Masatoshi Koga
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View article: DWI-Positive Lesions in Acute Intracerebral Hemorrhage and Their Correlation With Small Vessel Disease
DWI-Positive Lesions in Acute Intracerebral Hemorrhage and Their Correlation With Small Vessel Disease Open
DWI-positive lesions are observed before blood pressure lowering, and their frequency increases over time. Their association with SVD markers highlights the role of advanced SVD in lesion formation. These lesions may worsen clinical outcom…
View article: Reversible cerebral vasoconstriction syndrome with delayed vasospasms and subdural hematoma after cardiac transplantation: a case report
Reversible cerebral vasoconstriction syndrome with delayed vasospasms and subdural hematoma after cardiac transplantation: a case report Open
Background Reversible cerebral vasoconstriction syndrome (RCVS) is a rare but severe neurovascular complication following cardiac transplantation. Its diagnosis is often complicated by atypical presentations and by neuroimaging limitations…
View article: Clinical Characteristics in Adult Congenital Heart Disease Patients With Acute Stroke ― A Retrospective Analysis ―
Clinical Characteristics in Adult Congenital Heart Disease Patients With Acute Stroke ― A Retrospective Analysis ― Open
ACHD patients with acute stroke were significantly younger and more frequently developed LVO compared with the general stroke population, with ASD being the most common type of CHD. Despite their favorable short-term prognosis, these chara…
View article: Investigation of thrombectomy technique for M2 occlusion based on the M1–M2 bifurcation angle
Investigation of thrombectomy technique for M2 occlusion based on the M1–M2 bifurcation angle Open
Purpose The efficacy of mechanical thrombectomy (MT) for M2 occlusion remains uncertain, partly due to recanalization challenges owing to anatomical factors and hemorrhagic complications. This study investigated the best method for M2 occl…
View article: Differential Impact of Smoking on Intracerebral Hemorrhage Based on Cerebral Microbleed Status: A Case-Control Study
Differential Impact of Smoking on Intracerebral Hemorrhage Based on Cerebral Microbleed Status: A Case-Control Study Open
Background While smoking is a major cause of cardiovascular diseases, its association with intracerebral hemorrhage (ICH) remains controversial. Cerebral microbleeds (CMBs) serve as an imaging indicator of ICH, yet ICH can occur independen…
View article: Once- versus twice-daily direct oral anticoagulants after ischemic stroke in atrial fibrillation – A post-hoc analysis of the ELAN trial
Once- versus twice-daily direct oral anticoagulants after ischemic stroke in atrial fibrillation – A post-hoc analysis of the ELAN trial Open
Introduction: Whether the risk-benefit profile of once-daily versus twice-daily direct oral anticoagulants (DOAC) differs after atrial fibrillation(AF)-associated ischemic stroke is unclear. We explored this in a post-hoc analysis of ELAN …
View article: Differences in P2Y<sub>12</sub> Reaction Units Between Prasugrel and Clopidogrel by Ischemic Cerebrovascular Disease Subtypes ― Subanalysis From ACUTE-PRAS ―
Differences in P2Y<sub>12</sub> Reaction Units Between Prasugrel and Clopidogrel by Ischemic Cerebrovascular Disease Subtypes ― Subanalysis From ACUTE-PRAS ― Open
Prasugrel may have the potential to elicit stronger platelet aggregation inhibitory effects compared with clopidogrel in patients with acute LAA.
View article: Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST)
Collaboration on the optimal timing of anticoagulation after ischaemic stroke and atrial fibrillation: a systematic review and prospective individual participant data meta-analysis of randomised controlled trials (CATALYST) Open
View article: Prediction Model to Optimize Long-Term Antithrombotic Therapy Using Covert Vascular Brain Injury and Clinical Features
Prediction Model to Optimize Long-Term Antithrombotic Therapy Using Covert Vascular Brain Injury and Clinical Features Open
BACKGROUND: Defining the risk of developing major bleeding, especially intracranial hemorrhage (ICH), or ischemic stroke (IS) in patients receiving antithrombotic therapy is crucial. Existing risk prediction tools would inadequately assess…
View article: Oral Pathobiont <i>Streptococcus Anginosus</i> Is Enriched in the Gut of Stroke Patients and Predicts 2-Year Cardiovascular Outcome
Oral Pathobiont <i>Streptococcus Anginosus</i> Is Enriched in the Gut of Stroke Patients and Predicts 2-Year Cardiovascular Outcome Open
We analyzed the salivary and gut microbiomes collected from 189 acute stroke and 55 non-stroke subjects, and found that Streptococcus anginosus was significantly more abundant in both the saliva (median [IQR], 0.01 [0.00-0.14] vs. 0.00 [0.…
View article: Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis
Antiplatelet Use Prior to Anticoagulant Initiation in Patients With Atrial Fibrillation-Related Ischemic Stroke: An ELAN Trial Analysis Open
Background and Purpose Antiplatelets are often used before direct oral anticoagulant (DOACs) initiation after an acute ischemic stroke related to atrial fibrillation (AF), but the evidence is weak. Here, we explored the risks and benefits …
View article: Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation
Impact of Stroke Severity and Vascular Risk Factors on Early Versus Late Anticoagulation in Patients With Stroke and Atrial Fibrillation Open
View article: P2Y<sub>12</sub> Reaction Units With Prasugrel in Acute Large Artery Atherosclerosis and Transient Ischemic Attack: An Open-Label Randomized Controlled Study, ACUTE-PRAS
P2Y<sub>12</sub> Reaction Units With Prasugrel in Acute Large Artery Atherosclerosis and Transient Ischemic Attack: An Open-Label Randomized Controlled Study, ACUTE-PRAS Open
In patients with acute LAA or high-risk TIA, prasugrel resulted in stable inhibition of platelet aggregation 5 days after starting drug administration compared with clopidogrel, regardless of CYP2C19 polymorphisms.
View article: Current Status and Future Aspect of Digital Health Innovation in Stroke Prevention and Management
Current Status and Future Aspect of Digital Health Innovation in Stroke Prevention and Management Open
Digital health innovations (DHI) in medicine have led to remarkable progress in stroke prevention and management worldwide. For example, education regarding the knowledge and awareness of stroke, risk scores for stroke incidence, and weara…
View article: Clinical Characteristics, Risk Factors, and Outcomes of Arterial Dissection-Associated Stroke: A 22-Year Cohort Study from the Japan Stroke Data Bank
Clinical Characteristics, Risk Factors, and Outcomes of Arterial Dissection-Associated Stroke: A 22-Year Cohort Study from the Japan Stroke Data Bank Open
Ischemic stroke was the most frequent subtype of stroke in patients with arterial dissection, followed by SAH. Patients with stroke due to dissection were younger than those without. Neurological severity and older age at admission are sub…
View article: Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data
Efficacy and safety of intravenous alteplase for unknown onset stroke on prior antiplatelet therapy: Post hoc analysis of the EOS individual participant data Open
Background: The effects of intravenous alteplase in patients with prior antiplatelet therapy (APT) remain controversial. We aimed to assess the efficacy and safety of imaging-based intravenous alteplase in patients with unknown onset strok…
View article: Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation
Net Benefit of Early Anticoagulation for Stroke With Atrial Fibrillation Open
Importance The net clinical effect of early vs later direct oral anticoagulant (DOAC) initiation after atrial fibrillation–associated ischemic stroke is unclear. Objective To investigate whether early DOAC treatment is associated with a ne…
View article: Effects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials
Effects of sex on imaging-based intravenous thrombolysis for ischaemic stroke with unknown onset time: a pooled analysis of clinical trials Open
Introduction: The effects of imaging-based intravenous thrombolysis on outcomes based on patient sex remain unclear. We aimed to investigate whether outcomes among patients with stroke with an unknown onset time and treated with imaging-ba…
View article: Tenecteplase in Acute Ischemic Stroke: A Scientific Statement From the Korean Stroke Society
Tenecteplase in Acute Ischemic Stroke: A Scientific Statement From the Korean Stroke Society Open
These statements are intended to support the adoption of TNK in countries where it is not yet available, including South Korea, by providing up-to-date clinical evidence. Their implementation may broaden the therapeutic options for AIS pat…
View article: Atherogenic Dyslipidemia Is Critically Related to Aortic Complicated Lesions in Cryptogenic Stroke
Atherogenic Dyslipidemia Is Critically Related to Aortic Complicated Lesions in Cryptogenic Stroke Open
AD was not rare in the present CS population. Moreover, AD was crucially related to ACL in CS. Therefore, intensive and pleiotropic lipid-modifying therapy would be efficacious for further treatment of aortogenic brain embolism.
View article: Thrombus Age in Ischemic Stroke With Atrial Fibrillation: Impact on Mechanical Thrombectomy
Thrombus Age in Ischemic Stroke With Atrial Fibrillation: Impact on Mechanical Thrombectomy Open
View article: Optimal antithrombotic therapy in ischemic stroke patients with non-valvular atrial fibrillation and atherothrombosis: study protocol for a randomized controlled trial
Optimal antithrombotic therapy in ischemic stroke patients with non-valvular atrial fibrillation and atherothrombosis: study protocol for a randomized controlled trial Open
Background The addition of antiplatelet therapy to anticoagulant therapy in patients with stroke with non-valvular atrial fibrillation (NVAF) and atherothrombotic disease may increase bleeding risk without reducing recurrent stroke risk. A…
View article: Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds
Sex Differences in Frequency, Severity, and Distribution of Cerebral Microbleeds Open
Importance Cerebral small vessel disease (SVD) is associated with various cerebrovascular outcomes, but data on sex differences in SVD are scarce. Objective To investigate whether the frequency, severity, and distribution of cerebral micro…
View article: Severity, Outcomes, and their Secular Changes in 33,870 Ischemic Stroke Patients with Atrial Fibrillation in a Hospital-Based Registry: Japan Stroke Data Bank
Severity, Outcomes, and their Secular Changes in 33,870 Ischemic Stroke Patients with Atrial Fibrillation in a Hospital-Based Registry: Japan Stroke Data Bank Open
Initial stroke severity became milder and functional outcomes improved in AF patients over the 21-year period. These secular changes were steeper than in non-AF patients, suggesting that AF-associated stroke seemed to reap more benefit of …
View article: Effect of Hospital Arrival Time on Functional Prognosis of Stroke Patients: Japan Stroke Data Bank Over 20 Years
Effect of Hospital Arrival Time on Functional Prognosis of Stroke Patients: Japan Stroke Data Bank Over 20 Years Open
Stroke patients admitted on weekends/holidays and off-hours had worse functional and life outcomes. Functional outcomes for off-hour admission for IS improved at 10-year intervals, possibly due to improvements in stroke care systems.
View article: Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial
Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial Open
View article: Pupillometer-Based Neurological Pupil Index Differential: A Potential Predictor of Post-Stroke Delirium
Pupillometer-Based Neurological Pupil Index Differential: A Potential Predictor of Post-Stroke Delirium Open
View article: Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation
Early vs Late Anticoagulation in Minor, Moderate, and Major Ischemic Stroke With Atrial Fibrillation Open
Importance Whether infarct size modifies the treatment effect of early vs late direct oral anticoagulant (DOAC) initiation in people with ischemic stroke and atrial fibrillation is unknown. Objective To assess whether infarct size modifies…
View article: Predictive Value of Midregional Pro–Atrial Natriuretic Peptide for Cardioembolic Stroke in Hyperacute Ischemic Stroke
Predictive Value of Midregional Pro–Atrial Natriuretic Peptide for Cardioembolic Stroke in Hyperacute Ischemic Stroke Open
View article: Issue Information
Issue Information Open
OARE initiatives.They are now collectively known as Research4Life, making online scientific content available free or at nominal cost to researchers in developing countries and enabling more researchers to publish open access by providing