Masatoshi Sakurai
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View article: Differential trends in survival after allogeneic transplantation for MDS and MDS/MPN in a real-world experience
Differential trends in survival after allogeneic transplantation for MDS and MDS/MPN in a real-world experience Open
Introduction Recent advances in allogeneic hematopoietic stem cell transplantation (allo-HSCT) strategies and supportive care may have increased access to allo-HSCT and improved post-transplant outcomes in myeloid neoplasms. To clarify sur…
View article: Risk Factors for and Impact of Pre‐Engraftment Syndrome on Outcomes Following Single‐Unit Cord Blood Transplantation in Adults
Risk Factors for and Impact of Pre‐Engraftment Syndrome on Outcomes Following Single‐Unit Cord Blood Transplantation in Adults Open
Pre‐engraftment syndrome (PES) is a unique complication of cord blood transplantation (CBT) whose risk factors and impact on transplant outcomes remain controversial. Using a nationwide database in Japan, we analyzed a total of 3734 patien…
View article: Successful repeated endoscopic balloon dilatation for esophageal stricture as chronic graft‐versus‐host disease
Successful repeated endoscopic balloon dilatation for esophageal stricture as chronic graft‐versus‐host disease Open
View article: Treatment burden in patients with paroxysmal nocturnal hemoglobinuria: an in-depth interview survey
Treatment burden in patients with paroxysmal nocturnal hemoglobinuria: an in-depth interview survey Open
Paroxysmal nocturnal hemoglobinuria (PNH) is a lifelong, clonal hematologic disease posing life-threatening risks if untreated. The prognosis for PNH has improved with the advent of C5 inhibitors, which are now the standard of care where a…
View article: Classical and Late‐Onset <scp>SOS</scp>/<scp>VOD</scp> After Allogeneic <scp>HSCT</scp>: A Japanese Transplant Registry Analysis
Classical and Late‐Onset <span>SOS</span>/<span>VOD</span> After Allogeneic <span>HSCT</span>: A Japanese Transplant Registry Analysis Open
Sinusoidal obstruction syndrome/veno‐occlusive disease (SOS/VOD) is a lethal complication of allogeneic hematopoietic stem cell transplantation (allo‐HSCT). According to the 2016 European Society for Blood and Marrow Transplantation criter…
View article: Impact of prior solid tumors and their treatment modality on outcomes after allogeneic hematopoietic stem cell transplantation: A KSGCT multi-center retrospective study
Impact of prior solid tumors and their treatment modality on outcomes after allogeneic hematopoietic stem cell transplantation: A KSGCT multi-center retrospective study Open
Despite the increasing number of cancer survivors, the impact of prior solid tumors and their treatment modality on outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT) remains unclear. This multi-center retrospect…
View article: Comparative analysis of allogeneic hematopoietic cell transplantation in patients with therapy-related and de novo acute promyelocytic leukemia A retrospective study
Comparative analysis of allogeneic hematopoietic cell transplantation in patients with therapy-related and de novo acute promyelocytic leukemia A retrospective study Open
Although allogeneic hematopoietic cell transplantation (HCT) is an alternative treatment for relapsed or refractory (R/R) acute promyelocytic leukemia (APL), little is known regarding the utility of allogeneic HCT for R/R therapy-related A…
View article: Unmet Needs and Health‐Related Quality of Life Among Patients With Relapsed/Refractory Indolent Non‐Hodgkin Lymphoma: A Mixed‐Methods Study
Unmet Needs and Health‐Related Quality of Life Among Patients With Relapsed/Refractory Indolent Non‐Hodgkin Lymphoma: A Mixed‐Methods Study Open
Objective Patients with relapsed or refractory (r/r) indolent non‐Hodgkin lymphoma (iNHL) live with incurable disease for a long‐term, experiencing multiple relapses and treatments that impair their health‐related quality of life (HRQOL). …
View article: Successful Antibiotic Treatment of Phlegmonous Gastritis Following Allogeneic Hematopoietic Stem Cell Transplantation
Successful Antibiotic Treatment of Phlegmonous Gastritis Following Allogeneic Hematopoietic Stem Cell Transplantation Open
Phlegmonous gastritis (PG) is a rare, life-threatening bacterial infection characterized by thickening of the gastric wall. We report a case of PG in a 17-year-old male following allogeneic hematopoietic stem cell transplantation for sever…
View article: Persistent Unilateral Pleural Effusion with Chimeric Antigen Receptor T-cell Infiltration in Primary Mediastinal Large B-cell Lymphoma
Persistent Unilateral Pleural Effusion with Chimeric Antigen Receptor T-cell Infiltration in Primary Mediastinal Large B-cell Lymphoma Open
Pleural effusion following chimeric antigen receptor (CAR) T-cell therapy is typically transient, bilateral, and associated with cytokine release syndrome (CRS). We herein report persistent unilateral massive pleural effusion with CAR T-ce…
View article: Perspectives on the continuing community lives of individuals with mental disabilities in regional Japan: from the viewpoint of personal recovery
Perspectives on the continuing community lives of individuals with mental disabilities in regional Japan: from the viewpoint of personal recovery Open
Professionals must believe in the ability of individuals with mental disorders to achieve personal recovery and persistently support their choices and decisions. It is necessary to build a recovery-oriented and comprehensive community care…
View article: Post-transplant transient abnormal myelopoiesis evolving from a GATA1 mutant clone in umbilical cord blood
Post-transplant transient abnormal myelopoiesis evolving from a GATA1 mutant clone in umbilical cord blood Open
Transient abnormal myelopoiesis (TAM) generally affects newborns with Down syndrome and is associated with constitutional trisomy 21 and a somatic GATA1 mutation. Here we describe a case of TAM which evolved after umbilical cord blood tran…
View article: Multiple Subcutaneous Abscesses by <i>Corynebacterium Amycolatum</i> in a Patient with Severe Idiopathic Aplastic Anaemia
Multiple Subcutaneous Abscesses by <i>Corynebacterium Amycolatum</i> in a Patient with Severe Idiopathic Aplastic Anaemia Open
Corynebacterium amycolatum is a part of the normal skin flora and has been underestimated as a pathogen. However, in recent years, the species has gained recognition as an important pathogen causing severe infections, particularly in immun…
View article: Ex vivo expansion of human hematopoietic stem cells and clinical applications
Ex vivo expansion of human hematopoietic stem cells and clinical applications Open
Hematopoietic stem cells (HSCs) are a rare population of cells found in the bone marrow that play a critical role in lifelong hematopoiesis and the reconstitution of the hematopoietic system after hematopoietic stem cell transplantation. H…
View article: Salivary gland swelling as a characteristic manifestation of local cytokine release syndrome after anti-CD19 chimeric antigen receptor T cell therapy: A case series
Salivary gland swelling as a characteristic manifestation of local cytokine release syndrome after anti-CD19 chimeric antigen receptor T cell therapy: A case series Open
Cytokine release syndrome (CRS) is the most common adverse event of chimeric antigen receptor T (CAR-T) cell therapy and is usually characterized by systemic symptoms such as fever, hypotension, and hypoxia. However, there have been severa…
View article: Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study
Updated comparable efficacy of cord blood transplantation for chronic myelomonocytic leukaemia: a nationwide study Open
Chronic myelomonocytic leukaemia (CMML) is a haematological malignancy with a poor prognosis. Allogeneic haematopoietic stem cell transplantation remains the only curative approach. Without human leukocyte antigen-matched related sibling d…
View article: Differential clinical impact of letermovir prophylaxis according to graft sources: a KSGCT multicenter retrospective analysis
Differential clinical impact of letermovir prophylaxis according to graft sources: a KSGCT multicenter retrospective analysis Open
Clinically significant cytomegalovirus infection (csCMVi) is frequently observed after allogeneic hematopoietic stem cell transplantation (HSCT) and prophylaxis with letermovir is commonly adopted. However, the clinical benefit of letermov…
View article: Chemically defined cytokine-free expansion of human haematopoietic stem cells
Chemically defined cytokine-free expansion of human haematopoietic stem cells Open
The ex vivo expansion of human hematopoietic stem/progenitor cells (HSPCs) has important applications in both basic research and clinical transplantation therapy. Here, we introduce the protocol of a novel culture system that supports the …
View article: Long-term reduction in the incidence of aplastic anemia and immune thrombocytopenia during the COVID-19 pandemic
Long-term reduction in the incidence of aplastic anemia and immune thrombocytopenia during the COVID-19 pandemic Open
Not available.
View article: Progress in survival following three decades of allogeneic hematopoietic cell transplantation for myelodysplastic syndrome: A real‐world registry study in Japan
Progress in survival following three decades of allogeneic hematopoietic cell transplantation for myelodysplastic syndrome: A real‐world registry study in Japan Open
Allogeneic hematopoietic cell transplantation (HCT) can eradicate myelodysplastic syndrome (MDS) clones through high-dose chemoradiotherapy and the graft-versus-tumor effect,1 and it remains the only potentially curative treatment modality…
View article: Recent advances in ex vivo expansion of human hematopoietic stem cells
Recent advances in ex vivo expansion of human hematopoietic stem cells Open
Hematopoietic stem cells (HSCs) are a rare cell population present in the bone marrow. They possess self-renewal and multipotent differentiation capacities and play a crucial role in lifelong hematopoiesis and reconstitution of the hematop…
View article: The impact of pretransplant use of tyrosine kinase inhibitors on allogeneic stem cell transplantation in patients with chronic myeloid leukemia - A single-institution retrospective study
The impact of pretransplant use of tyrosine kinase inhibitors on allogeneic stem cell transplantation in patients with chronic myeloid leukemia - A single-institution retrospective study Open
Second- and third-generation (2/3G) tyrosine kinase inhibitors (TKIs) possess excellent treatment effects on chronic myeloid leukemia (CML), and at least one 2/3G TKI is mostly incorporated into the first treatment of CML in all phases. Ho…
View article: Impact of standard-dose dipeptidyl peptidase-4 inhibitors on the incidence of graft-versus-host disease among diabetes mellitus patients undergoing allogeneic hematopoietic cell transplantation: a KSGCT multicenter retrospective study
Impact of standard-dose dipeptidyl peptidase-4 inhibitors on the incidence of graft-versus-host disease among diabetes mellitus patients undergoing allogeneic hematopoietic cell transplantation: a KSGCT multicenter retrospective study Open
This study aimed to evaluate the impact of standard-dose dipeptidyl peptidase-4 inhibitors (DPP-4i) on the incidence of graft-versus-host disease (GVHD) after allogeneic hematopoietic cell transplantation (HCT). We retrospectively evaluate…
View article: Simultaneous quantification of dasatinib, nilotinib, bosutinib, and ponatinib using high‐performance liquid chromatography–Photodiode array detection
Simultaneous quantification of dasatinib, nilotinib, bosutinib, and ponatinib using high‐performance liquid chromatography–Photodiode array detection Open
Background Dasatinib, nilotinib, and bosutinib, second‐generation tyrosine kinase inhibitors (TKIs), and ponatinib, a third‐generation TKI, are approved pharmaceuticals used in the treatment of chronic myeloid leukemia (CML). Although liqu…
View article: Concurrent <i>de novo</i> Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review
Concurrent <i>de novo</i> Thymoma-associated Paraneoplastic Type 1 Autoimmune Hepatitis and Pure Red Cell Aplasia after Thymectomy: A Case Report and Literature Review Open
The precise manipulation of immune tolerance is the holy grail of immunotherapies for both autoimmunity and cancer immunity. Thymomas are well known to be associated with autoimmune diseases. The exact mechanism by which autoreactivity is …
View article: Adoptive cell therapy using tumor‐infiltrating lymphocytes for melanoma refractory to immune‐checkpoint inhibitors
Adoptive cell therapy using tumor‐infiltrating lymphocytes for melanoma refractory to immune‐checkpoint inhibitors Open
To evaluate the feasibility of adoptive cell therapy (ACT) using ex vivo‐expanded tumor‐infiltrating lymphocytes (TILs) in Japanese patients with melanoma who failed immune‐checkpoint inhibitor therapy, an open‐label, single‐arm, pilot stu…
View article: Efficacy of ondansetron against emesis induced by a multiple-day cisplatin-based chemotherapy regimen for malignant lymphoma
Efficacy of ondansetron against emesis induced by a multiple-day cisplatin-based chemotherapy regimen for malignant lymphoma Open
Although NK1RA is generally recommended for cisplatin-containing regimen, our results suggest that ondansetron effectively controlled emesis in patients receiving ESHAP therapy which includes high-dose corticosteroid.
View article: Impact of Specific Antibody Level on Human Herpesvirus 6 Reactivation after Allogeneic Stem Cell Transplantation
Impact of Specific Antibody Level on Human Herpesvirus 6 Reactivation after Allogeneic Stem Cell Transplantation Open
The majority of adults are seropositive for human herpesvirus 6 (HHV-6). HHV-6 reactivation can occur after allogeneic hematopoietic stem cell transplantation (HSCT) and lead to life-threatening central nervous system disorders. In this pr…
View article: Erratum to: Human Herpesvirus 6 Reactivation Evaluated by Digital Polymerase Chain Reaction and Its Association With Dynamics of CD134-Positive T Cells After Allogeneic Hematopoietic Stem Cell Transplantation
Erratum to: Human Herpesvirus 6 Reactivation Evaluated by Digital Polymerase Chain Reaction and Its Association With Dynamics of CD134-Positive T Cells After Allogeneic Hematopoietic Stem Cell Transplantation Open
View article: Effects of Co-administration of Proton Pump Inhibitors on Methotrexate Elimination and Adverse Events
Effects of Co-administration of Proton Pump Inhibitors on Methotrexate Elimination and Adverse Events Open
Co-administration of methotrexate (MTX) and proton pump inhibitors (PPIs) is reported to increase serum MTX concentrations in patients receiving high-dose MTX therapy. However, the range of MTX high dosage is wide. We attempted to clarify …