Massimo S. Fiandaca
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View article: Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2<b>–</b>Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease
Intraputaminal Delivery of Adeno‐Associated Virus Serotype 2<b>–</b>Glial Cell Line–Derived Neurotrophic Factor in Mild or Moderate Parkinson's Disease Open
Background Glial cell line–derived neurotrophic factor (GDNF) is required for development and survival of dopaminergic neurons. A previous trial evaluating lower‐dose adeno‐associated virus serotype 2–GDNF (AAV2‐GDNF) bilateral intraputami…
View article: Neurotrophic factors for Parkinson's disease: Current status, progress, and remaining questions. Conclusions from a 2023 workshop
Neurotrophic factors for Parkinson's disease: Current status, progress, and remaining questions. Conclusions from a 2023 workshop Open
In 2023, a workshop was organized by the UK charity Cure Parkinson's with The Michael J Fox Foundation for Parkinson's Research and Parkinson's UK to review the field of growth factors (GFs) for Parkinson's disease (PD). This was a follow …
View article: Plasma metabolomics indexes time to clinical dementia in autosomal dominant Alzheimer’s disease mutation carriers
Plasma metabolomics indexes time to clinical dementia in autosomal dominant Alzheimer’s disease mutation carriers Open
Background Metabolic dysregulation has been implicated in the pathobiology of Alzheimer’s disease (AD), including familial autosomal dominant AD (ADAD). Recent metabolic neuroimaging of preclinical ADAD mutation carriers has suggested that…
View article: TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC
TGFβ Drives Metabolic Perturbations during Epithelial Mesenchymal Transition in Pancreatic Cancer: TGFβ Induced EMT in PDAC Open
Pancreatic ductal adenocarcinoma (PDAC) is a highly lethal malignancy wherein a majority of patients present metastatic disease at diagnosis. Although the role of epithelial to mesenchymal transition (EMT), mediated by transforming growth …
View article: Plasma Sphingomyelins in Late-Onset Alzheimer’s Disease
Plasma Sphingomyelins in Late-Onset Alzheimer’s Disease Open
Background: Altered plasma levels of sphingolipids, including sphingomyelins (SM), have been found in mouse models of Alzheimer’s disease (AD) and in AD patient plasma samples. Objective: This study assesses fourteen plasma SM species in a…
View article: Foetal bovine serum influence on in vitro extracellular vesicle analyses
Foetal bovine serum influence on in vitro extracellular vesicle analyses Open
Extracellular vesicles (EVs) are nanosized lipid bilayer vesicles most notably from either endosomal (i.e., exosomes) or plasma membrane origins (i.e., microvesicles/ectosomes) and released from nearly all mammalian cells (Colombo et al., …
View article: Advancing gene therapies, methods, and technologies for Parkinson’s Disease and other neurological disorders
Advancing gene therapies, methods, and technologies for Parkinson’s Disease and other neurological disorders Open
Expanded indications and demand for CNS gene therapies will require a worldwide educational effort to supplement the training of clinical neuroscience practitioners. Initially, a limited number of Centres of Excellence will need to establi…
View article: GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop
GDNF and Parkinson’s Disease: Where Next? A Summary from a Recent Workshop Open
The concept of repairing the brain with growth factors has been pursued for many years in a variety of neurodegenerative diseases including primarily Parkinson's disease (PD) using glial cell line-derived neurotrophic factor (GDNF). This n…
View article: Response to “Technical approaches to reduce interference of Fetal calf serum derived RNA in the analysis of extracellular vesicle RNA from cultured cells”
Response to “Technical approaches to reduce interference of Fetal calf serum derived RNA in the analysis of extracellular vesicle RNA from cultured cells” Open
We read with great interest the article by Driedonks and colleagues (2019) on “Technical approaches to reduce interference of fetal calf serum derived RNA in the analysis of extracellular vesicle R...
View article: Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study
Applicability of in vivo staging of regional amyloid burden in a cognitively normal cohort with subjective memory complaints: the INSIGHT-preAD study Open
Background Current methods of amyloid PET interpretation based on the binary classification of global amyloid signal fail to identify early phases of amyloid deposition. A recent analysis of 18F-florbetapir PET data from the Alzheimer’s di…
View article: <p>MOL2NET: FROM MOLECULES TO NETWORKS (PROC. BOOK), <span>ISBN</span><span>: </span><span>978-3-03842-820-6, </span>2019, Vol. 4, 2985 pp.</p>
MOL2NET: FROM MOLECULES TO NETWORKS (PROC. BOOK), <span>ISBN</span><span>: </span><span>978-3-03842-820-6, </span>2019, Vol. 4, 2985 pp. Open
International audience
View article: Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media
Fetal Bovine Serum-Derived Extracellular Vesicles Persist within Vesicle-Depleted Culture Media Open
It is known that culture media (CM) promotes cellular growth, adhesion, and protects explanted primary brain cells from in vitro stresses. The fetal bovine serum (FBS) supplement used in most CM, however, contains significant quantities of…
View article: Potential Metabolomic Linkage in Blood between Parkinson’s Disease and Traumatic Brain Injury
Potential Metabolomic Linkage in Blood between Parkinson’s Disease and Traumatic Brain Injury Open
The etiologic basis for sporadic forms of neurodegenerative diseases has been elusive but likely represents the product of genetic predisposition and various environmental factors. Specific gene-environment interactions have become more sa…
View article: Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls
Plasma metabolomic biomarkers accurately classify acute mild traumatic brain injury from controls Open
Past and recent attempts at devising objective biomarkers for traumatic brain injury (TBI) in both blood and cerebrospinal fluid have focused on abundance measures of time-dependent proteins. Similar independent determinants would be most …
View article: Metabolomic biomarkers of pancreatic cancer: a meta-analysis study
Metabolomic biomarkers of pancreatic cancer: a meta-analysis study Open
Pancreatic cancer (PC) is an aggressive disease with high mortality rates, however, there is no blood test for early detection and diagnosis of this disease. Several research groups have reported on metabolomics based clinical investigatio…