashimoto, Noriaki Sakakura , et al. · 2025

U-VATS significantly reduced postoperative pain and was associated with shorter operation times, chest tube duration, and hospitalization than M-VATS.

A case of post-irradiation pleural mesothelioma Open

Yuri Murakami-Mizoguchi, Masaki Hashimoto, Toru Nakamichi, Akifumi Nakamura, Nobuyuki Kondo , et al. · 2025

Postoperative Analgesia and Length of Hospital Stay After Surgery for Malignant Pleural Mesothelioma: A Retrospective Observational Study Open

Mayuu Kobata, Kenta Takeda, Makoto Taguchi, Hiroai Okutani, Takeshi Ide , et al. · 2024

Background: Pleurectomy/decortication (P/D), a surgical procedure for malignant pleural mesothelioma (MPM), is a highly invasive surgery requiring prolonged hospitalization. Previous studies have reported that postoperative analgesia using…

Definitive Diagnosis of Pleural Mesothelioma by Pleural Effusion Cytology: The MesoCyto Study Open

Masaki Hashimoto, Toshiyuki Minami, Ryuichi Waseda, Masaru Takenaka, Keigo Uchimura , et al. · 2024

Objective: We evaluated the possibility of diagnosing pleural mesothelioma (PM) through pleural effusion cytology in a multicentric prospective clinical trial (MesoCyto study). Methods: We included patients with pleural effusion and suspec…

Clinical characteristics of long-term survivors of pleural mesothelioma Open

Masaki Hashimoto, A. Nakamura, Toru Nakamichi, Ayumi Kuroda, Kyoshiro Takegahara , et al. · 2024

Objective To identify the clinical characteristics of long-term survivors (> 5 years) with pleural mesothelioma (PM) who had previously undergone curative-intent surgery.Methods A total of 121 patients with PM undergone curative-intent sur…

Comparison of FDG-PET/CT and CT for evaluation of tumor response to nivolumab plus ipilimumab combination therapy and prognosis prediction in patients with unresectable malignant pleural mesothelioma Open

Kazuhiro Kitajima, Kozo Kuribayashi, Toshiyuki Minami, Hiroyuki Yokoyama, Akifumi Nakamura , et al. · 2024

For unresectable MPM patient examinations, FDG-PET and CT provide accurate findings for evaluating tumor response and also prognosis prediction following first-line nivolumab plus ipilimumab immunotherapy (approximately three cycles).

Investigation of the appropriate viscosity of fibrinogen in repairing pleural defects using ventilation and anchoring in an ex vivo pig model Open

Akihiro Fukuda, Masaki Hashimoto, Y. Takegawa, Nobuyuki Kondo, Seiki Hasegawa · 2024

Anomalous systemic arterial supply to normal basal segments of lung with anomalous V6 Open

Akifumi Nakamura, Kyoshiro Takegahara, Toru Nakamichi, Masaki Hashimoto, Nobuyuki Kondo , et al. · 2024

症例は55歳男性．血痰，左胸背部痛精査の胸部X線検査で異常影を認め当院紹介受診となった．胸部造影CTで下行大動脈から左肺底区に流入する異常血管を認め肺底動脈大動脈起始症と診断し，手術の方針となった．手術は左肺底区域切除を企図して開始した．下行大動脈からの異常血管，A8，底区気管支を切離した．続けて下肺静脈を剥離したところ，下肺静脈から直接分岐するV6を認めずすべて底区側から下肺静脈へ還流していた．S6からはsuperior basal veinの末梢から下肺静脈に還流する枝…

Investigation of the appropriate viscosity of fibrinogen in repairing pleural defects using ventilation and anchoring in an ex vivo pig model Open

Akihiro Fukuda, Masaki Hashimoto, Y. Takegawa, Nobuyuki Kondo, Seiki Hasegawa · 2023

Objective Our previous study revealed that the viscosity of fibrinogen could influence the effectiveness of ventilation and anchoring (V/A) methods for controlling air leakages. Here, we examined the association between the viscosity of fi…

Presurgical immune-oncology/tyrosine kinase inhibitor combination therapy for renal cell carcinoma with a vena cava tumor thrombus: a single-institution case series Open

Fumihiko Urabe, Kosuke Iwatani, Masaki Hashimoto, Hirotaka Suzuki, Keiichiro Miyajima , et al. · 2023

Presurgical therapy combined with immunotherapy and tyrosine kinase inhibitors warrants consideration. Nevertheless, surgeons should be mindful of the difficulties that may arise beyond the clinical stage.

Prognostic role of preoperative fluorine-18 fluorodeoxyglucose-positron emission tomography/computed tomography with an image-based harmonization technique: A multicenter retrospective study Open

Akira Hamada, Kazuhiro Kitajima, Kenichi Suda, T. Koga, Junichi Soh , et al. · 2023

Long-term outcomes and risk factors of residual thoracic spaces after pleurectomy/decortication for mesothelioma Open

Akifumi Nakamura, Masaki Hashimoto, Nobuyuki Kondo, Seiji Matsumoto, Toru Nakamichi , et al. · 2022

OBJECTIVES The residual thoracic spaces (RTS) after pleurectomy/decortication (P/D) remain unexplored to date. Hence, this study aims to examine the details and risk factors of RTS during the 3 post-P/D months. METHODS We retrospectively e…

Incidence and Risk Factors of Chest Wall Metastasis at Biopsy Sites in Patients with Malignant Pleural Mesothelioma Open

Masaki Hashimoto, Michiko Yuki, Kazuhiro Kitajima, Akihiro Fukuda, Toru Nakamichi , et al. · 2022

To investigate the incidence and risk factors of chest wall metastasis (CWM) at biopsy sites in patients with malignant pleural mesothelioma (MPM). This retrospective cohort study was conducted in 262 consecutive MPM patients who underwent…

Proposal for a new local recurrence score in patients with recurrent malignant pleural mesothelioma Open

Olivia Lauk, Thomas Neuer, Bianca Battilana, İlhan İnci, Katarzyna Furrer , et al. · 2022

LRS might be a useful prognostic tool in MPM patients with LR after multimodality therapy to guide second line treatment allocation.

Circulating tumor cell methylation profiles reveal the classification and evolution of non-small cell lung cancer Open

Jiahao Jiang, Jian Gao, Chang‐Yue Chen, Yong-Qiang Ao, Jing Li , et al. · 2022

Our findings provide insights into the potential use of CTCs in the pathological classification of NSCLC patients. Our findings also show how CTC primary tumor inheritance and CTC evolution affect metastasis and immune escape.

Incidence and Risk Factors of Chest Wall Metastasis at Biopsy Sites in Patients with Malignant Pleural Mesothelioma Open

Masaki Hashimoto, Michiko Yuki, Kazuhiro Kitajima, Akihiro Fukuda, Toru Nakamichi , et al. · 2022

Deep learning with deep convolutional neural network using FDG-PET/CT for malignant pleural mesothelioma diagnosis Open

Kazuhiro Kitajima, Hidetoshi Matsuo, Atsushi K. Kono, Kozo Kuribayashi, Takashi Kijima , et al. · 2021

Deep learning with 3D DCNN in combination with FDG-PET/CT imaging results as well as clinical features comprise a novel potential tool shows flexibility for differential diagnosis of MPM.

Quality of life and lung function after pleurectomy/decortication for malignant pleural mesothelioma Open

Toru Nakamichi, Masaki Hashimoto, Akifumi Nakamura, Ayumi Kuroda, Takashi Tanaka , et al. · 2021

OBJECTIVES Impact of pleurectomy/decortication (P/D) on quality of life (QOL) is not widely reported. We investigated QOL and lung function after P/D. METHODS A single-centre, retrospective cohort study was performed among patients who und…

Usefulness of Quantitative Bone Single-Photon Emission Computed Tomography/Computed Tomography for Evaluating the Treatment Response of Bone Metastasis in a Lung Cancer Patient Open

Kazuhiro Kitajima, Tatsuya Tsuchitani, Yoshiyuki Takahashi, Toshiyuki Minami, Takashi Yokoi , et al. · 2021

We report a case of bone metastasis arising from lung cancer, including quantitative values obtained with bone single-photon emission computed tomography/computed tomography (SPECT/CT), which were useful to evaluate the treatment response.…

Response to Immune Checkpoint Inhibitor Therapy in Patients with Unresectable Recurrent Malignant Pleural Mesothelioma Shown by FDG-PET and CT Open

Kazuhiro Kitajima, Mitsunari Maruyama, Hiroyuki Yokoyama, Toshiyuki Minami, Takashi Yokoi , et al. · 2021

Background: To compare three FDG-PET criteria (EORTC, PERCIST, imPERCIST) with CT criteria (combined modified RECIST and RECIST 1.1) for response evaluation and prognosis prediction in patients with recurrent MPM treated with ICI monothera…

Fracture of a Temporary Inferior Vena Cava Filter Open

Risa Kishikawa, Takahiro Tanaka, Masaki Hashimoto, Kei Honda, Yasutoshi Omori , et al. · 2021

Anticoagulation is recommended for the treatment of pulmonary embolism (PE) and deep vein thrombosis (DVT). In some cases, an inferior vena cava (IVC) filter is used to prevent PE. We report the case of a 70-year-old woman who developed no…

Relationship Between Physical Function and Health Utility in Patients Undergoing Surgical Treatment for Malignant Pleural Mesothelioma Open

Takashi Tanaka, Shinichiro Morishita, Masaki Hashimoto, Toru Nakamichi, Yuki Uchiyama , et al. · 2021

Purpose: Health utility, which is a measure of patient-reported outcome (PRO), has recently been used in health-related quality of life for patients with various cancers. However, the relationship between health utility and the physical fu…

A Surgical Case of Pancreatic Metastasis from Lung Cancer Open

Kazuhiro Suzumura, Yasukane Asano, Hisashi Kosaka, Shingo Kanemura, Hitomi Kamiya , et al. · 2021

Introduction Most patients with pancreatic metastasis from lung cancer are not candidates for surgical treatment because they have widespread systemic disease at the time of diagnosis. But it was reported that some patients with long-term …

A Retrospective Single-Institutional Analysis of the Usefulness of Pleural Effusion-Cell Block for Diagnosing Malignant Pleural Mesothelioma Open

Masaki Hashimoto, Michiko Yuki, Toru Nakamichi, Akifumi Nakamura, Ayumi Kuroda , et al. · 2020

目的．悪性胸膜中皮腫（MPM）の胸水細胞診にセルブロック（CB）が行われるようになってきたが，その有用性は十分に検証されていない．方法．2018年1月から同年12月の間にMPMを疑い全身麻酔下胸膜生検が施行された44例のうち，生検前にCBを併用した胸水細胞診が行われた25例を対象とし，胸膜生検の診断結果とCBを併用した胸水細胞診の判定結果を後ろ向きに比較した．結果．25例中，22例は胸膜生検でMPMと診断され，3例で悪性所見は認めなかった．MPMと診断された22例のうち18…

Three tumor markers for improved efficacy in the management of patients with malignant pleural mesothelioma Open

Akifumi Nakamura, Teruhisa Takuwa, Masaki Hashimoto, Ayumi Kuroda, Toru Nakamichi , et al. · 2020

The positive rates of SMRP, Cyfra21-1, and TPA in recurrence-free patients were extremely low, with high specificity. Preoperative levels of SMRP, Cyfra21-1, and TPA, which identified patients with a high risk for recurrence, could improve…

Development of an effective method utilizing fibrin glue to repair pleural defects in an ex-vivo pig model Open

Nobuyuki Kondo, Y. Takegawa, Masaki Hashimoto, Seiji Matsumoto, Shiro Oka , et al. · 2020

Background The present study aimed to use an ex-vivo model to investigate whether a new method involving the use of fibrin glue and a polyglycolic acid (PGA) sheet under ventilation enhances the sealing effect after repair of the pleural d…

Initial evaluation of nivolumab in patients with post-operative recurrence of malignant pleural mesothelioma Open

Akifumi Nakamura, Nobuyuki Kondo, Toru Nakamichi, Ayumi Kuroda, Masaki Hashimoto , et al. · 2020

Background Limited options exist for treating post-recurrence patients with malignant pleural mesothelioma (MPM). This study aimed to evaluate the efficacy and feasibility of nivolumab in patients with post-operative recurrence of MPM in a…

Non-incisional pleurectomy/decortication Open

Seiki Hasegawa, Masaki Hashimoto, Nobuyuki Kondo, Yoshihiro Miyamoto · 2020

One of the potential disadvantages of conventional pleurectomy/decortication for malignant pleural mesothelioma is the need for opening the pleural sac, which might worsen survival. In this study, we have introduced non-incisional pleurect…

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