Massimo Carollo
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View article: Children’s exposure to cocaine detected by hair analysis: a systematic review and meta-analysis
Children’s exposure to cocaine detected by hair analysis: a systematic review and meta-analysis Open
Background Cocaine is a widespread drug of abuse to which children can also be exposed. The modes of exposure may vary depending on the age of the child. In addition to blood and urine analysis, hair analysis is currently used in some clin…
View article: The challenge of molecular stratification in No Specific Molecular Profile endometrial cancer
The challenge of molecular stratification in No Specific Molecular Profile endometrial cancer Open
These findings underscore the potential of ER loss and L1CAM overexpression as prognostic markers within the NSMP subgroup, supporting more personalized adjuvant strategies. Further research is needed to clarify the prognostic role of othe…
View article: Impact of Disease-Modifying Antirheumatic Drugs on Cognitive Function in Older Adults with Rheumatoid Arthritis
Impact of Disease-Modifying Antirheumatic Drugs on Cognitive Function in Older Adults with Rheumatoid Arthritis Open
Cognitive impairment poses significant challenges for aging populations. Systemic inflammation, a hallmark of rheumatoid arthritis (RA), has been implicated in neurodegeneration through mechanisms including blood-brain barrier disruption, …
View article: Severe Presentation of Cannabinoid Hyperemesis Syndrome With Mixed Acid–Base Disorder and Cardiac Complications: A Case Report
Severe Presentation of Cannabinoid Hyperemesis Syndrome With Mixed Acid–Base Disorder and Cardiac Complications: A Case Report Open
Background: Cannabinoid hyperemesis syndrome (CHS) is a condition characterized by cyclic abdominal pain, vomiting, and nausea, primarily affecting adolescents and adults with a history of chronic cannabis use. The diagnosis of CHS is clin…
View article: Δ-Peritoneal Cancer Index (Δ-PCI) to Predict Complete Cytoreduction and Histopathological Response to Neoadjuvant Chemotherapy in Ovarian Cancer
Δ-Peritoneal Cancer Index (Δ-PCI) to Predict Complete Cytoreduction and Histopathological Response to Neoadjuvant Chemotherapy in Ovarian Cancer Open
Objectives: To analyze the role of PCI variation (Δ-PCI) before and after neoadjuvant chemotherapy (NACT) in an interval cytoreductive surgery (ICS) setting with the aim to propose a scoring model for predicting both complete cytoreduction…
View article: Clinical Utility and Diagnostic Accuracy of ROMA, RMI, ADNEX, HE4, and CA125 in the Prediction of Malignancy in Adnexal Masses
Clinical Utility and Diagnostic Accuracy of ROMA, RMI, ADNEX, HE4, and CA125 in the Prediction of Malignancy in Adnexal Masses Open
Objective: We aimed to compare the clinical utility and diagnostic accuracy of the ADNEX model, ROMA score, RMI I, and RMI IV, as well as two serum markers (CA125 and HE4) in preoperative discrimination between benign and malignant adnexal…
View article: Reversal of dabigatran and apixaban-induced coagulopathy using idarucizumab, fibrinogen, and prothrombin complex concentrate: A case report
Reversal of dabigatran and apixaban-induced coagulopathy using idarucizumab, fibrinogen, and prothrombin complex concentrate: A case report Open
This case report examines the combined use of fibrinogen concentrate, four-factor prothrombin complex concentrate (PCC), and idarucizumab, a specific antidote for dabigatran, to reverse the anticoagulant effects of dabigatran and apixaban-…
View article: Circulating Factors as Potential Biomarkers of Cardiovascular Damage Progression Associated with Type 2 Diabetes
Circulating Factors as Potential Biomarkers of Cardiovascular Damage Progression Associated with Type 2 Diabetes Open
Background: Diabetes, particularly type 2 diabetes (T2D), is linked with an increased risk of developing coronary heart disease (CHD). The present study aimed to evaluate potential circulating biomarkers of CHD by adopting a targeted prote…
View article: Agreement of Different Drug-Drug Interaction Checkers for Proton Pump Inhibitors
Agreement of Different Drug-Drug Interaction Checkers for Proton Pump Inhibitors Open
Importance Proton pump inhibitors (PPIs) are a widely prescribed class of drugs, potentially interacting with a large number of medicines, especially among older patients with multimorbidity and polypharmacy. Beyond summary of product char…
View article: Not only Van Gogh: a case of BRASH syndrome with concomitant digoxin toxicity
Not only Van Gogh: a case of BRASH syndrome with concomitant digoxin toxicity Open
Background Bradycardia, renal failure, atrioventricular (AV) node blocking, shock, and hyperkalemia syndrome is a potentially life-threatening clinical condition characterized by bradycardia, renal failure, atrioventricular (AV) node block…
View article: Clinical impact of medication review and deprescribing in older inpatients: A systematic review and meta‐analysis
Clinical impact of medication review and deprescribing in older inpatients: A systematic review and meta‐analysis Open
Background Polypharmacy is a primary risk factor for the prescription of potentially inappropriate medications (PIMs), drug–drug interactions (DDIs), and ultimately, adverse drug reactions (ADRs). Medication review and deprescribing repres…
View article: Development and Validation of a META-Algorithm to Identify the Indications of Use of Biological Drugs Approved for the Treatment of Immune-Mediated Inflammatory Diseases from Claims Databases: Insights from the VALORE Project
Development and Validation of a META-Algorithm to Identify the Indications of Use of Biological Drugs Approved for the Treatment of Immune-Mediated Inflammatory Diseases from Claims Databases: Insights from the VALORE Project Open
The newly developed META-algorithm demonstrated high validity estimates in the Italian claims data and was capable of discriminating with good performance among the most frequent IMID indications.
View article: Artificial intelligence for optimizing benefits and minimizing risks of pharmacological therapies: challenges and opportunities
Artificial intelligence for optimizing benefits and minimizing risks of pharmacological therapies: challenges and opportunities Open
In recent years, there has been an exponential increase in the generation and accessibility of electronic healthcare data, often referred to as “real-world data”. The landscape of data sources has significantly expanded to encompass tradit…
View article: Gap junction modulators: Prospects in bupropion cardiotoxicity
Gap junction modulators: Prospects in bupropion cardiotoxicity Open
Bupropion, a multifaceted antidepressant, is associated with serious cardiotoxicity when misused. Recently, there has been a noticeable increase in cases of intentional poisoning and current therapeutic interventions for bupropion overdose…
View article: Comparing clinical trial population representativeness to real-world users of 17 biologics approved for immune-mediated inflammatory diseases: An external validity analysis of 66,639 biologic users from the Italian VALORE project
Comparing clinical trial population representativeness to real-world users of 17 biologics approved for immune-mediated inflammatory diseases: An external validity analysis of 66,639 biologic users from the Italian VALORE project Open
To date, no population-based studies have specifically explored the external validity of pivotal randomized clinical trials (RCTs) of biologics simultaneously for a broad spectrum of immuno-mediated inflammatory diseases (IMIDs). The aims …
View article: “Heavy Metal”: Management of lead toxicity following a gunshot injury with retained lead fragments, a case report
“Heavy Metal”: Management of lead toxicity following a gunshot injury with retained lead fragments, a case report Open
There is limited literature on managing chronic lead exposure from non-removable sources such as lead fragments. In this case report, we present the complexities and clinical considerations involved in treating an elderly patient who susta…
View article: The promise of N-Acetylcysteine in the Treatment of Obsessive-Compulsive Disorder
The promise of N-Acetylcysteine in the Treatment of Obsessive-Compulsive Disorder Open
Obsessive-compulsive disorder (OCD) is a challenging psychiatric condition with limited treatment responses to standard therapies like selective serotonin reuptake inhibitors and cognitive-behavioral therapy. This letter to the Editor is i…
View article: Androgens and Female Sexuality: Molecular Insights, Neuroendocrine Crosstalk and Future Therapeutic Directions
Androgens and Female Sexuality: Molecular Insights, Neuroendocrine Crosstalk and Future Therapeutic Directions Open
Objective: The scientific community has recently directed its attention towards investigating the role of androgens in female sexuality. This narrative review aims to elucidate the central and peripheral androgen-mediated mechanisms involv…