Masoomeh Dadkhah
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View article: Non-pharmacological therapeutic paradigms in stress-induced depression: from novel therapeutic perspective with focus on cell-based strategies
Non-pharmacological therapeutic paradigms in stress-induced depression: from novel therapeutic perspective with focus on cell-based strategies Open
Major depressive disorder (MDD) is considered a psychiatric disorder and have a relationship with stressful events. Although the common therapeutic approaches against MDD are diverse, a large number of patients do not present an adequate r…
View article: Insights on Benzodiazepine’s Contribution to Neuroinflammation and Alzheimer’s Disease Biomarkers
Insights on Benzodiazepine’s Contribution to Neuroinflammation and Alzheimer’s Disease Biomarkers Open
Benzodiazepines (BZDs) are a class of prescription medications widely used for their anxiolytic, hypnotic, and muscle relaxant properties. Prolonged use of BZDs has been shown to increase the risk of abuse, dependence, and relapse in patie…
View article: Pegylated chitosan nanoparticles of fluoxetine enhance cognitive performance and hippocampal brain derived neurotrophic factor levels in a rat model of local demyelination
Pegylated chitosan nanoparticles of fluoxetine enhance cognitive performance and hippocampal brain derived neurotrophic factor levels in a rat model of local demyelination Open
Cognitive impairment is a common feature in neurodegenerative diseases such as multiple sclerosis (MS). This study aims to explore the potential of enhancing the beneficial effects of fluoxetine (FLX), a neuroprotective agent known for its…
View article: Quercetin ameliorates cognitive deficit, expression of amyloid precursor gene, and pro-inflammatory cytokines in an experimental models of Alzheimer's disease in Wistar rats
Quercetin ameliorates cognitive deficit, expression of amyloid precursor gene, and pro-inflammatory cytokines in an experimental models of Alzheimer's disease in Wistar rats Open
Chronic stress (CS) is critically involved in the Alzheimer's disease (AD) pathogenesis resulting in cognitive disturbance. Also, amyloid precursor protein (APP) related gens, pro-inflammatory cytokines, and stress increases AD-related pat…
View article: BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis
BDNF/CREB signaling pathway contribution in depression pathogenesis: A survey on the non-pharmacological therapeutic opportunities for gut microbiota dysbiosis Open
Emerging evidence supports the gut microbiota and the brain communication in general health. This axis may affect behavior through modulating neurotransmission, and thereby involve in the pathogenesis and/or progression of different neurop…
View article: Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats
Persistent diazinon induced neurotoxicity: The effect on inhibitory avoidance memory performance, amyloid precursor proteins, and TNF-α levels in the prefrontal cortex of rats Open
Introduction Organophosphate pesticides (Ops) like diazinon (DZN) have well-known neurotoxic effects and low-level chronic exposure has been linked to detrimental neurobehavioral impairments and memory deficits. However, it’s not entirely …
View article: Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii-infected rat model of ketamine-induced schizophrenia
Berberine improves inhibitory avoidance memory impairment of Toxoplasma gondii-infected rat model of ketamine-induced schizophrenia Open
Background Memory impairment caused by Toxoplasma gondii infection has been documented. Berberine (BRB) is well known for its enhancing effects on memory and has shown promising results. However, the impact of BRB on T. gondii infection an…
View article: Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy
Experimental and clinical evidence of physical exercise on BDNF and cognitive function: A comprehensive review from molecular basis to therapy Open
Understanding how physical exercise (PE) can influence brain function, especially cognition, through the modulatory effects of brain-derived neurotrophic factor (BDNF) has been extensively studied over the past few decades. Several studies…
View article: Hypothalamus and Post-Traumatic Stress Disorder: A Review
Hypothalamus and Post-Traumatic Stress Disorder: A Review Open
Humans have lived in a dynamic environment fraught with potential dangers for thousands of years. While fear and stress were crucial for the survival of our ancestors, today, they are mostly considered harmful factors, threatening both our…
View article: Sub-chronic exposure to diazinon induce cognitive impairment, alternations in amyloid precursor proteins, and TNF-α expression in the hippocampus of adult rats
Sub-chronic exposure to diazinon induce cognitive impairment, alternations in amyloid precursor proteins, and TNF-α expression in the hippocampus of adult rats Open
Organophosphate pesticides such as diazinon (DZN) are involved in the development of psychological symptoms and memory deficits but their effects on the amyloid precursor proteins (APP) genes expression remains unclear. Following low-level…
View article: Anesthesia and analgesia for common research models of adult mice
Anesthesia and analgesia for common research models of adult mice Open
View article: Exosome-based strategies for diagnosis and therapy of glioma cancer
Exosome-based strategies for diagnosis and therapy of glioma cancer Open
View article: Hematological Parameters as Diagnostic Factors: Correlation with Severity of COVID-19.
Hematological Parameters as Diagnostic Factors: Correlation with Severity of COVID-19. Open
Elevated NLR can be assumed as an independent biomarker, which could provide a crucial indicator in the monitoring patients with COVID-19 on admission. Increased NLR was correlated with the severity of COVID-19. Assessment of NLR could be …
View article: Role of Amygdala-Infralimbic Cortex Circuitry in Glucocorticoid-induced Facilitation of Auditory Fear Memory Extinction
Role of Amygdala-Infralimbic Cortex Circuitry in Glucocorticoid-induced Facilitation of Auditory Fear Memory Extinction Open
Introduction: The basolateral amygdala (BLA) and infralimbic area (IL) of the medial prefrontal cortex (mPFC) are two interconnected brain structures that mediate both fear memory expression and extinction. Besides the well-known role of t…
View article: COVID-19 and Hydatidosis Infections: Is There Any Relationship?
COVID-19 and Hydatidosis Infections: Is There Any Relationship? Open
The article's abstract is not available.
View article: Therapeutic effects of environmental enrichment against chronic stress-induced cognitive-behavioral impairments: A comprehensive review of recent advances
Therapeutic effects of environmental enrichment against chronic stress-induced cognitive-behavioral impairments: A comprehensive review of recent advances Open
Chronic exposure to stress has been demonstrated to increase the risk of developing neuropsychiatric disorders. Given the importance of effective therapeutic ways to overcome stress-related deficits,the present review focused on the therap…
View article: The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies
The immune response and immune evasion characteristics in SARS-CoV, MERS-CoV, and SARS-CoV-2: Vaccine design strategies Open
View article: Protective Effects of Spirulina platensis, Voluntary Exercise and Environmental Interventions Against Adolescent Stress-Induced Anxiety and Depressive-Like Symptoms, Oxidative Stress and Alterations of BDNF and 5HT-3 Receptors of the Prefrontal Cortex in Female Rats
Protective Effects of Spirulina platensis, Voluntary Exercise and Environmental Interventions Against Adolescent Stress-Induced Anxiety and Depressive-Like Symptoms, Oxidative Stress and Alterations of BDNF and 5HT-3 Receptors of the Prefrontal Cortex in Female Rats Open
Nasroallah Moradi-Kor,1,2 Masoomeh Dadkhah,3 Ali Ghanbari,2 Hadi Rashidipour,4 Ahmad Reza Bandegi,5 Mehdi Barati,6 Parviz Kokhaei,7 Ali Rashidy-Pour2,8 1Student Research Committee, Semnan University of Medical Sciences, Semnan, Iran; 2Rese…