Explanipedia

Blood pressure during long-term cilostazol-based dual antiplatelet therapy after stroke: a post hoc analysis of the CSPS.com trial Open

Ḱazunori Toyoda, Masatoshi Koga, Kenta Tanaka, Shinichiro Uchiyama, Hisato Sunami , et al. · 2024

We determined the associations of follow-up blood pressure (BP) after stroke as a time-dependent covariate with the risk of subsequent ischemic stroke, as well as those of BP levels with the difference in the impact of long-term clopidogre…

Female “Paradox” in Atrial Fibrillation—Role of Left Truncation Due to Competing Risks Open

Tomoki Nakamizo, Munechika Misumi, Tetsuya Takahashi, Satoshi Kurisu, Masayasu Matsumoto , et al. · 2023

Female sex in patients with atrial fibrillation (AF) is a controversial and paradoxical risk factor for stroke—controversial because it increases the risk of stroke only among older women of some ethnicities and paradoxical because it appe…

Dual Antiplatelet Therapy With Cilostazol for Secondary Prevention in Lacunar Stroke: Subanalysis of the CSPS.com Trial Open

Yasuhiro Nishiyama, Kazumi Kimura, Toshiaki Otsuka, Ḱazunori Toyoda, Shinichiro Uchiyama , et al. · 2023

Background: The effectiveness of long-term dual antiplatelet therapy (DAPT) to prevent recurrent strokes in patients with lacunar stroke remains unclarified. Therefore, this study aimed to compare and to elucidate the safety and effectiven…

Dual Antiplatelet Therapy Using Cilostazol in Patients With Stroke and Intracranial Arterial Stenosis Open

Shinichiro Uchiyama, Ḱazunori Toyoda, Katsuhiro Omae, Ryotaro Saita, Kazumi Kimura , et al. · 2021

Background Long‐term benefit of dual antiplatelet therapy (DAPT) over single antiplatelet therapy (SAPT) for the prevention of recurrent stroke has not been established in patients with intracranial arterial stenosis. We compared the effic…

Dual Antiplatelet Therapy Using Cilostazol With Aspirin or Clopidogrel: Subanalysis of the CSPS.com Trial Open

Haruhiko Hoshino, Ḱazunori Toyoda, Katsuhiro Omae, Noriyuki Ishida, Shinichiro Uchiyama , et al. · 2021

Background and Purpose: Although dual antiplatelet therapy (DAPT) with aspirin and clopidogrel reduces the recurrence of ischemic stroke while significantly increasing the bleeding events compared with monotherapy, the CSPS.com trial (Cilo…

Radiation effects on atherosclerosis in atomic bomb survivors: a cross‐sectional study using structural equation modeling Open

Tomoki Nakamizo, John Cologne, Kismet A. Cordova, Michiko Yamada, Tetsuya Takahashi , et al. · 2021

Blood Pressure Level and Variability During Long-Term Prasugrel or Clopidogrel Medication After Stroke Open

Ḱazunori Toyoda, Hiroshi Yamagami, Kazuo Kitagawa, Takanari Kitazono, Takehiko Nagao , et al. · 2021

Background and Purpose: High blood pressure increases bleeding risk during treatment with antithrombotic medication. The association between blood pressure levels and the risk of recurrent stroke during long-term secondary stroke preventio…

Transient ischemic attack without self‐awareness of symptoms witnessed by bystanders: analysis of the PROMISE‐TIA registry Open

Kõji Tanaka, Toshiyuki Uehara, Tomoyuki Ohara, Shoichiro Sato, Masayo Hayakawa , et al. · 2020

Background and purpose A transient ischemic attack (TIA) can occur without self‐awareness of symptoms. We aimed to investigate characteristics of patients with a tissue‐based diagnosis of TIA but having no self‐awareness of their symptoms …

A case of COVID-19 infection presenting with a seizure following severe brain edema Open

Yoshinori Kadono, Yusaku Nakamura, Yoshihiko Ogawa, Shota Yamamoto, Ryuichiro Kajikawa , et al. · 2020

Efficacy and Safety of Prasugrel by Stroke Subtype: A Sub-Analysis of the PRASTRO-I Randomized Controlled Trial Open

Takanari Kitazono, Ḱazunori Toyoda, Kazuo Kitagawa, Takehiko Nagao, Hiroshi Yamagami , et al. · 2020

Although statistical significance was not reached, the efficacy of prasugrel was potentially different between stroke subtypes, warranting further studies.

Issue Information Open

Shiu Kum Lam, Hong Kong, Kunio Okuda, Chiba Lawrie, William A. Powell , et al. · 2020

Influence of pretreatment tumor growth rate

Detection of paroxysmal atrial fibrillation in patient with embolic stroke by active self-management education: a case report Open

Yasuko Fukuoka, Aya Ogura, Yasuhiro Ito, Chitose Mae, Kayoko Tomita , et al. · 2019

要旨：症例は65 歳男性．突然の左視野障害を自覚し，受診．頭部MRI 上，右後頭葉に梗塞巣を認め，塞栓性機序を疑ったが，発作性を含め心房細動は見いだされず，embolic stroke of undetermined source としてフォローした．脳梗塞再発予防の疾病管理プログラム研究へ参加し，疾病管理ナースが，不整脈の発見を目標に，血圧と脈拍の自己測定を含むセルフマネジメント教育を行った．発症後86 日目，患者自らが血圧と脈拍の異常に気づき，看護師に連絡した．看護師は…

Effect of Statin on Stroke Recurrence Prevention at Different Infarction Locations: A Post Hoc Analysis of The J-STARS Study Open

Tomohisa Nezu, Naohisa Hosomi, Kazuo Kitagawa, Yoji Nagai, Yoko Nakagawa , et al. · 2019

Pravastatin significantly reduced the recurrence rate of all stroke among patients with PCS. Thus, the effect of statin on the recurrence of stroke may differ according to infarction location.

Different Influences of Statin Treatment in Preventing At-Risk Stroke Subtypes: A Post Hoc Analysis of J-STARS Open

Naohisa Hosomi, Kazuo Kitagawa, Yoji Nagai, Yoko Nakagawa, Shiro Aoki , et al. · 2019

Statins showed different influences on the risks of atherothromobotic and lacunar stroke according to postrandomized LDL cholesterol levels.

Baseline Carotid Intima-Media Thickness and Stroke Recurrence During Secondary Prevention With Pravastatin Open

Shinichi Wada, Masatoshi Koga, Kazuo Minematsu, Ḱazunori Toyoda, Riéko Suzuki , et al. · 2019

Background and Purpose— As a prespecified post hoc analysis of the J-STARS (Japan Statin Treatment Against Recurrent Stroke) Echo Study, the 5-year stroke recurrence rate according to the baseline mean carotid intima-media thickness (IMT) …

Physiological parameters of cerebral small-vessel disease Open

Ryosuke Doijiri, Kozue Saito, Shinichiro Uchiyama, Kazuo Kitagawa, Hidehiro Takekawa , et al. · 2019

Objective: Lacunar infarction and intracerebral hemorrhage (ICH) have common characteristics of cerebral small-vessel disease (CSVD) although they are classified as different stroke subtypes.Previous studies showed a positive correlation o…

Low-Dose Aspirin for Primary Prevention of Cardiovascular Events in Elderly Japanese Patients with Atherosclerotic Risk Factors: Subanalysis of a Randomized Clinical Trial (JPPP-70) Open

Masahiro Sugawara, Yoshio Gotō, Tsutomu Yamazaki, Tamio Teramoto, Shinichi Oikawa , et al. · 2018

The study is registered at ClinicalTrials.gov [NCT00225849].

Association Between Prevalence of Peripheral Artery Disease and Radiation Exposure in the Atomic Bomb Survivors Open

Ikuno Takahashi, John Cologne, Daisuke Haruta, Michiko Yamada, Tetsuya Takahashi , et al. · 2018

Background Past reports suggested that total‐body irradiation at 0.5 to 1.0 Gy could be responsible for atherosclerosis. Peripheral artery disease ( PAD ) is a manifestation of systematic atherosclerosis. Whether the consequences of a low‐…

Cumulative Effects of LDL Cholesterol and CRP Levels on Recurrent Stroke and TIA Open

Kazuo Kitagawa, Naohisa Hosomi, Yoji Nagai, Tatsuo Kagimura, Toshiho Ohtsuki , et al. · 2018

The control of both LDL cholesterol and CRP levels appears to be effective for preventing recurrent stroke and TIA in patients with non-cardiogenic ischemic stroke.

A Case of Multiple Cerebral Infarctions Associated with Giant Ovarian Mucinous Adenocarcinoma: Trousseau Syndrome Open

Chihiro Akiyama, Masahiro Asaeda, Masayuki Yokota, Mamoru Tane, Tsutomu Takahashi , et al. · 2018

Trousseau症候群は悪性腫瘍に伴う血液凝固亢進により脳卒中を生じる病態とされ卵巣癌での発症は多いが，卵巣粘液性腺癌での発症報告はほとんどなく，今回経験したので報告する。症例は70歳女性。見当識障害で受診し多発性脳梗塞を認め，精査にて卵巣粘液性腺癌を認めた。粘液性腺癌の進行は緩徐だが進行例は予後不良とされ，今回も急激な経過を辿ったが，治療ではCA125などで病勢を予測しての抗凝固療法や原疾患の速やかな治療が肝要と思われる。

4′,6-Diamidino-2-Phenylindole Distinctly Labels Tau Deposits Open

Chengyu Li, Tetsuya Takahashi, Tejashwi Shrestha, Eiji Kinoshita, Tomoyasu Matsubara , et al. · 2018

Tau deposits have distinct biochemical characteristics and vary morphologically based on identification with tau antibodies and several chemical dyes. Here, we report 4′,6-diamidino-2-phenylindole (DAPI)-positivity of tau deposits. Further…

Effects of controlled abnormal joint movement on the molecular biological response in intra-articular tissues during the acute phase of anterior cruciate ligament injury in a rat model Open

Yuichi Nishikawa, Takanori Kokubun, Naohiko Kanemura, Tetsuya Takahashi, Masayasu Matsumoto , et al. · 2018

High-Dose Versus Low-Dose Pitavastatin in Japanese Patients With Stable Coronary Artery Disease (REAL-CAD) Open

Isao Taguchi, Satoshi Iimuro, Hiroshi Iwata, Hiroaki Takashima, Mitsuru Abe , et al. · 2018

Background: Current guidelines call for high-intensity statin therapy in patients with cardiovascular disease on the basis of several previous “more versus less statins” trials. However, no clear evidence for more versus less statins has b…

A noninferiority confirmatory trial of prasugrel versus clopidogrel in Japanese patients with non-cardioembolic stroke: rationale and study design for a randomized controlled trial – PRASTRO-I trial Open

Takehiko Nagao, Ḱazunori Toyoda, Kazuo Kitagawa, Takanari Kitazono, Hiroshi Yamagami , et al. · 2018

Background: This comparison of PRAsugrel and clopidogrel in Japanese patients with ischemic STROke (PRASTRO)-I trial investigates the noninferiority of prasugrel to clopidogrel sulfate in the prevention of recurrence of primary even…

N018 Nursing intervention improves medication adherence to thiopurines in IBD outpatients: A single-centre prospective study Open

Masumi Okuda, K Sakagami, Masayasu Matsumoto, Ito H, Shinichiro Shinzaki · 2018

Thiopurines are widely used immunomodulators for maintaining remission of patients with inflammatory bowel disease (IBD). However, there are few reports showing the real-world data of medication adherence to thiopurines for adult IBD patie…

Ultrasonographic measurement of cross-sectional area of the median and ulnar nerves in healthy Japanese children Open

Takamichi Sugimoto, Kazuhide Ochi, Τakeshi Kitamura, Kazuki Muguruma, Tatsuo Kohriyama , et al. · 2018

Ultrasonography is a painless and rapid method, which is attractive for testing in children. The objective of this study was to try to measure a cross-sectional area (CSA) at predetermined sites along the median and ulnar nerves in childre…

Effects of Cilnidipine, an L/N-Type Calcium Channel Blocker, on Carotid Atherosclerosis in Japanese Post-Stroke Hypertensive Patients: Results from the CA-ATTEND Study Open

Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Norihiro Suzuki, Tsukasa Teshima , et al. · 2017

Cilnidipine promoted the regression of common carotid IMT in post-stroke hypertensive patients, especially in the thick group. Cilnidipine also reduced the IAD in both normal and thick groups.

Long-Term Effect of Pravastatin on Carotid Intima–Media Complex Thickness Open

Masatoshi Koga, Ḱazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka, Yoji Nagai , et al. · 2017

Background and Purpose— The effect of statins on progression of carotid intima–media complex thickness (IMT) has been shown exclusively in nonstroke Western patients. This study aimed to determine the effect of low-dose pravastatin on caro…

Factors Associated with Intima-Media Complex Thickness of the Common Carotid Artery in Japanese Noncardioembolic Stroke Patients with Hyperlipidemia: The J-STARS Echo Study Open

Shinichi Wada, Masatoshi Koga, Ḱazunori Toyoda, Kazuo Minematsu, Masahiro Yasaka , et al. · 2017

Baseline mean and maximum values of carotid IMT in Japanese noncardioembolic stroke patients with hyperlipidemia were 0.89±0.15 mm and 1.19±0.32 mm, respectively, which were similar to those previously reported from Western countries. Age,…

Alpha-2-macroglobulin as a Promising Biological Marker of Endothelial Function Open

Ryo Shimomura, Tomohisa Nezu, Naohisa Hosomi, Shiro Aoki, Takamichi Sugimoto , et al. · 2017

Serum _α2MG levels might reflect endothelial dysfunction evaluated by FMD in patients with chronic stroke or cardiovascular risk factors.

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