Massimo Levrero
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View article: Circulating HBV RNA and hepatitis B core-related antigen as determinants of HBsAg loss in persons with HIV in Europe
Circulating HBV RNA and hepatitis B core-related antigen as determinants of HBsAg loss in persons with HIV in Europe Open
View article: HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype
HBV-driven host chromatin accessibility changes affect liver metabolic pathways, iron homeostasis and promote a preneoplastic phenotype Open
View article: Structure and nucleic acid interactions of the S <sup>Δ60</sup> domain of the hepatitis delta virus small antigen
Structure and nucleic acid interactions of the S <sup>Δ60</sup> domain of the hepatitis delta virus small antigen Open
Infection with hepatitis delta virus (HDV) causes the most severe form of viral hepatitis, affecting more than 15 million people worldwide. HDV is a small RNA satellite virus of the hepatitis B virus (HBV) that relies on the HBV envelope f…
View article: Screening for metabolic dysfunction-associated steatotic liver disease related advanced fibrosis in diabetology: a prospective multi-center study.
Screening for metabolic dysfunction-associated steatotic liver disease related advanced fibrosis in diabetology: a prospective multi-center study. Open
Objective: Screening for advanced fibrosis (AF) due to metabolic dysfunction-associated steatotic liver disease (MASLD) is recommended in diabetology. This study aimed to compare the performance of non-invasive tests (NITs) and 2-st…
View article: Screening for metabolic dysfunction-associated steatotic liver disease related advanced fibrosis in diabetology: a prospective multi-center study.
Screening for metabolic dysfunction-associated steatotic liver disease related advanced fibrosis in diabetology: a prospective multi-center study. Open
Objective: Screening for advanced fibrosis (AF) due to metabolic dysfunction-associated steatotic liver disease (MASLD) is recommended in diabetology. This study aimed to compare the performance of non-invasive tests (NITs) and 2-st…
View article: Simultaneous Activation of Beta‐Oxidation and De Novo Lipogenesis in <scp>MASLD</scp>‐<scp>HCC</scp>: A New Paradigm
Simultaneous Activation of Beta‐Oxidation and De Novo Lipogenesis in <span>MASLD</span>‐<span>HCC</span>: A New Paradigm Open
Background and Aims Metabolic dysfunction‐associated steatotic liver disease (MASLD) is the most common cause of hepatocellular carcinoma (HCC). In this study, we combine metabolomic and gene expression analysis to compare HCC tissues with…
View article: Protocol for isolating CD163+ Kupffer cells from human liver resections
Protocol for isolating CD163+ Kupffer cells from human liver resections Open
View article: Bolero: a dedicated workflow to decipher Hepatitis B virus transcriptome from long-reads sequencing method coupled to 5’RACE amplification of transcripts
Bolero: a dedicated workflow to decipher Hepatitis B virus transcriptome from long-reads sequencing method coupled to 5’RACE amplification of transcripts Open
Hepatitis B virus (HBV) represents a major health burden, as it affects close to 290 million people worldwide. Although prophylactic vaccines are available, current therapeutic compounds do not usually achieve HBV eradication due to the pe…
View article: HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx
HBV-related HCC development in mice is STAT3 dependent and indicates an oncogenic effect of HBx Open
View article: A molecular standard for circulating HBV RNA detection and quantification assays in patients with chronic hepatitis B
A molecular standard for circulating HBV RNA detection and quantification assays in patients with chronic hepatitis B Open
View article: The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with <scp>MASLD</scp>
The grade of obesity affects the noninvasive diagnosis of advanced fibrosis in individuals with <span>MASLD</span> Open
Objective Metabolic dysfunction‐associated steatotic liver disease (MASLD) is closely associated with obesity. We aimed to assess the impact of obesity on the performance of different noninvasive tests, including liver stiffness measuremen…
View article: TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism
TLR8 agonist selgantolimod regulates Kupffer cell differentiation status and impairs HBV entry into hepatocytes via an IL-6-dependent mechanism Open
Objective Achieving HBV cure will require novel combination therapies of direct-acting antivirals and immunomodulatory agents. In this context, the toll-like receptor 8 (TLR8) agonist selgantolimod (SLGN) has been investigated in preclinic…
View article: Circulating HBV RNA and Hepatitis B Core–Related Antigen Trajectories in Persons With HIV/HBV Coinfection and Hepatitis B Surface Antigen Loss During Tenofovir Therapy
Circulating HBV RNA and Hepatitis B Core–Related Antigen Trajectories in Persons With HIV/HBV Coinfection and Hepatitis B Surface Antigen Loss During Tenofovir Therapy Open
Background We evaluated long-term trajectories of circulating hepatitis B virus (HBV) RNA and hepatitis B core–related antigen (HBcrAg) in persons with and without hepatitis B surface antigen (HBsAg) loss during tenofovir therapy in the Sw…
View article: miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes
miRNA-27a-3p is involved in the plasticity of differentiated hepatocytes Open
Modulation of H3K27me3 methylation in differentiated HepaRG cells, by GSK-J4 treatment, influenced miRNA' s expression profile pushing liver cells towards a proliferating phenotype. We demonstrated the involvement of miR-27a-3p in reinduci…
View article: Author Correction: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities
Author Correction: Metformin-induced ablation of microRNA 21-5p releases Sestrin-1 and CAB39L antitumoral activities Open
View article: Combination of heterozygous <scp><i>APOB</i></scp> gene mutation with <scp><i>PNPLA3</i></scp> and <scp><i>TM6SF2</i></scp> variants promotes steatotic liver disease, cirrhosis and <scp>HCC</scp> development
Combination of heterozygous <span><i>APOB</i></span> gene mutation with <span><i>PNPLA3</i></span> and <span><i>TM6SF2</i></span> variants promotes steatotic liver disease, cirrhosis and <span>HCC</span> development Open
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View article: Single-cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity
Single-cell landscape of functionally cured chronic hepatitis B patients reveals activation of innate and altered CD4-CTL-driven adaptive immunity Open
View article: RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis
RNA helicase DDX5 modulates sorafenib sensitivity in hepatocellular carcinoma via the Wnt/β-catenin–ferroptosis axis Open
Reduced expression of the RNA helicase DDX5 associated with increased hepatocellular carcinoma (HCC) tumor grade and poor patient survival following treatment with sorafenib. While immunotherapy is the first-line treatment for HCC, sorafen…
View article: Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B
Quantification of circulating HBV RNA expressed from intrahepatic cccDNA in untreated and NUC treated patients with chronic hepatitis B Open
Objective A convenient, reproducible biomarker of hepatitis B virus (HBV) covalently closed circular DNA (cccDNA) transcriptional activity is lacking. We measured circulating HBV RNA (cirB-RNA) in untreated and nucleos(t)ide analogues (NUC…
View article: Long‐term quantitative hepatitis B surface antigen <scp>(HBsAg</scp>) trajectories in persons with and without <scp>HBsAg</scp> loss on tenofovir‐containing antiretroviral therapy
Long‐term quantitative hepatitis B surface antigen <span>(HBsAg</span>) trajectories in persons with and without <span>HBsAg</span> loss on tenofovir‐containing antiretroviral therapy Open
Objectives Improving the understanding of the patterns of quantitative hepatitis B surface antigen (qHBsAg) trajectories associated with HBsAg loss is important in light of novel anti‐hepatitis B virus agents being developed. We evaluated …
View article: Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis
Circulating microRNAs improve bacterial infection diagnosis and overall survival prediction in acute decompensation of liver cirrhosis Open
View article: Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids
Interrogating colorectal cancer metastasis to liver: a search for clinically viable compounds and mechanistic insights in colorectal cancer Patient Derived Organoids Open
View article: Evaluation of the HBV liver reservoir with fine needle aspirates
Evaluation of the HBV liver reservoir with fine needle aspirates Open
View article: Comparison of Pathway Referrals for Liver Fibrosis Risk Stratification Performed in Diabetology and Nutrition Clinics
Comparison of Pathway Referrals for Liver Fibrosis Risk Stratification Performed in Diabetology and Nutrition Clinics Open
A pathway-referral using TE performed in diabetology and nutrition clinics, significantly improves the liver fibrosis risk stratification and avoids over-referral. However, collaboration between diabetologist, nutritionists and hepatologis…
View article: Supplementary Figure 2 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
Supplementary Figure 2 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes Open
Supplementary Figure 2 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
View article: Supplementary Figure 2 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
Supplementary Figure 2 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes Open
Supplementary Figure 2 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
View article: Supplementary Figure 1 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
Supplementary Figure 1 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes Open
Supplementary Figure 1 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
View article: Data from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
Data from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes Open
Despite extensive studies on the role of tumor suppressor p53 protein and its homologues, p73 and p63, following their overexpression or cellular stress, very little is known about the regulation of the three proteins in cells during physi…
View article: Supplementary Figure 5 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
Supplementary Figure 5 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes Open
Supplementary Figure 5 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
View article: Supplementary Figure 1 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes
Supplementary Figure 1 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes Open
Supplementary Figure 1 from p73 and p63 Sustain Cellular Growth by Transcriptional Activation of Cell Cycle Progression Genes