Masamichi Ikawa
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View article: Potential strategies for combination therapy involving medicines with differential signal transduction regulation effects and the mechanism of action of minocycline in septic neuroinflammation
Potential strategies for combination therapy involving medicines with differential signal transduction regulation effects and the mechanism of action of minocycline in septic neuroinflammation Open
View article: Intramuscular hemorrhage during rehabilitation in a post-stroke patient with vascular Ehlers-Danlos syndrome: a case report and review of spasticity-related muscle injury
Intramuscular hemorrhage during rehabilitation in a post-stroke patient with vascular Ehlers-Danlos syndrome: a case report and review of spasticity-related muscle injury Open
We present the first documented case of vascular Ehlers-Danlos syndrome (vEDS) associated with muscle injury in a spastic muscle following a stroke, which occurred during physical therapy. The patient was a 46-year-old male with a family h…
View article: Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI
Association of vitamin B12 deficiency in a dementia cohort with hippocampal atrophy on MRI Open
Vitamin B12 deficiency was associated with hippocampal atrophy detected by VSRAD analysis. Therefore, early vitamin B12 supplementation should be considered in patients with deficiencies to reduce dementia risk.
View article: Effect of Remote Exercise Interventions on the Risk of Incident Functional Disability Certification among Community-Dwelling Older Adults: Before-and-After Study
Effect of Remote Exercise Interventions on the Risk of Incident Functional Disability Certification among Community-Dwelling Older Adults: Before-and-After Study Open
View article: Reduced phase angle as a potential indicator of mild cognitive impairment
Reduced phase angle as a potential indicator of mild cognitive impairment Open
In this study, we investigated the relationship between phase angle (PhA), measured using bioelectrical impedance analysis (BIA), and mild cognitive impairment (MCI). A cross-sectional analysis was conducted on 290 community residents (83.…
View article: Syk inhibitors reduce tau protein phosphorylation and oligomerization
Syk inhibitors reduce tau protein phosphorylation and oligomerization Open
Spleen tyrosine kinase (Syk), a non-receptor-type tyrosine kinase, has a wide range of physiological functions. A possible role of Syk in Alzheimer's disease (AD) has been proposed. We evaluated the localization of Syk in the brains of pat…
View article: Individualized Nutritional Management Using Dishcook Improves Nutrition Status Markers in Patients with Intellectual Disability
Individualized Nutritional Management Using Dishcook Improves Nutrition Status Markers in Patients with Intellectual Disability Open
Dishcook is a new cooking system that allows individual cooking using a dedicated induction heater. This study investigated whether Dishcook use affects the nutritional value of individuals with intellectual disabilities. This study was co…
View article: PET/MRI multimodality imaging to evaluate changes in glymphatic system function and biomarkers of Alzheimer’s disease
PET/MRI multimodality imaging to evaluate changes in glymphatic system function and biomarkers of Alzheimer’s disease Open
View article: Expanding clinical spectrum from Hashimoto's encephalopathy to <scp>anti‐NAE</scp> antibody‐associated disorders (<scp>NAEAD</scp>)
Expanding clinical spectrum from Hashimoto's encephalopathy to <span>anti‐NAE</span> antibody‐associated disorders (<span>NAEAD</span>) Open
Using proteomic analysis, we identified anti‐NAE antibodies (autoantibodies against N H 2 ‐terminal of a lpha‐ e nolase) as a diagnostic marker for Hashimoto's encephalopathy (HE). As cases of HE with serum anti‐NAE antibodies accumulated,…
View article: Anti-Kv1.4 Antibody-positive Nivolumab-induced Myasthenia Gravis and Myositis Presenting with Bilateral Ptosis and Demonstrating Different Pathophysiologies
Anti-Kv1.4 Antibody-positive Nivolumab-induced Myasthenia Gravis and Myositis Presenting with Bilateral Ptosis and Demonstrating Different Pathophysiologies Open
Nivolumab blocks inhibitors of T-cell activation and restores antitumor immunity but promotes T-cell activity in host tissues by blocking inhibition of the T-cell function, resulting in immune-related adverse effects. We herein report an 8…
View article: Magnetic resonance imaging arterial spin labeling hypoperfusion with diffusion-weighted image hyperintensity is useful for diagnostic imaging of Creutzfeldt–Jakob disease
Magnetic resonance imaging arterial spin labeling hypoperfusion with diffusion-weighted image hyperintensity is useful for diagnostic imaging of Creutzfeldt–Jakob disease Open
Background and objectives Magnetic resonance imaging with arterial spin labeling (ASL) perfusion imaging is a noninvasive method for quantifying cerebral blood flow (CBF). We aimed to evaluate the clinical utility of ASL perfusion imaging …
View article: Ten-year follow up of incidental spontaneous extracranial internal carotid artery dissection in a Japanese asymptomatic older man: A case report
Ten-year follow up of incidental spontaneous extracranial internal carotid artery dissection in a Japanese asymptomatic older man: A case report Open
This report presents a unique finding of an incidental right internal carotid artery dissection in an asymptomatic 69-year-old man. The report highlights the possible trigger and long-term outcomes of this condition. The patient had partic…
View article: Low-frequency maternal novel MYH7 mosaicism mutation in recurrent fetal-onset severe left ventricular noncompaction: a case report
Low-frequency maternal novel MYH7 mosaicism mutation in recurrent fetal-onset severe left ventricular noncompaction: a case report Open
Background Left ventricular noncompaction (LVNC) is a rare inherited cardiomyopathy with a broad phenotypic spectrum. The genotype-phenotype correlations in fetal-onset LVNC have not yet been fully elucidated. In this report, we present th…
View article: Effectiveness of a self-reporting yes/no survey for dementia screening—trial in Fukui, Japan
Effectiveness of a self-reporting yes/no survey for dementia screening—trial in Fukui, Japan Open
Background: Early intervention for dementia patients is extremely important for the prevention of dementia. However, so far, it is not clear as to what kind of screening will be useful for the early detection of dementia. Objective: We aim…
View article: Cerebral Oxidative Stress in Early Alzheimer’s Disease Evaluated by 64Cu-ATSM PET/MRI: A Preliminary Study
Cerebral Oxidative Stress in Early Alzheimer’s Disease Evaluated by 64Cu-ATSM PET/MRI: A Preliminary Study Open
Oxidative stress imaging using diacetyl-bis (N4-methylthiosemicarbazone) (Cu-ATSM) was applied to the evaluation of patients with early Alzheimer’s disease (eAD). Ten eAD patients (72 ± 9 years) and 10 age-matched healthy controls (HCs) (7…
View article: Persistent Severe Cerebral Edema with Neutrophil Infiltration Following<i> Listeria</i> Meningitis
Persistent Severe Cerebral Edema with Neutrophil Infiltration Following<i> Listeria</i> Meningitis Open
A 51-year-old man was admitted to the hospital with a diagnosis of Listeria monocytogenes meningitis. Diffuse cerebral edema appeared after improvement of meningitis with appropriate treatment and worsened for two months. Due to brain hern…
View article: Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment
Influences of Vitamin B12 Supplementation on Cognition and Homocysteine in Patients with Vitamin B12 Deficiency and Cognitive Impairment Open
Vitamin B12 deficiency is associated with cognitive impairment, hyperhomocysteinemia, and hippocampal atrophy. However, the recovery of cognition with vitamin B12 supplementation remains controversial. Of the 1716 patients who visited our …
View article: Autoimmune basal ganglia encephalitis associated with anti-recoverin antibodies: A case report
Autoimmune basal ganglia encephalitis associated with anti-recoverin antibodies: A case report Open
Autoimmune basal ganglia encephalitis causes neurological symptoms such as parkinsonism associated with basal ganglia lesions. Here, we report a case of autoimmune basal ganglia encephalitis without retinal lesions or malignancy harboring …
View article: Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein
Clioquinol Decreases Levels of Phosphorylated, Truncated, and Oligomerized Tau Protein Open
The neuropathological hallmarks of Alzheimer’s disease (AD) are senile plaques (SPs), which are composed of amyloid β protein (Aβ), and neurofibrillary tangles (NFTs), which consist of highly phosphorylated tau protein. As bio-metal imbala…
View article: Autophagy and Tau Protein
Autophagy and Tau Protein Open
Neurofibrillary tangles, which consist of highly phosphorylated tau protein, and senile plaques (SPs) are pathological hallmarks of Alzheimer’s disease (AD). In swollen axons, many autophagic vacuoles are observed around SP in the AD brain…
View article: Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies
Progressive Encephalomyelitis with Rigidity and Myoclonus (PERM)-like Symptoms Associated with Anti-ganglionic Acetylcholine Receptor Antibodies Open
This report describes a 59-year-old woman who presented with progressive encephalomyelitis with rigidity and myoclonus (PERM)-like symptoms and severe dysautonomia, including orthostatic hypotension, sinus bradycardia, dysuria, and prolong…
View article: Quantitative Evaluation of 18F-Flutemetamol PET in Patients With Cognitive Impairment and Suspected Alzheimer's Disease: A Multicenter Study
Quantitative Evaluation of 18F-Flutemetamol PET in Patients With Cognitive Impairment and Suspected Alzheimer's Disease: A Multicenter Study Open
Background: In clinical practice, equivocal findings are inevitable in visual interpretation of whether amyloid positron emission tomography (PET) is positive or negative. It is therefore necessary to establish a more objective quantitativ…
View article: Clioquinol reduces tau phosphorylation and oligomerization
Clioquinol reduces tau phosphorylation and oligomerization Open
Background The pathological features of AD are neurofibrillary tangles (NFTs) composed of highly phosphorylated tau and senile plaques (SPs) composed of amyloid β protein (Aβ). It was suggested that Cu 2 + induced hyperphosphorylation of t…
View article: Syk inhibitor reduces oligomeric tau associated with GSK3β inactivation and autophagy activation
Syk inhibitor reduces oligomeric tau associated with GSK3β inactivation and autophagy activation Open
Background Neurofibrillary tangle (NFT), composed of highly phosphorylated tau is one of the pathological hallmarks of Alzheimer’s disease (AD). Spleen tyrosine kinase (Syk) is non receptor type tyrosine kinase, and has various physiologic…
View article: Noninvasive Measurement of [11C]PiB Distribution Volume Using Integrated PET/MRI
Noninvasive Measurement of [11C]PiB Distribution Volume Using Integrated PET/MRI Open
A noninvasive image-derived input function (IDIF) method using PET/MRI was applied to quantitative measurements of [11C] Pittsburgh compound-B (PiB) distribution volume (DV) and compared with other metrics. Fifty-three patients suspected o…
View article: Influences of Folate Supplementation on Homocysteine and Cognition in Patients with Folate Deficiency and Cognitive Impairment
Influences of Folate Supplementation on Homocysteine and Cognition in Patients with Folate Deficiency and Cognitive Impairment Open
Although folate deficiency was reported to be associated with hyperhomocysteinemia, influence of folate supplementation on cognition remains controversial. Therefore, we explored the effects of folate supplementation on the cognition and H…
View article: A new diagnostic indication device of a biomarker <scp>growth differentiation factor 15</scp> for mitochondrial diseases: From laboratory to automated inspection
A new diagnostic indication device of a biomarker <span>growth differentiation factor 15</span> for mitochondrial diseases: From laboratory to automated inspection Open
Mitochondrial diseases (MDs) are occasionally difficult to diagnose. Growth differentiation factor 15 (GDF15) has been reported as a biomarker useful for not only diagnosing MDs, but also evaluating disease severity and therapeutic efficac…
View article: Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis
Antibodies to the α3 subunit of the ganglionic-type nicotinic acetylcholine receptors in patients with autoimmune encephalitis Open
Since autonomic dysfunction is closely associated with autoimmune encephalitis (AE), the objective of this study was to determine the autonomic symptoms and the prevalence of anti-α3 subunit of the ganglionic-type nicotinic acetylcholine r…
View article: PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction
PET Imaging for Oxidative Stress in Neurodegenerative Disorders Associated with Mitochondrial Dysfunction Open
Oxidative stress based on mitochondrial dysfunction is assumed to be the principal molecular mechanism for the pathogenesis of many neurodegenerative disorders. However, the effects of oxidative stress on the neurodegeneration process in l…
View article: CPC: An Autopsied Case of Myopathy Presenting with Fever and CK Elevation during Steroid Therapy
CPC: An Autopsied Case of Myopathy Presenting with Fever and CK Elevation during Steroid Therapy Open
本症例は筋炎のステロイド治療中に発熱，CK (creatine kinase) 上昇を認めた1剖検例であるが， 1．CK上昇の原因は筋炎の再燃か別の原因か？ 2．死因は何か？ はじめに 遠藤：壊死性ミオパチーは，筋病理では炎症 性細胞浸潤をほとんど認めず，筋線維の壊死・ 再生を認めることが特徴です 1) ．抗SRP(signal recognition particle)抗体が約 40％，抗HMGCR (3-hydroxy-3-methylglutaryl-coenzyme…