Masego Mmatli
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View article: Evaluation of Six Commercial and Noncommercial Colistin Resistance Diagnostics
Evaluation of Six Commercial and Noncommercial Colistin Resistance Diagnostics Open
Resistance to colistin, a last‐reserve antibiotic used for treating drug‐resistant infections, is rising globally. We compared six commercial and in‐house diagnostics—ComASP colistin, CHROMagar COL‐APSE, rapid polymyxin NP (Nordmann/Poirel…
View article: <i>Enterobacterales</i> use capsules, transporters, mobile genetic elements, and other evolutionary adaptations to survive antibiotics exposure in the absence of resistance genes
<i>Enterobacterales</i> use capsules, transporters, mobile genetic elements, and other evolutionary adaptations to survive antibiotics exposure in the absence of resistance genes Open
In the absence of canonical carbapenemase and mcr genes, K. pneumoniae and Enterobacter species can deploy a spectrum of adaptive mechanisms, including efflux pumps, mobile elements, and altered outer membrane/capsule structures, to overco…
View article: Plasmid-borne <i>mcr-1</i> and replicative transposition of episomal and chromosomal <i>bla</i> <sub>NDM-1</sub> , <i>bla</i> <sub>OXA-69</sub> , and <i>bla</i> <sub>OXA-23</sub> carbapenemases in a clinical <i>Acinetobacter baumannii</i> isolate
Plasmid-borne <i>mcr-1</i> and replicative transposition of episomal and chromosomal <i>bla</i> <sub>NDM-1</sub> , <i>bla</i> <sub>OXA-69</sub> , and <i>bla</i> <sub>OXA-23</sub> carbapenemases in a clinical <i>Acinetobacter baumannii</i> isolate Open
A multidrug-resistant clinical Acinetobacter baumannii isolate with resistance to most antibiotics was isolated from a patient at an intensive care unit. The genetic environment, transcriptome, mobile, and resistome were characterized. The…
View article: Plasmid-borne<i>mcr-1</i>and Replicative Transposition of Episomal and Chromosomal blaNDM-1, blaOXA-69, and blaOXA-23 Carbapenemases in a Clinical<i>Acinetobacter baumannii</i>Isolate
Plasmid-borne<i>mcr-1</i>and Replicative Transposition of Episomal and Chromosomal blaNDM-1, blaOXA-69, and blaOXA-23 Carbapenemases in a Clinical<i>Acinetobacter baumannii</i>Isolate Open
Background A multidrug-resistant clinical A. baumannii isolate with resistance to most antibiotics was isolated from a patient at an intensive care unit. The genetic environment, transcriptome, mobile, and resistome were characterized. Met…
View article: Evaluation of Six Commercial and Non-Commercial Colistin Resistance Diagnostics
Evaluation of Six Commercial and Non-Commercial Colistin Resistance Diagnostics Open
Background Resistance to colistin, a last-reserve antibiotic used for treating drug-resistant infections, is increasing globally. This study evaluated six diagnostic tests designed to detect colistin-resistant pathogens. Methods PCR and br…
View article: Molecular epidemiology of multidrug-resistant Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli outbreak among neonates in Tembisa hospital, South Africa
Molecular epidemiology of multidrug-resistant Klebsiella pneumoniae, Enterobacter cloacae, and Escherichia coli outbreak among neonates in Tembisa hospital, South Africa Open
Background An outbreak of multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae infections in a neonatal ward within a tertiary hospital in South Africa resulted in the mortality of 10 patients within six mo…
View article: Genomic, Epigenomic, and Transcriptional Characterisation of Carbapenem and Colistin Resistance Mechanisms in<i>Klebsiella pneumoniae</i>and<i>Enterobacter</i>species
Genomic, Epigenomic, and Transcriptional Characterisation of Carbapenem and Colistin Resistance Mechanisms in<i>Klebsiella pneumoniae</i>and<i>Enterobacter</i>species Open
The emergence of colistin and carbapenem-resistant Klebsiella pneumoniae isolates presents a significant global health threat. This study investigates the resistance mechanisms in six K. pneumoniae and four Enterobacter sp. isolates lackin…
View article: Molecular Epidemiology of multidrug-resistant<i>Klebsiella pneumoniae, Enterobacter cloacae,</i>and<i>Escherichia coli</i>outbreak among neonates in Tembisa Hospital, South Africa
Molecular Epidemiology of multidrug-resistant<i>Klebsiella pneumoniae, Enterobacter cloacae,</i>and<i>Escherichia coli</i>outbreak among neonates in Tembisa Hospital, South Africa Open
Background An outbreak of multidrug-resistant Klebsiella pneumoniae, Escherichia coli, and Enterobacter cloacae infections in a neonatal ward within a tertiary hospital in South Africa resulted in the mortality of 10 patients within six mo…
View article: Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update
Global epidemiology, genetic environment, risk factors and therapeutic prospects of mcr genes: A current and emerging update Open
Background Mobile colistin resistance ( mcr ) genes modify Lipid A molecules of the lipopolysaccharide, changing the overall charge of the outer membrane. Results and discussion Ten mcr genes have been described to date within eleven Enter…
View article: Global Epidemiology and Genetic Environment of mcr genes: A One Health Systematic Review of Current and Emerging Trends
Global Epidemiology and Genetic Environment of mcr genes: A One Health Systematic Review of Current and Emerging Trends Open
Background: Mobile colistin resistance (mcr) genes modify Lipid A molecules of the lipopolysaccharide, changing the overall charge of the outer membrane. Methods: A systematic review of all studies published between January 2015 to July 20…
View article: Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in <i>Enterobacteriaceae</i> : a Systematic Review of Current Reports
Emerging Transcriptional and Genomic Mechanisms Mediating Carbapenem and Polymyxin Resistance in <i>Enterobacteriaceae</i> : a Systematic Review of Current Reports Open
The spread of carbapenem- and polymyxin-resistant Enterobacteriaceae poses a significant threat to public health, challenging clinicians worldwide with limited therapeutic options. This review describes the current coding and noncoding gen…