Masoud Delfi
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Stimuli-responsive liposomal nanoformulations in cancer therapy: Pre-clinical & clinical approaches Open
The site-specific delivery of antitumor agents is of importance for providing effective cancer suppression. Poor bioavailability of anticancer compounds and the presence of biological barriers prevent their accumulation in tumor sites. The…
Pre-Clinical and Clinical Applications of Small Interfering RNAs (siRNA) and Co-Delivery Systems for Pancreatic Cancer Therapy Open
Pancreatic cancer (PC) is one of the leading causes of death and is the fourth most malignant tumor in men. The epigenetic and genetic alterations appear to be responsible for development of PC. Small interfering RNA (siRNA) is a powerful …
Crystallization of 3-hexulose-6-phosphate synthase Open
The crystal structures can reveal detailed information about the overall structure, active site structure, and functional mechanism of enzymes. This study focused on the crystallization of 3-hexulose-6-phosphate synthase from Methylomonas …
View article: Striking Dependence of Protein Sweetness on Water Quality: The Role of the Ionic Strength
Striking Dependence of Protein Sweetness on Water Quality: The Role of the Ionic Strength Open
Sweet proteins are the sweetest natural molecules. This aspect prompted several proposals for their use as food additives, mainly because the amounts to be added to food would be very small and safe for people suffering from sucrose-linked…
View article: A Super Stable Mutant of the Plant Protein Monellin Endowed with Enhanced Sweetness
A Super Stable Mutant of the Plant Protein Monellin Endowed with Enhanced Sweetness Open
Sweet proteins are a class of proteins with the ability to elicit a sweet sensation in humans upon interaction with sweet taste receptor T1R2/T1R3. Single-chain Monellin, MNEI, is among the sweetest proteins known and it could replace suga…
Drug Delivery (Nano)Platforms for Oral and Dental Applications: Tissue Regeneration, Infection Control, and Cancer Management Open
The oral cavity and oropharynx are complex environments that are susceptible to physical, chemical, and microbiological insults. They are also common sites for pathological and cancerous changes. The effectiveness of conventional locally‐a…
Functionalization of Polymers and Nanomaterials for Biomedical Applications: Antimicrobial Platforms and Drug Carriers Open
The use of polymers and nanomaterials has vastly grown for industrial and biomedical sectors during last years. Before any designation or selection of polymers and their nanocomposites, it is vital to recognize the targeted applications wh…
View article: Probing structural changes during amyloid aggregation of the sweet protein MNEI
Probing structural changes during amyloid aggregation of the sweet protein MNEI Open
Protein self‐assembly is a ubiquitous phenomenon, traditionally studied for its links to amyloid pathologies, which has also gained attention as its physiological roles and possible biotechnological applications emerged over time. It is al…