Massimo Mangiola
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View article: Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System
Characterizing the Immune Response in Pig-to-human Heart Xenografts Using a Multimodal Diagnostic System Open
Background: Porcine genome editing has revolutionized xenotransplantation, recently enabling the first pig-to-human heart xenotransplants. However, the xeno-immune response in heart xenografts remains largely unexplored. This study aimed t…
View article: Exploratory Biomarkers for Acute Rejection in Vascularized Composite Allotransplantation
Exploratory Biomarkers for Acute Rejection in Vascularized Composite Allotransplantation Open
Vascularized composite allotransplantation (VCA) involves immunologically heterogeneous tissues and is associated with high rates of acute rejection (AR), particularly due to the immunogenicity of the skin. This study assessed biomarkers t…
View article: Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts
Impact of HLA evolutionary divergence and donor-recipient molecular mismatches on antibody-mediated rejection of kidney allografts Open
View article: Swine Xenografts Share Few Predicted Indirectly Recognisable <scp>SLA</scp>‐Derived Epitopes With <scp>HLA</scp>‐Derived Epitopes From Human Kidney Grafts
Swine Xenografts Share Few Predicted Indirectly Recognisable <span>SLA</span>‐Derived Epitopes With <span>HLA</span>‐Derived Epitopes From Human Kidney Grafts Open
Swine‐derived kidneys are a promising alternative organ source for transplantation, but compatibility in the major histocompatibility complex remains an immunological barrier. Furthermore, in repeat transplantations, CD4+ memory T cells ca…
View article: New Paradigms in Rejection Monitoring: Lymphocyte Subsets as Noninvasive Graft Markers in Vascularized Composite Allotransplantation
New Paradigms in Rejection Monitoring: Lymphocyte Subsets as Noninvasive Graft Markers in Vascularized Composite Allotransplantation Open
Background: In vascularized composite allotransplantation, face transplantation stands as a transformative intervention for patients with severe facial disfigurement. Monitoring of graft rejection, however, remains a critical challenge. Th…
View article: Clinical Outcomes and Donor-specific Antibody Rebound 5 y After Kidney Transplant Enabled by Imlifidase Desensitization
Clinical Outcomes and Donor-specific Antibody Rebound 5 y After Kidney Transplant Enabled by Imlifidase Desensitization Open
Background. Imlifidase is an IgG-cleaving endopeptidase conditionally approved in Europe for desensitization of highly sensitized patients before kidney transplantation. We present 5-y outcomes and donor-specific antibody (DSA) levels for …
View article: Improving long-term kidney allograft survival by rethinking HLA compatibility: from molecular matching to non-HLA genes
Improving long-term kidney allograft survival by rethinking HLA compatibility: from molecular matching to non-HLA genes Open
Optimizing immunologic compatibility in organ transplantation extends beyond the conventional approach of Human Leukocyte Antigen (HLA) antigen matching, which exhibits significant limitations. A broader comprehension of the roles of class…
View article: Balancing Equity and HLA Matching in Deceased-Donor Kidney Allocation with Eplet Mismatch
Balancing Equity and HLA Matching in Deceased-Donor Kidney Allocation with Eplet Mismatch Open
Background Prioritization of HLA antigen-level matching in the US kidney allocation system intends to improve post-transplant survival but causes racial disparities and thus has been substantially de-emphasized. Recently, molecular matchin…
View article: Cellular dynamics in pig-to-human kidney xenotransplantation
Cellular dynamics in pig-to-human kidney xenotransplantation Open
View article: D79. Reports of the Immunologic Management of the World’S First Successful Combined Face and Whole-eye Transplant
D79. Reports of the Immunologic Management of the World’S First Successful Combined Face and Whole-eye Transplant Open
PURPOSE: Previous attempts at whole eye transplantation (WET) were ultimately deemed unsuccessful due to both technical and immunologic limitations. Since the first face transplant (FT) in 2005, significant strides have been made in our un…
View article: D43. New Paradigms in Rejection Monitoring: Lymphocyte Subsets as Non-invasive Graft Markers in Face Transplantation
D43. New Paradigms in Rejection Monitoring: Lymphocyte Subsets as Non-invasive Graft Markers in Face Transplantation Open
PURPOSE: In the evolving field of vascularized composite allotransplantation (VCA), face transplantation stands as a transformative intervention for disfigured patients. Monitoring of graft rejection, however, remains a critical challenge.…
View article: Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts
Biologically derived epicardial patch induces macrophage mediated pathophysiologic repair in chronically infarcted swine hearts Open
View article: The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts
The Banff 2022 Kidney Meeting Work Plan: Data-driven refinement of the Banff Classification for renal allografts Open
The XVIth Banff Meeting for Allograft Pathology was held in Banff, Alberta, Canada, from September 19 to 23, 2022, as a joint meeting with the Canadian Society of Transplantation. In addition to a key focus on the impact of microvascular i…
View article: O16 Toward a combined DR+DQ HLA molecular mismatch score for risk stratification of pediatric heart transplant patients
O16 Toward a combined DR+DQ HLA molecular mismatch score for risk stratification of pediatric heart transplant patients Open
View article: Specificity of <scp>HLA</scp> monoclonal antibodies and their use to determine <scp>HLA</scp> expression on lymphocytes and peripheral blood stem cells
Specificity of <span>HLA</span> monoclonal antibodies and their use to determine <span>HLA</span> expression on lymphocytes and peripheral blood stem cells Open
HLA Class I and II expression are known to differ locus‐to‐locus, however, HLA expression on the cell‐surface is frequently reported as the total amount of HLA Class I or II antigens. This is despite evidence that indicates the differentia…
View article: Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study
Immune response after pig-to-human kidney xenotransplantation: a multimodal phenotyping study Open
View article: Integrative Multi-omic Profiling of Two Human Decedents Receiving Pig Heart Xenografts Reveals Strong Perturbations in Early Immune-Cell and Cellular Metabolism Responses
Integrative Multi-omic Profiling of Two Human Decedents Receiving Pig Heart Xenografts Reveals Strong Perturbations in Early Immune-Cell and Cellular Metabolism Responses Open
Background Recent advances in xenotransplantation in living and decedent humans using pig xenografts have laid promising groundwork towards future emergency use and first in human trials. Major obstacles remain though, including a lack of …
View article: Immunologic risk stratification of pediatric heart transplant patients by combining HLA-EMMA and PIRCHE-II
Immunologic risk stratification of pediatric heart transplant patients by combining HLA-EMMA and PIRCHE-II Open
Human leukocyte antigen (HLA) molecular mismatch is a powerful biomarker of rejection. Few studies have explored its use in assessing rejection risk in heart transplant recipients. We tested the hypothesis that a combination of HLA Epitope…
View article: Abstracts of the 23rd Annual State of the Art Winter Symposium
Abstracts of the 23rd Annual State of the Art Winter Symposium Open
peer reviewed
View article: The Banff 2022 Kidney Meeting Work Plan: Data-Driven Refinement of the Banff Classification for Renal Allografts
The Banff 2022 Kidney Meeting Work Plan: Data-Driven Refinement of the Banff Classification for Renal Allografts Open
View article: Results of Two Cases of Pig-to-Human Kidney Xenotransplantation
Results of Two Cases of Pig-to-Human Kidney Xenotransplantation Open
Genetically modified kidney xenografts from pigs remained viable and functioning in brain-dead human recipients for 54 hours, without signs of hyperacute rejection. (Funded by Lung Biotechnology.).
View article: Approaching the sensitized lung patient: risk assessment for donor acceptance
Approaching the sensitized lung patient: risk assessment for donor acceptance Open
The presence of HLA antibodies is widely recognized as a barrier to solid organ transplantation, and for lung transplant candidates, it has a significant negative impact on both waiting time and waiting list mortality. Although HLA antibod…
View article: HLA Eplet Mismatch Analysis of a Large Multi-Center Pediatric Heart Transplant Cohort: Not All Transplants are Immunologically Equal
HLA Eplet Mismatch Analysis of a Large Multi-Center Pediatric Heart Transplant Cohort: Not All Transplants are Immunologically Equal Open
View article: Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells
Immune Responses of HLA Highly Sensitized and Nonsensitized Patients to Genetically Engineered Pig Cells Open
(i) End-stage renal disease was associated with low antipig antibody levels. (ii) Xenoreactivity decreased with increased genetic engineering of pig cells. (iii) High cPRA status had no significant effect on antibody binding or T-cell and …
View article: Short-term adverse effects of early subclinical allograft inflammation in kidney transplant recipients with a rapid steroid withdrawal protocol
Short-term adverse effects of early subclinical allograft inflammation in kidney transplant recipients with a rapid steroid withdrawal protocol Open
View article: Proteasome Inhibitor Carfilzomib-Based Therapy for Antibody-Mediated Rejection of the Pulmonary Allograft: Use and Short-Term Findings
Proteasome Inhibitor Carfilzomib-Based Therapy for Antibody-Mediated Rejection of the Pulmonary Allograft: Use and Short-Term Findings Open
We present this observational study of lung transplant recipients (LTR) treated with carfilzomib (CFZ)-based therapy for antibody-mediated rejection (AMR) of the lung. Patients were considered responders to CFZ if complement-1q (C1q)-fixin…
View article: Significance of Anti-HLA Antibodies on Adult and Pediatric Heart Allograft Outcomes
Significance of Anti-HLA Antibodies on Adult and Pediatric Heart Allograft Outcomes Open
As methods for human leukocyte antigens (HLA) antibody detection have evolved and newer solid phase assays are much more sensitive, the last 15 years has seen a renewed focus on the importance of HLA antibodies in solid organ transplant re…
View article: From Humoral Theory to Performant Risk Stratification in Kidney Transplantation
From Humoral Theory to Performant Risk Stratification in Kidney Transplantation Open
The purpose of the present review is to describe how we improve the model for risk stratification of transplant outcomes in kidney transplantation by incorporating the novel insights of donor-specific anti-HLA antibody (DSA) characteristic…