Mason Jager
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View article: Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families
Broad-spectrum synthetic carbohydrate receptors (SCRs) inhibit viral entry across multiple virus families Open
Viral pandemics continue to threaten global health and economic stability. Despite medical advances, the absence of broad-spectrum antivirals (BSAs) prevents rapid responses to emerging viral threats. This is largely due to the lack of uni…
View article: Myofibroblast differentiation in a cat with eosinophilic sclerosing fibroplasia involving mesenteric lymph nodes and liver
Myofibroblast differentiation in a cat with eosinophilic sclerosing fibroplasia involving mesenteric lymph nodes and liver Open
Feline eosinophilic sclerosing fibroplasia (FESF) is a unique fibroproliferative disease of cats marked by eosinophilic inflammation and extensive tissue fibroplasia that affects the gastrointestinal tract predominantly. Biopsy specimens w…
View article: Footprint-free induced pluripotent stem cells can be successfully differentiated into mesenchymal stromal cells in the feline model
Footprint-free induced pluripotent stem cells can be successfully differentiated into mesenchymal stromal cells in the feline model Open
We demonstrated the generation of footprint-free iPSCs from domestic cats and their directed differentiation potential towards MSCs. These SeV-derived feline iPSCs and iPSC-derived MSCs will provide valuable models to study feline diseases…
View article: Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 Virulence
Deletion of a KSF Motif Attenuates NSP1 Host Cell Translation Shutoff and Impairs SARS-CoV-2 Virulence Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of coronavirus disease 2019 (COVID-19), triggered a global pandemic with profound social and economic consequences. The viral spike (S) protein has been iden…
View article: Replication-incompetent VSV-based vaccine elicits protective responses against SARS-CoV-2 and influenza virus
Replication-incompetent VSV-based vaccine elicits protective responses against SARS-CoV-2 and influenza virus Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza viruses lead to severe respiratory illnesses and death in humans, exacerbated in individuals with underlying health conditions, remaining substantial global public …
View article: Chronic oral dosing of cannabidiol and cannabidiolic acid full-spectrum hemp oil extracts has no adverse effects in horses: a pharmacokinetic and safety study
Chronic oral dosing of cannabidiol and cannabidiolic acid full-spectrum hemp oil extracts has no adverse effects in horses: a pharmacokinetic and safety study Open
OBJECTIVE To compare the pharmacokinetics of cannabidiol (CBD) and cannabidiolic acid (CBDA) in horses and to evaluate the safety of their chronic administration. METHODS CBD- and CBDA-rich oil (1 mg/kg) were administered orally twice dail…
View article: Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs
Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2-infected older mice with neurological signs Open
COVID-19 can cause neurological symptoms such as fever, dizziness, and nausea. However, such neurological symptoms of SARS-CoV-2 infection have been hardly assessed in mouse models. In this study, we infected two commonly used wild-type mo…
View article: Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection
Neonatal CD8+ T Cells Resist Exhaustion during Chronic Infection Open
Chronic viral infections, such as HIV and hepatitis C virus, represent a major public health problem. Although it is well understood that neonates and adults respond differently to chronic viral infections, the underlying mechanisms remain…
View article: Optic nerve meningioma and cloacal adenocarcinoma in a Humboldt penguin
Optic nerve meningioma and cloacal adenocarcinoma in a Humboldt penguin Open
A 26-y-old, male, captive Humboldt penguin ( Spheniscus humboldti) was euthanized following a 3.5-mo history of weakened elimination mechanics, recurrent tenesmus, intermittent hemorrhagic droppings, and a cloacal mass. Blepharospasm, of u…
View article: Adaptive immune cells are necessary for SARS-CoV-2–induced pathology
Adaptive immune cells are necessary for SARS-CoV-2–induced pathology Open
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is causing the ongoing global pandemic associated with morbidity and mortality in humans. Although disease severity correlates with immune dysregulation, the cellular mechanisms …
View article: Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses
Naturally acquired equine parvovirus-hepatitis is associated with a wide range of hepatic lesions in horses Open
Equine parvovirus-hepatitis (EqPV-H) is the causative agent of Theiler’s disease, or severe acute hepatic necrosis, in horses. However, it is poorly understood whether EqPV-H is associated with other histologic findings in horses with clin…
View article: Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2 infected older mice with neurological signs
Migraine inhibitor olcegepant reduces weight loss and IL-6 release in SARS-CoV-2 infected older mice with neurological signs Open
COVID-19 can result in neurological symptoms such as fever, headache, dizziness, and nausea. However, neurological signs of SARS-CoV-2 infection have been hardly assessed in mouse models. Here, we infected two commonly used wildtype mice l…
View article: Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA.5
Age-dependent acquisition of pathogenicity by SARS-CoV-2 Omicron BA.5 Open
Pathology studies of SARS-CoV-2 Omicron variants of concern (VOC) are challenged by the lack of pathogenic animal models. While Omicron BA.1 and BA.2 replicate in K18-hACE2 transgenic mice, they cause minimal to negligible morbidity and mo…
View article: Tropism, pathology, and transmission of equine parvovirus-hepatitis
Tropism, pathology, and transmission of equine parvovirus-hepatitis Open
Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause of Theiler's disease, we first demonstrated hepatotrop…
View article: Prevalence and pathology of equine parvovirus-hepatitis in racehorses from New York racetracks
Prevalence and pathology of equine parvovirus-hepatitis in racehorses from New York racetracks Open
Background Theiler’s disease, a.k.a. equine serum hepatitis, is a devastating, highly fatal disease of horses. Equine parvovirus-hepatitis (EqPV-H) has been identified as the likely cause of this disease. While the incidence of Theiler’s d…
View article: New Class of Broad-Spectrum Antivirals Improves Influenza Virus Vaccine Development
New Class of Broad-Spectrum Antivirals Improves Influenza Virus Vaccine Development Open
Enveloped viruses can cause devastating zoonotic diseases and are the most likely to cause global pandemics. We identified a new class of small-molecule sulfur-containing antiviral compounds (XM series) that broadly inhibit enveloped virus…
View article: Small but mighty: old and new parvoviruses of veterinary significance
Small but mighty: old and new parvoviruses of veterinary significance Open
In line with the Latin expression “ sed parva forti” meaning “small but mighty,” the family Parvoviridae contains many of the smallest known viruses, some of which result in fatal or debilitating infections. In recent years, advances in me…
View article: Headless Henipaviral Receptor Binding Glycoproteins Reveal Fusion Modulation by the Head/Stalk Interface and Post-receptor Binding Contributions of the Head Domain
Headless Henipaviral Receptor Binding Glycoproteins Reveal Fusion Modulation by the Head/Stalk Interface and Post-receptor Binding Contributions of the Head Domain Open
The Henipavirus genus in the Paramyxoviridae family includes the zoonotic Nipah (NiV) and Hendra (HeV) viruses. NiV and HeV infections often cause fatal encephalitis and pneumonia, but no vaccines or therapeutics are currently approved for…
View article: A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice
A novel highly potent inhibitor of TMPRSS2-like proteases blocks SARS-CoV-2 variants of concern and is broadly protective against infection and mortality in mice Open
Summary The COVID-19 pandemic caused by the SARS-CoV-2 virus remains a global public health crisis. Although widespread vaccination campaigns are underway, their efficacy is reduced against emerging variants of concern (VOCs) 1,2 . Develop…
View article: Tropism, pathology, and transmission of equine parvovirus-hepatitis
Tropism, pathology, and transmission of equine parvovirus-hepatitis Open
Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause of Theiler's disease, we first demonstrated hepatotrop…
View article: First report of equine parvovirus‐hepatitis‐associated Theiler’s disease in Europe
First report of equine parvovirus‐hepatitis‐associated Theiler’s disease in Europe Open
Background Equine parvovirus‐hepatitis (EqPV‐H) has been proposed as the aetiological cause of Theiler's disease, also known as serum hepatitis. EqPV‐H‐associated Theiler's disease has not been previously reported in Europe. Objectives To …
View article: Tropism, pathology, and transmission of equine parvovirus-hepatitis
Tropism, pathology, and transmission of equine parvovirus-hepatitis Open
Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause of Theiler's disease, we first demonstrated hepatotrop…
View article: Tropism, pathology, and transmission of equine parvovirus-hepatitis
Tropism, pathology, and transmission of equine parvovirus-hepatitis Open
Equine parvovirus-hepatitis (EqPV-H) has recently been associated with cases of Theiler's disease, a form of fulminant hepatic necrosis in horses. To assess whether EqPV-H is the cause of Theiler's disease, we first demonstrated hepatotrop…