Matam Vijay–Kumar
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View article: Pharmacologic Inhibition of Erythrocyte Ferroportin Expression Exacerbates Plasmodium Infection
Pharmacologic Inhibition of Erythrocyte Ferroportin Expression Exacerbates Plasmodium Infection Open
Plasmodium parasites rely on host iron for survival and replication, making host iron availability a critical determinant of malaria pathogenesis. Central to iron homeostasis is the hepcidin–ferroportin regulatory axis, where hepcidin supp…
View article: Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat
Epigenetic Histone β-Hydroxybutyrylation Contributes to Renoprotection by β-Hydroxybutyrate in the Dahl Rat Open
BACKGROUND: Previously, we demonstrated that the ketone body, β-hydroxybutyrate, is a potent antihypertensive and reno-protective metabolite in Dahl Salt-Sensitive rats. However, the mechanism by which β-hydroxybutyrate confers these benef…
View article: Deficiency of interleukin-1 receptor antagonist aggravates <i>Citrobacter rodentium</i> infection in mice
Deficiency of interleukin-1 receptor antagonist aggravates <i>Citrobacter rodentium</i> infection in mice Open
The interleukin-1 receptor (IL-1R) plays an important role in mediating the inflammatory responses against pathogens. However, it is not clear whether a sustained IL-1R signaling following the loss of its endogenous inhibitor, IL-1R antago…
View article: A comparative Study of chemical and Biocontrol Measures on Whitegrub, Holotrichia serrata (Fabricius, 1781) in Sugarcane with an Emphasis on Sustainable Biological Approach
A comparative Study of chemical and Biocontrol Measures on Whitegrub, Holotrichia serrata (Fabricius, 1781) in Sugarcane with an Emphasis on Sustainable Biological Approach Open
A field experiment was carried out in farmers’ fields in Mastipur, Amarachinta and Itikyala villages, Wanaparthy dt., Telangana state in the wet seasons of 2021-22 and 2022-23 to evaluate eco-friendly strategies for the management of Holot…
View article: Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease
Gut Feelings: How Microbes, Diet, and Host Immunity Shape Disease Open
The human gut microbiome is intricately linked to systemic and organ-specific immune responses and is highly responsive to dietary modulation. As metagenomic techniques enable in-depth study of an ever-growing number of gut microbial speci…
View article: Dynamics of antimicrobial proteins’ expression and their bactericidal activity in mouse milk
Dynamics of antimicrobial proteins’ expression and their bactericidal activity in mouse milk Open
Mother’s milk is considered as “complete edible immune system.” It contains macro- and micronutrients required to maintain infant growth and provides an excellent source for innate and adaptive immune proteins that not only protects infant…
View article: Leveraging circulating DNase I activity to detect silent coronary artery disease among hypertensive diabetes individuals
Leveraging circulating DNase I activity to detect silent coronary artery disease among hypertensive diabetes individuals Open
Our observation suggests that the progression of cardiac disease among hypertensive patients with diabetes is associated with elevated DNase I activity that maintains optimal cfDNA levels, thereby reducing its inflammatory potential and wo…
View article: Ketone body mediated histone β-hydroxybutyrylation is reno-protective
Ketone body mediated histone β-hydroxybutyrylation is reno-protective Open
Starvation, intermittent fasting and exercise, all of which are recommended lifestyle modifiers share a common metabolic signature, ketogenesis to generate the ketone bodies, predominantly β-hydroxybutyrate. β-hydroxybutyrate exerts benefi…
View article: Digestive dynamics: Unveiling interplay between the gut microbiota and the liver in macronutrient metabolism and hepatic metabolic health
Digestive dynamics: Unveiling interplay between the gut microbiota and the liver in macronutrient metabolism and hepatic metabolic health Open
Although the liver is the largest metabolic organ in the body, it is not alone in functionality and is assisted by “an organ inside an organ,” the gut microbiota. This review attempts to shed light on the partnership between the liver and …
View article: Hypertensive mice are more susceptible to experimental malaria
Hypertensive mice are more susceptible to experimental malaria Open
Translation: The University of Toledo Journal of Medical Sciences is the online journal launched by the University of Toledo. Manuscripts will be considered on the understanding that they report original work and are not under consideratio…
View article: STERILE NEUTROPHILIA INDUCED VIA CXCR4 ANTAGONISM MITIGATES COLONIC INFLAMMATION BY ENHANCING IMMUNOSUPPRESSIVE REGULATORY T CELLS IN MICE
STERILE NEUTROPHILIA INDUCED VIA CXCR4 ANTAGONISM MITIGATES COLONIC INFLAMMATION BY ENHANCING IMMUNOSUPPRESSIVE REGULATORY T CELLS IN MICE Open
Sterile neutrophilia (SN) is commonly associated with chronic diseases including inflammatory bowel diseases (IBD), but its defined role is largely unknown. Plerixafor (AMD3100) is a CXCR4 antagonist that promotes neutrophil egress from bo…
View article: Hypertension Increases Susceptibility to Experimental Malaria in Mice
Hypertension Increases Susceptibility to Experimental Malaria in Mice Open
Global prevalence of hypertension is on the rise, burdening healthcare, especially in developing countries where infectious diseases, such as malaria, are also rampant. Whether hypertension could predispose or increase susceptibility to ma…
View article: Effect of copper and cobalt nanoparticles supplementation on methane emission and milk production in Gir cows fed with rice gruel diet
Effect of copper and cobalt nanoparticles supplementation on methane emission and milk production in Gir cows fed with rice gruel diet Open
The feeding of rice gruel is common practice in India. The feeding of rice gruel causes metabolic diseases. The study was carried out to evaluate the effect of nanomineralson methane emission and milk production in Gir cows fed on rice gru…
View article: Psyllium fiber protects mice against western diet-induced metabolic syndrome via the gut microbiota-dependent mechanism
Psyllium fiber protects mice against western diet-induced metabolic syndrome via the gut microbiota-dependent mechanism Open
Impacts of dietary fiber on intestinal inflammation are complex, but some specific semi-purified fibers, particularly psyllium, can protect humans and rodents against colitis. Mechanisms underlying such protection are not fully understood …
View article: Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor–deficient mice
Loss of toll-like receptor 5 potentiates spontaneous hepatocarcinogenesis in farnesoid X receptor–deficient mice Open
Background: HCC is the most common primary liver cancer and a leading cause of cancer-related mortality. Gut microbiota is a large collection of microbes, predominately bacteria, that harbor the gastrointestinal tract. Changes in gut micro…
View article: Combating Hypertension Beyond GWAS: Microbiome and Artificial Intelligence as Opportunities for Precision Medicine
Combating Hypertension Beyond GWAS: Microbiome and Artificial Intelligence as Opportunities for Precision Medicine Open
The single largest contributor to human mortality is cardiovascular disease, the top risk factor for which is hypertension (HTN). The last two decades have placed much emphasis on the identification of genetic factors contributing to HTN. …
View article: Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites
Conjugated bile acids are nutritionally re-programmable antihypertensive metabolites Open
Background: Hypertension is the largest risk factor affecting global mortality. Despite available medications, uncontrolled hypertension is on the rise, whereby there is an urgent need to develop novel and sustainable therapeutics. Because…
View article: Supplementary data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance
Supplementary data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance Open
Supplementary figure 1 shows visualization of colonic stem cells using stem cell markers ASCL-2 and BMI-1 with negative controls in pigs. Supplementary figure 2 shows colonic stem cells using stem cell markers ASCL-2 and BMI-1 with negativ…
View article: Data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance
Data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance Open
Basal colonic crypt stem cells are long lived and play a role in colon homeostasis. Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker…
View article: Supplementary data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance
Supplementary data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance Open
Supplementary figure 1 shows visualization of colonic stem cells using stem cell markers ASCL-2 and BMI-1 with negative controls in pigs. Supplementary figure 2 shows colonic stem cells using stem cell markers ASCL-2 and BMI-1 with negativ…
View article: Data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance
Data from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance Open
Basal colonic crypt stem cells are long lived and play a role in colon homeostasis. Previous evidence has shown that high-calorie diet (HCD) enhances colonic stem cell numbers and expansion of the proliferative zone, an important biomarker…
View article: Supplementary table 1 from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance
Supplementary table 1 from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance Open
Supplementary table 1 shows body weight, daily weight gain and feed intake data.
View article: Supplementary table 1 from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance
Supplementary table 1 from Pigs, Unlike Mice, Have Two Distinct Colonic Stem Cell Populations Similar to Humans That Respond to High-Calorie Diet prior to Insulin Resistance Open
Supplementary table 1 shows body weight, daily weight gain and feed intake data.
View article: Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats
Bacterial flagellin is a dominant, stable innate immune activator in the gastrointestinal contents of mice and rats Open
Intestinal contents comprise the largest repository of immunogenic ligands of microbial origin. We undertook this study to assess the predominant microbe-associated molecular patterns (MAMPs) present therein and the receptors) that mediate…
View article: Gut microbiota lends a helping hand to nurse liver regeneration
Gut microbiota lends a helping hand to nurse liver regeneration Open
Gut microbiota promote liver regeneration through hepatic membrane phospholipid biosynthesisJournal of HepatologyVol. 78Issue 4PreviewHepatocyte growth and proliferation depends on membrane phospholipid biosynthesis. Short-chain fatty acid…
View article: Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy
Crosstalk between Gut Microbiota and Host Immunity: Impact on Inflammation and Immunotherapy Open
Gut microbes and their metabolites are actively involved in the development and regulation of host immunity, which can influence disease susceptibility. Herein, we review the most recent research advancements in the gut microbiota–immune a…
View article: Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice
Urine-based Detection of Congenital Portosystemic Shunt in C57BL/6 Mice Open
Sporadic occurrence of congenital portosystemic shunt (PSS) at a rate of ∼1 out of 10 among C57BL/6 J mice, which are widely used in biomedical research, results in aberrancies in serologic, metabolic, and physiologic parameters. Therefore…