Explanipedia

A Translational Neuroscience & Computational Evaluation of a D1R Partial Agonist for Schizophrenia (TRANSCENDS): Rationale and Study Design of a Brain-Based Clinical Trial Open

Clara Fonteneau, Zailyn Tamayo, Ally Price, Lining Pan, Yvette Afriyie-Agyemang , et al. · 2025

Despite decades of research, cognitive impairment remains a critical untreated symptom for many patients with schizophrenia. One way to accelerate the development of pro-cognitive therapies for schizophrenia is to evaluate compounds using …

A common symptom geometry of mood improvement under sertraline and placebo associated with distinct neural patterns Open

Lucie Berkovitch, Kangjoo Lee, Jie Ji, Markus Helmer, Masih Rahmati , et al. · 2025

Background Understanding the mechanisms of major depressive disorder (MDD) improvement is a key challenge to determining effective personalized treatments. Methods To identify a data-driven pattern of clinical improvement in MDD and to qua…

Human brain state dynamics are highly reproducible and associated with neural and behavioral features Open

Kangjoo Lee, Jie Lisa Ji, Clara Fonteneau, Lucie Berkovitch, Masih Rahmati , et al. · 2024

Neural activity and behavior vary within an individual (states) and between individuals (traits). However, the mapping of state-trait neural variation to behavior is not well understood. To address this gap, we quantify moment-to-moment ch…

Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks Open

Nina Purg Suljič, Aleksij Kraljič, Masih Rahmati, Youngsun Cho, Anka Slana Ozimič , et al. · 2024

Spatial locations can be encoded and maintained in working memory using different representations and strategies. Fine-grained representations provide detailed stimulus information, but are cognitively demanding and prone to inexactness. T…

Ketamine induces multiple individually distinct whole-brain functional connectivity signatures Open

Flora Moujaes, Jie Lisa Ji, Masih Rahmati, Joshua B. Burt, Charles Schleifer , et al. · 2024

Background: Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine’s molecul…

Author response: Ketamine induces multiple individually distinct whole-brain functional connectivity signatures Open

Flora Moujaes, Jie Lisa Ji, Masih Rahmati, Joshua B. Burt, Charles Schleifer , et al. · 2024

Full text Figures and data Peer review Side by side Abstract Editor's evaluation eLife digest Introduction Materials and methods Results Discussion Data availability References Article and author information Metrics Abstract Background: Ke…

A common symptom geometry of mood improvement under sertraline and placebo associated with distinct neural patterns Open

Lucie Berkovitch, Kangjoo Lee, Jie Lisa Ji, Markus Helmer, Masih Rahmati , et al. · 2023

Importance Understanding the mechanisms of major depressive disorder (MDD) improvement is a key challenge to determine effective personalized treatments. Objective To perform a secondary analysis quantifying neural-to-symptom relationships…

Human brain state dynamics reflect individual neuro-phenotypes Open

Kangjoo Lee, Jie Lisa Ji, Clara Fonteneau, Lucie Berkovitch, Masih Rahmati , et al. · 2023

Neural activity and behavior vary within an individual (states) and between individuals (traits). However, the mapping of state-trait neural variation to behavior is not well understood. To address this gap, we quantify moment-to-moment ch…

Individual differences in spatial working memory strategies differentially reflected in the engagement of control and default brain networks Open

Nina Purg, Aleksij Kraljič, Masih Rahmati, Youngsun Cho, Anka Slana Ozimič , et al. · 2023

Spatial locations can be encoded and maintained in working memory using different representations and strategies. Fine-grained representations provide detailed stimulus information, but are cognitively demanding and prone to inexactness. T…

Mnemonic representations in human lateral geniculate nucleus Open

Masih Rahmati, Clayton E. Curtis, Kartik K. Sreenivasan · 2023

There is a growing appreciation for the role of the thalamus in high-level cognition. Motivated by findings that internal cognitive state drives activity in feedback layers of primary visual cortex (V1) that target the lateral geniculate n…

Ketamine induces multiple individually distinct whole-brain functional connectivity signatures Open

Flora Moujaes, Jie Lisa Ji, Masih Rahmati, Joshua B. Burt, Charles Schleifer , et al. · 2022

Background Ketamine has emerged as one of the most promising therapies for treatment-resistant depression. However, inter-individual variability in response to ketamine is still not well understood and it is unclear how ketamine’s molecula…

Behavioral Prioritization Enhances Working Memory Precision and Neural Population Gain Open

Aspen H. Yoo, Alfredo Bolaños, Grace E. Hallenbeck, Masih Rahmati, Thomas C. Sprague , et al. · 2021

Humans allocate visual working memory (WM) resource according to behavioral relevance, resulting in more precise memories for more important items. Theoretically, items may be maintained by feature-tuned neural populations, where the relat…

Behavioral prioritization enhances working memory precision and neural population gain Open

Aspen H. Yoo, Alfredo Bolaños, Grace E. Hallenbeck, Masih Rahmati, Thomas C. Sprague , et al. · 2021

Humans allocate visual working memory (WM) resource according to behavioral relevance, resulting in more precise memories for more important items. Theoretically, items may be maintained by feature-tuned neural populations, where the relat…

The format of visual working memory representations Open

Yuna Kwak, Masih Rahmati, Clayton E. Curtis · 2021

Working memory (WM) enables us to maintain and manipulate information in the absence of an external stimulus. The contents of visual WM can be decoded from the spatial patterns of neural activity during memory delays across a widely distri…

Working memory representations in visual cortex mediate distraction effects Open

Grace E. Hallenbeck, Thomas C. Sprague, Masih Rahmati, Kartik K. Sreenivasan, Clayton E. Curtis · 2021

Working Memory Representations in Visual Cortex Mediate the Effects of Distraction Open

Grace E. Hallenbeck, Thomas C. Sprague, Masih Rahmati, Kartik K. Sreenivasan, Clayton E. Curtis · 2021

SUMMARY Although the contents of working memory (WM) can be decoded from activity in visual cortex, these representations may play a limited role if they are not robust to distraction. Here, we used model-based fMRI to estimate the impact …

Spatially Specific Working Memory Activity in the Human Superior Colliculus Open

Masih Rahmati, Kevin DeSimone, Clayton E. Curtis, Kartik K. Sreenivasan · 2020

Theoretically, working memory (WM) representations are encoded by population activity of neurons with distributed tuning across the stored feature. Here, we leverage computational neuroimaging approaches to map the topographic organization…

Spatially-specific working memory activity in the human superior colliculus Open

Masih Rahmati, Kevin DeSimone, Clayton E. Curtis, Kartik K. Sreenivasan · 2020

Theoretically, working memory (WM) representations are encoded by population activity of neurons with distributed tuning across the stored feature. Here, we leverage computational neuroimaging approaches to map the topographic organization…

Prioritization affects working memory precision and neural population gain Open

Aspen H. Yoo, Alfredo Bolaños, Grace E. Hallenbeck, Masih Rahmati, Thomas C. Sprague , et al. · 2019

Humans allocate visual working memory (VWM) resource according to behavioral relevance, resulting in more precise memories for more important items (Bays & Husain, 2008; Emrich et al., 2017; Klyszejko et al., 2014; Yoo et al., 2018). Theor…

Prioritizing relevant information in visual working memory sculpts neural representations in retinotopic cortex to reduce their uncertainty Open

Thomas C. Sprague, Aspen H. Yoo, Masih Rahmati, Grace E. Hallenbeck, Wei Ji , et al. · 2019

Increasing visual working memory (WM) load causes a steep decline in recall precision about specific feature values (Wilken & Ma, 2004; Zhang & Luck, 2008; Bays & Husain, 2008), and causes neural representations in visual, parietal, and fr…

The nature of top-down signals during non-spatial working memory Open

Masih Rahmati, Thomas C. Sprague, Kartik K. Sreenivasan, Clayton E. Curtis · 2019

Theoretical models emphasize the importance of top-down signals in the mechanisms that support working memory (WM; Curtis & D’Esposito, 2003; Sreenivasan et al., 2014). Yet, the nature and mechanisms by which top-down signals support WM fu…

Spatial working memory representations are resistant to an intervening stimulus and behavioral task Open

Grace E. Hallenbeck, Thomas C. Sprague, Masih Rahmati, Kartik K. Sreenivasan, Clayton E. Curtis · 2019

A robust working memory (WM) system requires the maintenance of past but relevant information in memory against a continuous flow of newly incoming but irrelevant information. Recent reports conflict on how WM representations encoded in vi…

The role of task-irrelevant space in non-spatial working memory Open

Masih Rahmati, Thomas C. Sprague, Clayton E. Curtis, Kartik K. Sreenivasan · 2018

Previous studies have demonstrated that the contents of visual working memory (WM) can be decoded from the spatial patterns of brain activity in visual cortex (e.g., Serences et al., 2009; Harrison & Tong, 2009; Rahmati et al., 2017). Resu…

Inverted Encoding Models Assay Population-Level Stimulus Representations, Not Single-Unit Neural Tuning Open

Thomas C. Sprague, Kirsten Adam, Joshua J. Foster, Masih Rahmati, David Sutterer , et al. · 2018

Neuroscience methods range astronomically in scale.In some experiments, we record subthreshold membrane potentials in individual neurons, while in others we measure aggregate responses of thousands of neurons at the millimeter scale.A cent…

Population Dynamics of Early Visual Cortex during Working Memory Open

Masih Rahmati, Golbarg Saber, Clayton E. Curtis · 2017

Although the content of working memory (WM) can be decoded from the spatial patterns of brain activity in early visual cortex, how populations encode WM representations remains unclear. Here, we address this limitation by using a model-bas…

Decoding visual spatial working memory uncertainty from human cortex Open

Thomas C. Sprague, Masih Rahmati, Aspen H. Yoo, Wei Ji, Clayton E. Curtis · 2017

Although we have remarkable insight into the variations in quality of our visual working memory (WM) representations (Rademaker et al, 2012), how this uncertainty arises from neural activity patterns remains unknown. Bayesian theories of p…

Reconstructing the population dynamics of spatial priority in early visual cortex during working memory Open

Masih Rahmati, Golbarg Saber, Clayton E. Curtis · 2015

The read-out of prioritized maps of space in frontal cortex is believed to provide the spatial feedback signals needed to bias activity in early visual cortex. These feedback signals can be spatially directed via a saccade plan. Maintainin…

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