Explanipedia

Radiocarbon dating of dental tissues for determining time since death in forensic cases: a systematic review Open

Massimo Lancia, Cristiana Gambelunghe, Lucio Calcagnile, Gianluca Quarta, Marisa D’Elia · 2025

Medico-legal case series of litigation involving chronic post-herniorrhaphy inguinal pain: insights from Italian civil verdicts Open

Roberto Cirocchi, Luca Tomassini, Salvatore Guarino, Andrea Mingoli, Diletta Cassini , et al. · 2025

Chronic Groin Pain After Hernia Surgery: What Are We Missing? Open

Roberto Cirocchi, Paolo Bruzzone, Bruno Cirillo, Sara Lauricella, Gianluca Costa , et al. · 2025

Background: Chronic postoperative inguinal pain [CPIP] is a prevalent and often debilitating complication following inguinal hernia repair. With the widespread adoption of mesh-based techniques, recurrence rates have significantly declined…

Microbial succession after death: genomic and culture-based insights from external sampling sites in forensic science Open

Luca Tomassini, Virginia Goracci, Martina Onofri, Cristiana Gambelunghe, Piergiorgio Fedeli , et al. · 2025

Despite encouraging results, the forensic application of post-mortem microbiome and microbiota remains hindered by methodological inconsistencies and a lack of standardization. Establishing unified protocols and adopting interdisciplinary …

Health Profiles of Inmates: A Cross-Sectional Study of Prevalent Diseases in a Central Italian Prison Open

Massimo Lancia, Luca Tomassini, Roberto Scendoni, Elisa Fanella, Alessio Gili , et al. · 2025

Background: Article 32 of the Italian Constitution guarantees the right to health for all citizens, including detainees. Prison populations face unique health challenges due to high-risk lifestyles, psychosocial stressors, and limited acce…

Beyond the numbers: Critical analysis of the role of postmortem tryptase in the forensic diagnosis of anaphylaxis Open

Luca Tomassini, Giulia Ricchezze, Cristiana Gambelunghe, Massimo Lancia, Marco Gramaccia , et al. · 2025

The postmortem diagnosis of anaphylaxis remains a forensic challenge due to the lack of specific external signs. Tryptase, a mast cell‐derived protease, has emerged as a potential biomarker for fatal anaphylaxis. This systematic review cri…

Chronic Groin Pain After Hernia Surgery: What Are We Missing? Open

Roberto Cirocchi, Paolo Bruzzone, Bruno Cirillo, Sara Lauricella, Gianluca Costa , et al. · 2025

Background: Chronic postoperative inguinal pain [CPIP] is a prevalent and often debili-tating complication following inguinal hernia repair. With the widespread adoption of mesh-based techniques, recurrence rates have declined, shifting cl…

Immunohistochemical insights into hyperthermia-related deaths: a systematic review Open

Luca Tomassini, Giulia Ricchezze, Cristiana Gambelunghe, Massimo Lancia, Virginia Goracci , et al. · 2025

Radiocarbon and bomb pulse dating in the forensic context: A systematic review Open

Chantal Milani, Luca Tomassini, Cristiana Gambelunghe, Niccolò Pini, Lucio Calcagnile , et al. · 2025

Immunohistochemical insights into hypothermia-related deaths: a systematic review Open

Luca Tomassini, Massimo Lancia, Cristiana Gambelunghe, Giulia Ricchezze, Piergiorgio Fedeli , et al. · 2025

The existing literature examined appears fragmented and lacks robust statistical validation. Therefore, there is an evident need for more comprehensive and methodologically rigorous research to develop reliable diagnostic criteria.

Exploring the Nexus of Climate Change and Substance Abuse: A Scoping Review Open

Luca Tomassini, Massimo Lancia, Angela Gambelunghe, Abdellah Zahar, Niccolò Pini , et al. · 2024

Introduction: The increase in average air temperature and multiple extreme weather events, such as heatwaves and droughts, pose significant health risks to humans. This scoping review aims to examine the current state of the existing liter…

Is it time for a guideline on the use of immunohistochemistry in forensic pathology? Open

Massimo Lancia, Mauro Bacci · 2024

The Usefulness of qPCR Data for Sample Pre-Assessment and Interpretation of Genetic Typing Results Open

Martina Onofri, Simona Severini, Federica Tommolini, Massimo Lancia, Cristiana Gambelunghe , et al. · 2024

DNA quantification is a crucial step in the STR typing workflow for human identification purposes. Given the reaction’s nature, qPCR assays may be subjected to the same stochastic effects of traditional PCR for low-input concentrations. Th…

Suicidal decapitation by hanging: A systematic review of the literature and comparison with case reports Open

Luca Tomassini, Cristiana Gambelunghe, Piergiorgio Fedeli, Roberto Scendoni, A. Caruso , et al. · 2024

New Insights on Molecular Autopsy in Sudden Death: A Systematic Review Open

Luca Tomassini, Giulia Ricchezze, Piergiorgio Fedeli, Massimo Lancia, Cristiana Gambelunghe , et al. · 2024

Sudden unexpected deaths often remain unresolved despite forensic examination, posing challenges for pathologists. Molecular autopsy, through genetic testing, can reveal hidden causes undetectable by standard methods. This review assesses …

Trace DNA Transfer in Co-Working Spaces: The Importance of Background DNA Analysis Open

Martina Onofri, Federica Tommolini, Simona Severini, Cristiana Gambelunghe, Massimo Lancia , et al. · 2024

The presence of background DNA (bgDNA) can hinder the evaluation of DNA evidence at the activity level, especially when the suspect is expected to be retrieved due to their habitual occupation of the investigated environment. Based on real…

Dating Skin Lesions of Forensic Interest by Immunohistochemistry and Immunofluorescence Techniques: A Scoping Literature Review Open

Luca Tomassini, Massimo Lancia, Roberto Scendoni, Anna Maria Manta, Daniela Fruttini , et al. · 2024

Wound age estimation is a significant issue in forensic pathology. Although various methods have been evaluated, no gold standard system or model has been proposed, and accurate injury time estimation is still challenging. The distinction …

Long-Term Impacts of the COVID-19 Pandemic on Drug/Alcohol Use Prevalence in a Population with Substance Use Disorders Open

Alessio Gili, Massimo Lancia, Angela Gambelunghe, Luca Tomassini, Alessia Nicoletti , et al. · 2023

As time passes, the long-term effects of the COVID-19 pandemic are becoming increasingly apparent. The extreme restrictions imposed during the pandemic have had detrimental impacts on the most vulnerable groups, such as individuals sufferi…

Direct and Secondary Transfer of Touch DNA on a Credit Card: Evidence Evaluation Given Activity Level Propositions and Application of Bayesian Networks Open

Martina Onofri, Cristina Altomare, Simona Severini, Federica Tommolini, Massimo Lancia , et al. · 2023

In a judiciary setting, questions regarding the mechanisms of transfer, persistence, and recovery of DNA are increasingly more common. The forensic expert is now asked to evaluate the strength of DNA trace evidence at activity level, thus …

Patterns of Prescription Medicine, Illicit Drugs, and Alcohol Misuse among High-Risk Population: A Factor Analysis to Delineate Profiles of Polydrug Users Open

Alessio Gili, Massimo Lancia, Isabella Mercurio, Mauro Bacci, Alessia Nicoletti , et al. · 2022

Polydrug use is a serious health and social problem worldwide. Treatment remains a challenge because it requires planning based on estimates of the nature and extent of drug consumption and the characteristics of the population in need. To…

Injuries during Laparoscopic Cholecystectomy: A Scoping Review of the Claims and Civil Action Judgements Open

Roberto Cirocchi, Laura Panata, Ewen A. Griffiths, Giovanni Domenico Tebala, Massimo Lancia , et al. · 2021

Background. To define what type of injuries are more frequently related to medicolegal claims and civil action judgments. Methods. We performed a scoping review on 14 studies and 2406 patients, analyzing medicolegal claims related to lapar…

Dermatome Mapping Test in the analysis of anatomo-clinical correlations after inguinal hernia repair Open

Roberto Cirocchi, Isabella Mercurio, Claudio Nazzaro, Angelo De Sol, Carlo Boselli , et al. · 2020

Toxicological findings in fatal intoxications from synthetic cathinones: a narrative review Open

Isabella Mercurio, Adriana Pellegrino, Laura Panata, Francesca Filippucci, Paola Melai , et al. · 2020

Since description of autopsy findings and an indication of fatal concentrations related to overdoses from synthetic cathinones are rare, we reviewed the literature using three different search engines including articles from 2010 to 2019. …

La morte in carcere conseguente all'inalazione di gas: la responsabilità dello psichiatra. Open

Sara Gioia, Fabio Suadoni, Luigi Carlini, Massimo Lancia · 2020

In ambito penitenziario il suicidio e l'autolesionismo rappresentano quasi una caratteristica strutturale, rendendo la prevenzione un obiettivo primario. L'Amministrazione penitenziaria ha emanato in materia di prevenzione del suicidio un …

A unique autopsy case of spontaneous necrotizing soft tissue infection of the chest-wall in a healthy adult without major risk factors Open

Fabio Suadoni, Sara Gioia, Beatrice Tiri, Antonella Mencacci, Simona Vento , et al. · 2020

Perirectal Hematoma and Intra-Abdominal Bleeding after Stapled Hemorrhoidopexy and STARR—A Proposal for a Decision-Making Algorithm Open

Georgi Popivanov, Piergiorgio Fedeli, Roberto Cirocchi, Massimo Lancia, Domenico Mascagni , et al. · 2020

Background and Objectives: The present study aims to assess the effectiveness and current evidence of the treatment of perirectal bleeding after stapled haemorrhoidopexy. Materials and methods: A systematic literature review was performed …

A New System for Assessing Visual Disability Using a Digital Visor Open

R Sangiuolo, Filippo Amore, Mauro Bacci, Paolo Brusini, Filippo Cruciani , et al. · 2020

Background: Considering the lack of universally accepted visual requirements for driving and for defining various grades of visual disability, the aim of this study is to propose a new method that provides a numerical score resulting from …

Pregabalin Abuse in Combination With Other Drugs: Monitoring Among Methadone Patients Open

Massimo Lancia, Angela Gambelunghe, Alessio Gili, Mauro Bacci, Kyriaki Aroni , et al. · 2020

Most of the patients taking PGB (57.14%) used other drugs (especially opiates) concurrently. The utility of hair analysis is explained by easy and rapid sample collection and the ability of the hair to reflect long-term drug use and incorp…

Media-Based Research on Selfie-Related Deaths in Italy Open

Sara Gioia, Dora Mirtella, Lisa Franceschetto, Massimo Lancia, Fabio Suadoni , et al. · 2019

Background The incidence of taking selfies and sharing them on social media as well as selfie-related dangerous behaviors is increasing, particularly among young people, also leading to selfie-related trauma and death. This study was perfo…

A case of a head-down position death in a six-months old baby with concurrent pneumonia Open

Sara Gioia, Lisa Franceschetto, Luigi Carlini, Fabio Suadoni, Massimo Lancia · 2019

Dying in a head-down position is a not so common occurrence, and the cause of death may not be immediately clear by the results of the autopsy. The authors describe a case of a six-months-old baby, previously healthy and asymptomatic, foun…

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