Masaki Shimizu
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View article: EXPANDING IRRADIATION FIELD AT ULTRA-HIGH DOSE RATE ELIMINATES SPARING EFFECT
EXPANDING IRRADIATION FIELD AT ULTRA-HIGH DOSE RATE ELIMINATES SPARING EFFECT Open
View article: Cotton-Wool Appearance of Muscular Polyarteritis Nodosa on Contrast Magnetic Resonance Imaging
Cotton-Wool Appearance of Muscular Polyarteritis Nodosa on Contrast Magnetic Resonance Imaging Open
View article: Diverse Joint Manifestations in Anti‐ <scp>MDA5</scp> Antibody‐Positive Juvenile Dermatomyositis: A Unique Case Report
Diverse Joint Manifestations in Anti‐ <span>MDA5</span> Antibody‐Positive Juvenile Dermatomyositis: A Unique Case Report Open
View article: Macrophage activation syndrome associated with multi-system inflammatory syndrome in children: a case report and cytokine profile
Macrophage activation syndrome associated with multi-system inflammatory syndrome in children: a case report and cytokine profile Open
Macrophage activation syndrome (MAS) is a potentially life-threatening complication requiring early diagnosis and prompt treatment in rheumatic diseases such as systemic juvenile idiopathic arthritis (sJIA). Recently, multisystem inflammat…
View article: Dynamics of the cytokine profiles in Rasmussen's encephalitis: A case report
Dynamics of the cytokine profiles in Rasmussen's encephalitis: A case report Open
View article: Development of mild encephalitis with a reversible splenial lesion prior to the diagnosis of Kawasaki disease: a pediatric case report
Development of mild encephalitis with a reversible splenial lesion prior to the diagnosis of Kawasaki disease: a pediatric case report Open
Kawasaki disease (KD) rarely causes neurological complications. KD is diagnosed based on symptoms alone and can be very difficult to diagnose if other symptoms appear in febrile children before the main symptoms of KD. A 5-year-old boy wit…
View article: Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome
Serum Cytokine Profiling Differentiates Underlying Diseases in Cytokine Storm Syndrome Open
Objective Cytokine storm syndrome (CSS), commonly associated with hemophagocytic lymphohistiocytosis (HLH), is a fatal hyperinflammatory syndrome. Differentiating the underlying diseases responsible for CSS is essential for timely therapeu…
View article: A case of early diagnosis of congenital multisystem langerhans cell histiocytosis with thymic involvement triggered by newborn screening
A case of early diagnosis of congenital multisystem langerhans cell histiocytosis with thymic involvement triggered by newborn screening Open
T-cell receptor excision circle (TREC)-based newborn screening is a method for the early detection of severe combined immunodeficiency (SCID); however, undetectable TREC level results have also been reported in conditions other than SCID. …
View article: Overlapping Aicardi–Goutières and Singleton–Merten syndromes with a heterozygous gain-of-function mutation in <i>IFIH1</i> mimicking juvenile idiopathic arthritis
Overlapping Aicardi–Goutières and Singleton–Merten syndromes with a heterozygous gain-of-function mutation in <i>IFIH1</i> mimicking juvenile idiopathic arthritis Open
Aicardi-Goutières syndrome (AGS) and Singleton-Merten syndrome (SMS) are associated with heterozygous gain-of-function mutations in the interferon induced with helicase C domain 1 (IFIH1) gene. Recent reports describe patients exhibiting o…
View article: The Appropriate Conditions for the Cell Sparing (FLASH) Effect Exist in Ultra-high Dose Rate Carbon Ion Irradiation
The Appropriate Conditions for the Cell Sparing (FLASH) Effect Exist in Ultra-high Dose Rate Carbon Ion Irradiation Open
Carbon ion uHDR irradiation induces a cell-sparing effect under normoxic conditions, which is influenced by LET and oxygen concentration. These findings provide essential insights into the mechanisms underlying the FLASH effect and pave th…
View article: Atlantoaxial arthritis is more common in polyarticular <scp>JIA</scp> as compared to systemic onset <scp>JIA</scp>—Retrospective study
Atlantoaxial arthritis is more common in polyarticular <span>JIA</span> as compared to systemic onset <span>JIA</span>—Retrospective study Open
View article: Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project
Current treatment in macrophage activation syndrome worldwide: a systematic literature review to inform the METAPHOR project Open
Objective To assess current treatment in macrophage activation syndrome (MAS) worldwide and to highlight any areas of major heterogeneity of practice. Methods A systematic literature search was performed in both EMBASE and PubMed databases…
View article: Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams
Development and characterization of a dedicated dose monitor for ultrahigh-dose-rate scanned carbon-ion beams Open
View article: Case Report: A neonatal case of cryopyrin-associated periodic syndrome with severe funisitis and neonatal asphyxia
Case Report: A neonatal case of cryopyrin-associated periodic syndrome with severe funisitis and neonatal asphyxia Open
Cryopyrin-associated periodic syndrome (CAPS) is a genetic disorder and autoinflammatory disease characterized by chronic inflammation throughout the body. The most severe form of CAPS, Chronic Infantile Neurologic Cutaneous, and Articular…
View article: Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature
Successful treatment with tofacitinib for anti-melanoma differentiation-associated gene 5 antibody-positive juvenile dermatomyositis: case reports and review of the literature Open
Although the clinical efficacy of tofacitinib has been reported in adult patients with anti-melanoma differentiation-associated gene 5 (MDA5) antibody-positive (Ab+) dermatomyositis, data on its use in refractory juvenile dermatomyositis (…
View article: Possible correlation between serum interleukin-8 levels and the activity of myositis in anti-NXP2 antibody-positive dermatomyositis
Possible correlation between serum interleukin-8 levels and the activity of myositis in anti-NXP2 antibody-positive dermatomyositis Open
Anti-nuclear matrix protein 2 (NXP2) antibody-positive dermatomyositis (DM) is characterized by extensive and severe myositis. In this study, we evaluated which cytokines/chemokines involved with the activity of the myositis. We performed …
View article: Correction: Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1–14 Years with Chronic Gastric Acid-Related Disease
Correction: Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1–14 Years with Chronic Gastric Acid-Related Disease Open
[This corrects the article on p. 274 in vol. 27, PMID: 39319279.].
View article: Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1–14 Years with Chronic Gastric Acid-Related Disease
Efficacy and Safety of Long-Term Administration of Esomeprazole in Japanese Pediatric Patients Aged 1–14 Years with Chronic Gastric Acid-Related Disease Open
Long-term use of 10- or 20-mg, once-daily esomeprazole demonstrated a favorable benefit-risk balance in preventing RE and suppressing recurrence of GU and/or DU secondary to NSAID or LDA therapy in Japanese pediatric patients. No new safet…
View article: Investigation of Ionization Chamber Characteristics for Ultrahigh-dose-rate Scanned Carbon-ion Beams
Investigation of Ionization Chamber Characteristics for Ultrahigh-dose-rate Scanned Carbon-ion Beams Open
All ionization chambers can be used for measuring the relative dose, and absolute dose can be conveniently measured using the AMC with an uHDR carbon-ion scanned beam.
View article: Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial
Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial Open
View article: Adenosine monophosphate deaminase in the endoplasmic reticulum–mitochondria interface promotes mitochondrial Ca<sup>2+</sup> overload in type 2 diabetes rat hearts
Adenosine monophosphate deaminase in the endoplasmic reticulum–mitochondria interface promotes mitochondrial Ca<sup>2+</sup> overload in type 2 diabetes rat hearts Open
Aims/Introduction We previously showed that upregulation of myocardial adenosine monophosphate deaminase (AMPD) is associated with pressure overload‐induced diastolic dysfunction in type 2 diabetes hearts. Here, we examined involvement of …
View article: Downregulation of extramitochondrial <scp>BCKDH</scp> and its uncoupling from <scp>AMP</scp> deaminase in type 2 diabetic <scp>OLETF</scp> rat hearts
Downregulation of extramitochondrial <span>BCKDH</span> and its uncoupling from <span>AMP</span> deaminase in type 2 diabetic <span>OLETF</span> rat hearts Open
Systemic branched‐chain amino acid (BCAA) metabolism is dysregulated in cardiometabolic diseases. We previously demonstrated that upregulated AMP deaminase 3 (AMPD3) impairs cardiac energetics in a rat model of obese type 2 diabetes, Otsuk…
View article: Relationship of cerebral blood volume with arterial and venous flow velocities in extremely low-birth- weight infants
Relationship of cerebral blood volume with arterial and venous flow velocities in extremely low-birth- weight infants Open
Purpose: Unstable cerebral blood flow is theorised to contribute to the occurrence of intraventricular haemorrhage (IVH) in extremely low-birth-weight infants (ELBWIs), which can be caused by increased arterial flow, increased venous press…
View article: Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function
Janus kinase inhibitors ameliorate clinical symptoms in patients with STAT3 gain-of-function Open
Summary Germline gain-of-function (GOF) variants in the signal transducer and activator of transcription 3 (STAT3) gene is an inborn error of immunity presenting with autoimmunity and lymphoproliferation. Symptoms can vary widely, and no e…
View article: Case report: Optimized ruxolitinib-based therapy in an infant with familial hemophagocytic lymphohistiocytosis type 3
Case report: Optimized ruxolitinib-based therapy in an infant with familial hemophagocytic lymphohistiocytosis type 3 Open
Familial hemophagocytic lymphohistiocytosis (FHL) is a rare and fatal autosomal recessive immune disorder characterized by uncontrolled activation of T and NK cells, macrophages, and overproduction of inflammatory cytokines. Early hematopo…
View article: Long-term efficacy and safety of canakinumab in the treatment of systemic juvenile idiopathic arthritis in Japanese patients: Results from an open-label Phase III study
Long-term efficacy and safety of canakinumab in the treatment of systemic juvenile idiopathic arthritis in Japanese patients: Results from an open-label Phase III study Open
Objectives The objective of the study was to report the efficacy and safety of canakinumab treatment in Japanese patients with systemic juvenile idiopathic arthritis (sJIA) over a 48-week study period. Methods Patients were administered ca…
View article: Clinical Course and Cytokine Profile of Systemic Juvenile Idiopathic Arthritis in a Patient with Trisomy 21
Clinical Course and Cytokine Profile of Systemic Juvenile Idiopathic Arthritis in a Patient with Trisomy 21 Open
Trisomy 21 (Down syndrome) is sometimes complicated by congenital heart disease; however, comorbid type I diabetes mellitus and diseases involving autoantibodies, such as Hashimoto disease and Graves disease, are not uncommon. Autoinflamma…
View article: Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience
Assessment of type I interferon signatures in undifferentiated inflammatory diseases: A Japanese multicenter experience Open
Purpose Upregulation of type I interferon (IFN) signaling has been increasingly detected in inflammatory diseases. Recently, upregulation of the IFN signature has been suggested as a potential biomarker of IFN-driven inflammatory diseases.…
View article: Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases
Pathogenic roles and diagnostic utility of interleukin-18 in autoinflammatory diseases Open
Interleukin (IL)-18 is a pleiotropic, pro-inflammatory cytokine involved in the regulation of innate and adaptive immune responses. IL-18 has attracted increasing attention as a key mediator in autoinflammatory diseases associated with the…
View article: A method to soothe and promote sleep in crying infants utilizing the transport response
A method to soothe and promote sleep in crying infants utilizing the transport response Open