Masato Ono
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View article: Microstructure of Additively Manufactured SUS316L Stainless Steel with SrO Heterogeneous Nucleation Site Particles
Microstructure of Additively Manufactured SUS316L Stainless Steel with SrO Heterogeneous Nucleation Site Particles Open
It is known that the addition of SrO heterogeneous nucleation site particles can refine the microstructure of SUS316L stainless steel additively manufactured (AMed) by powder bed fusion (PBF). In this study, this idea was confirmed by dire…
View article: A fossil bumblebee (Hymenoptera, Apidae, Bombini) from the Middle Pleistocene Shiobara Group in Nasushiobara, Tochigi, Japan
A fossil bumblebee (Hymenoptera, Apidae, Bombini) from the Middle Pleistocene Shiobara Group in Nasushiobara, Tochigi, Japan Open
View article: 5.5 – 00117 HIV-Tocky system in primary CD4+T cells joined with transcriptomic and epigenomic analysis to discover mechanism involves in the establishment of latency during acute infection
5.5 – 00117 HIV-Tocky system in primary CD4+T cells joined with transcriptomic and epigenomic analysis to discover mechanism involves in the establishment of latency during acute infection Open
View article: Cross-mating between the alien bumblebee Bombus terrestris and two native Japanese bumblebees, B. hypocrita sapporensis and B. cryptarum florilegus, in the Nemuro Peninsula, Japan
Cross-mating between the alien bumblebee Bombus terrestris and two native Japanese bumblebees, B. hypocrita sapporensis and B. cryptarum florilegus, in the Nemuro Peninsula, Japan Open
View article: Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice
Protective Effects of Imeglimin and Metformin Combination Therapy on β-Cells in db/db Male Mice Open
Imeglimin and metformin act in metabolic organs, including β-cells, via different mechanisms. In the present study, we investigated the impacts of imeglimin, metformin, or their combination (Imeg + Met) on β-cells, the liver, and adipose t…
View article: CCR7 Mediates Cell Invasion and Migration in Extrahepatic Cholangiocarcinoma by Inducing Epithelial–Mesenchymal Transition
CCR7 Mediates Cell Invasion and Migration in Extrahepatic Cholangiocarcinoma by Inducing Epithelial–Mesenchymal Transition Open
The epithelial–mesenchymal transition (EMT) contributes to the metastatic cascade in various tumors. C-C chemokine receptor 7 (CCR7) interacts with its ligand, chemokine (C-C motif) ligand 19 (CCL19), to promote EMT. However, the associati…
View article: Surface Finishing Dependence of Pumping Performance and Peel Resistance of the Stainless Steel Bellows Deposited with Oxygen-Free Pd/Ti Nonevaporable Getter (NEG)
Surface Finishing Dependence of Pumping Performance and Peel Resistance of the Stainless Steel Bellows Deposited with Oxygen-Free Pd/Ti Nonevaporable Getter (NEG) Open
Nonevaporable getter (NEG) pumps are widely used in ultra-high vacuum (UHV) apparatus to evacuate residual gasses efficiently in UHV of 10–7 Pa or less. NEG pumps can be use in oil-free, noise-free, vibration-free, space-saving, energy-sav…
View article: Positive geographic correlation between soldiers’ weapon size and defensive prowess in a eusocial aphid, Ceratovacuna japonica
Positive geographic correlation between soldiers’ weapon size and defensive prowess in a eusocial aphid, Ceratovacuna japonica Open
View article: Genes associated with hot defensive bee ball in the Japanese honeybee, Apis cerana japonica
Genes associated with hot defensive bee ball in the Japanese honeybee, Apis cerana japonica Open
View article: Diagnosis of Chromosome 15q-Terminal Deletion Syndrome through Elevated Fasting Serum Growth Hormone Levels
Diagnosis of Chromosome 15q-Terminal Deletion Syndrome through Elevated Fasting Serum Growth Hormone Levels Open
Chromosome 15q26-qter deletion syndrome is a rare disease that causes prenatal and postnatal growth retardation, microcephaly, developmental delay, and congenital heart diseases, mainly due to haploinsufficiency of IGF1R. In addition, pati…
View article: The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes
The Feasibility and Applicability of Stem Cell Therapy for the Cure of Type 1 Diabetes Open
Stem cell therapy using islet-like insulin-producing cells derived from human pluripotent stem cells has the potential to allow patients with type 1 diabetes to withdraw from insulin therapy. However, several issues exist regarding the use…
View article: Neural activity mapping of bumble bee (Bombus ignitus) brains during foraging flight using immediate early genes
Neural activity mapping of bumble bee (Bombus ignitus) brains during foraging flight using immediate early genes Open
Honey bees and bumble bees belong to the same family (Apidae) and their workers exhibit a division of labor, but the style of division of labor differs between species. The molecular and neural bases of the species-specific social behavior…
View article: A Case of Early-stage Duodenal Bulb Cancer Treated with Laparoscopic Limited Distal Gastrectomy
A Case of Early-stage Duodenal Bulb Cancer Treated with Laparoscopic Limited Distal Gastrectomy Open
症例は64歳，男性．前医の採血で腫瘍マーカーの上昇を認め，上部消化管内視鏡にて十二指腸球部に隆起性病変を認めた．また，CTで右肺野に約20mm大の結節影を認め，精査目的に当院へ紹介となった．当院で行った上部消化管内視鏡検査で十二指腸病変の生検では腺癌が疑われ，壁深達度はSM相当と診断した．右肺病変は原発性肺癌と診断したが，遠隔転移やリンパ節腫大を認めなかった．呼吸器内科・呼吸器外科と協議の上，十二指腸腫瘍の治療を先行する方針とし，各々の進行度を考慮して，幽門周囲のみの郭清を…
View article: Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma
Prognostic relevance of tertiary lymphoid organs following neoadjuvant chemoradiotherapy in pancreatic ductal adenocarcinoma Open
The efficacy of preoperative neoadjuvant chemoradiotherapy ( NAC ) in cases of pancreatic cancer with extremely poor prognoses has been reported. In this study, we aimed to identify novel biomarkers that reflect prognoses following chemora…
View article: Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair
Somatic role of SYCE2: an insulator that dissociates HP1α from H3K9me3 and potentiates DNA repair Open
The synaptonemal complex is a proteinaceous structure essential for meiotic recombination, and its components have been assumed to play a role exclusively in the germ line. However, SYCE2, a component constituting the synaptonemal complex,…
View article: 5-Aminolevulinic-acid-mediated Photodynamic Diagnosis Enhances the Detection of Peritoneal Metastases in Biliary Tract Cancer in Mice
5-Aminolevulinic-acid-mediated Photodynamic Diagnosis Enhances the Detection of Peritoneal Metastases in Biliary Tract Cancer in Mice Open
5-ALA PDD was useful for diagnosis of biliary tract cancer and detection of small peritoneal metastatic lesions in murine models of biliary cancers. Clinical studies and applications of 5-ALA PDD for biliary tract cancer are expected in th…
View article: Scientific note on interrupted sexual behavior to virgin queens and expression of male courtship-related gene fruitless in a gynandromorph of bumblebee, Bombus ignitus
Scientific note on interrupted sexual behavior to virgin queens and expression of male courtship-related gene fruitless in a gynandromorph of bumblebee, Bombus ignitus Open
View article: Actinomycosis of the Inguinal Region Presenting as an Inguinal Hernia/Recurrent Nodule Secondary to Peritoneal Metastasis after Gastrectomy for Gastric Cancer—A Case Report—
Actinomycosis of the Inguinal Region Presenting as an Inguinal Hernia/Recurrent Nodule Secondary to Peritoneal Metastasis after Gastrectomy for Gastric Cancer—A Case Report— Open
症例は84歳，男性．慢性腎不全，胃癌術後のため当院に通院中．2週前より続く右下腹部の違和感を主訴に受診．右鼠径部に圧痛を伴う可動性のない硬結を認め，鼠径ヘルニア嵌頓を疑った．CTで右鼠径部に腫瘤を認めたが腸管の脱出は明らかではなく，精索水腫を疑い経過観察とした．再診時にも所見に変化はなく，診断と治療目的に局所麻酔下の切除を予定した．鼠径ヘルニア手術に準じて外腹斜筋腱膜を切開すると周囲組織と剥離困難な腫瘤性病変を認め，開放すると少量の白濁液を伴う組織塊を認めた．周囲組織との関…
View article: Molecular targeting of cell-permeable peptide inhibits pancreatic ductal adenocarcinoma cell proliferation
Molecular targeting of cell-permeable peptide inhibits pancreatic ductal adenocarcinoma cell proliferation Open
The cell-permeable peptide DN-C16orf74 has a strong anti-tumor effect against PDAC in vitro and in vivo.
View article: Increased complexity of mushroom body Kenyon cell subtypes in the brain is associated with behavioral evolution in hymenopteran insects
Increased complexity of mushroom body Kenyon cell subtypes in the brain is associated with behavioral evolution in hymenopteran insects Open
In insect brains, the mushroom bodies (MBs) are a higher-order center for sensory integration and memory. Honeybee ( Apis mellifera L.) MBs comprise four Kenyon cell (KC) subtypes: class I large-, middle-, and small-type, and class II KCs,…
View article: Patrolling and scent-marking behavior in Japanese bumblebee Bombus ardens ardens males: alternative mating tactic?
Patrolling and scent-marking behavior in Japanese bumblebee Bombus ardens ardens males: alternative mating tactic? Open
View article: A case of multicentric Castleman's disease mimicking pulmonary malignant tumor
A case of multicentric Castleman's disease mimicking pulmonary malignant tumor Open
症例は68歳，女性．肺腺癌に対し左肺上葉切除を行いその後の画像フォロー中に，右中葉にすりガラス状結節の増大を認めた．陰影は徐々に明瞭化し，中心部の濃度上昇を認めた．他の部位にも，すりガラス状結節の出現・増大を認めた．術前血液生化学所見では，蛋白分画パターンでγ-グロブリン分画が25.6％と異常高値であった．CT画像の経時的な変化から異時性多発肺癌を疑い，前回手術より約5年後に胸腔鏡下中葉切除術を施行した．病理所見では形質細胞とリンパ球の間質への浸潤がみられ，MALTリンパ腫…