Matcheri S. Keshavan
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View article: Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics
Shift in sex and age of individuals at a clinical high risk (CHR) for psychosis: relation to differences in recruitment methods and effect on sample characteristics Open
View article: Defining and Engaging a Novel rTMS Target for Nicotine Craving in Psychotic Disorders
Defining and Engaging a Novel rTMS Target for Nicotine Craving in Psychotic Disorders Open
Tobacco use is the top preventable cause of early mortality in schizophrenia, but the underlying pathophysiology remains unknown. In schizophrenia, small studies have linked default mode network (DMN) organization to tobacco use and showed…
View article: Development and administration of the flexible adapted cognitive test battery for schizophrenia (FACTS)
Development and administration of the flexible adapted cognitive test battery for schizophrenia (FACTS) Open
View article: Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study
Neural fingerprints of data driven cognitive subtypes across the psychosis spectrum: a B-SNIP study Open
View article: Independence-based causal discovery analysis reveals statistically non-significant regions to be functionally significant
Independence-based causal discovery analysis reveals statistically non-significant regions to be functionally significant Open
Background and Hypothesis Traditional fMRI analyses often ignore regions that fail to reach statistical significance, assuming they are biologically unimportant. We tested the accuracy of this assumption using causal discovery based-analys…
View article: Social cognition as a mediator between neurocognition and functional outcome in early course schizophrenia
Social cognition as a mediator between neurocognition and functional outcome in early course schizophrenia Open
Social cognition is an established mediator between neurocognition and functional outcome in schizophrenia, but there is limited evidence for this model specifically in the early course, which is a critical window for intervention to reduc…
View article: The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures
The electroencephalography protocol for the Accelerating Medicines Partnership® Schizophrenia Program: Reliability and stability of measures Open
Individuals at clinical high risk for psychosis (CHR) have variable clinical outcomes and low conversion rates, limiting development of novel and personalized treatments. Moreover, given risks of antipsychotic drugs, safer effective medica…
View article: Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program
Digital health technologies in the accelerating medicines Partnership® Schizophrenia Program Open
View article: Development, validation and feasibility testing of a 12-minute Yoga-Breath Linked Intervention to Stop Smoking (Y-BLISS) module
Development, validation and feasibility testing of a 12-minute Yoga-Breath Linked Intervention to Stop Smoking (Y-BLISS) module Open
A BSTRACT Objectives: This study aimed to develop and validate the yoga-breath-linked intervention to stop smoking (Y-BLISS), a novel, scalable, and cost-effective yoga-based module for smoking cessation as an add-on to standard care. Meth…
View article: Cholinergic system in schizophrenia: A systematic review and meta-analysis
Cholinergic system in schizophrenia: A systematic review and meta-analysis Open
Our review demonstrates a widespread decrease in muscarinic and nicotinic receptor levels in schizophrenia, evident in both neuroimaging and post-mortem studies. Our meta-analyses show large to moderate effects for the reductions in M1/M4 …
View article: Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum
Cerebral perfusion differences in the visual cortex and fusiform subregions across the psychosis spectrum Open
Background Approximately 50% of individuals with psychosis spectrum disorders (PSD) experience visual hallucinations and deficits in visual processing. Cerebral blood flow (CBF) alterations have been identified in the occipital lobe (OL) a…
View article: Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part I Open
Purpose/Background Clozapine was approved in the United States (US) using 1989 regulations and knowledge. After 30 years, many sections of the US package insert (PI) are outdated. Methods We comprehensively reviewed the literature to propo…
View article: Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II
Letter to the FDA Proposing Major Changes in the US Clozapine Package Insert Supported by Clozapine Experts Worldwide. Part II Open
Purpose/Background This is the second part of a 2-part article that proposes improving the United States (US) clozapine package insert. Part II focuses on fatal outcomes and the 5 boxed warnings, 4 specifically for clozapine: severe neutro…
View article: Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample
Cognitive assessment in the Accelerating Medicines Partnership® Schizophrenia Program: harmonization priorities and strategies in a diverse international sample Open
Cognitive impairment occurs at higher rates in individuals at clinical high risk (CHR) for psychosis relative to healthy peers, and it contributes unique variance to multivariate prediction models of transition to psychosis. Such impairmen…
View article: Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies
Brain Markers of Resilience to Psychosis in High-Risk Individuals: A Systematic Review and Label-Based Meta-Analysis of Multimodal MRI Studies Open
Background/objectives: Most individuals who have a familial or clinical risk to develop psychosis remain free from psychopathology. Identifying neural markers of resilience in these at-risk individuals may help clarify underlying mechanism…
View article: Exposotypes in Psychotic Disorders
Exposotypes in Psychotic Disorders Open
Psychiatry lags in adopting etiological approaches to diagnosis, prognosis, and outcome prediction compared to the rest of medicine. Etiological factors such as childhood trauma (CHT), substance use (SU), and socioeconomic status (SES) sig…
View article: Neuroanatomical Deficits in Visual Cortex Subregions of Individuals with Psychosis Spectrum Disorders linked to Symptoms, Cognition, and Childhood Trauma
Neuroanatomical Deficits in Visual Cortex Subregions of Individuals with Psychosis Spectrum Disorders linked to Symptoms, Cognition, and Childhood Trauma Open
Objective The visual system is a significant site of pathology in psychosis spectrum disorders. However, there is limited research investigating human visual cortex (VC) subregions in this population. Using data from the Bipolar-Schizophre…
View article: Predicting conversion to psychosis using machine learning: response to Cannon
Predicting conversion to psychosis using machine learning: response to Cannon Open
Background We previously reported that machine learning could be used to predict conversion to psychosis in individuals at clinical high risk (CHR) for psychosis with up to 90% accuracy using the North American Prodrome Longitudinal Study-…
View article: Improving knowledge, attitude, and practice of nurses on childhood cancer care through a structured teaching program
Improving knowledge, attitude, and practice of nurses on childhood cancer care through a structured teaching program Open
View article: Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2
Cognitive performance and differentiation of B-SNIP psychosis Biotypes: Algorithmic Diagnostics for Efficient Prescription of Treatments (ADEPT) - 2 Open
View article: Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations
Genetic Analysis of Psychosis Biotypes: Shared Ancestry-Adjusted Polygenic Risk and Unique Genomic Associations Open
The Bipolar-Schizophrenia Network for Intermediate Phenotypes (B-SNIP) created psychosis Biotypes based on neurobiological measurements in a multi-ancestry sample. These Biotypes cut across DSM diagnoses of schizophrenia, schizoaffective d…
View article: Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis
Attention Deficit Hyperactivity Disorder among Youth at Clinical High Risk of Psychosis Open
Attention Deficit Hyperactivity Disorder (ADHD) affects a significant proportion of the population and is associated with numerous adverse outcomes including lower educational attainment, occupational challenges, increased substance use, a…
View article: Sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives
Sleep oscillations and their relations with sleep-dependent memory consolidation in early course psychosis and first-degree relatives Open
Sleep spindles mediate sleep-dependent memory consolidation, particularly when coupled to neocortical slow oscillations (SOs). Schizophrenia is characterized by a deficit in sleep spindles that correlates with reduced overnight memory cons…
View article: Dissociable Default Mode Network Connectivity Patterns Underlie Distinct Symptoms in Psychosis Risk
Dissociable Default Mode Network Connectivity Patterns Underlie Distinct Symptoms in Psychosis Risk Open
The Clinical High Risk (CHR) stage of psychosis is characterized by subthreshold symptoms of schizophrenia including negative symptoms, dysphoric mood, and functional deterioration. Hyperconnectivity of the default-mode network (DMN) has b…
View article: Cognitive subtypes in youth at clinical high risk for psychosis
Cognitive subtypes in youth at clinical high risk for psychosis Open
Introduction Schizophrenia is a mental health condition that severely impacts well-being. Cognitive impairment is among its core features, often presenting well before the onset of overt psychosis, underscoring a critical need to study it …
View article: Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples
Fetal Gene Regulatory Gene Deletions are Associated with Poor Cognition in Schizophrenia and Community-Based Samples Open
Objective Schizophrenia is a neurodevelopmental disorder involving clinical and genetic heterogeneity. Multiple recurrent copy number variants (CNVs) increase risk for schizophrenia spectrum disorders (SSD). However, how known risk CNVs an…
View article: Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome
Robust Brain Correlates of Cognitive Performance in Psychosis and Its Prodrome Open
View article: Digital phenotyping correlates of mobile cognitive measures in schizophrenia: A multisite global mental health feasibility trial
Digital phenotyping correlates of mobile cognitive measures in schizophrenia: A multisite global mental health feasibility trial Open
Traditional cognitive assessments in schizophrenia are time-consuming and necessitate specialized training, making routine evaluation challenging. To overcome these limitations, this study investigates the feasibility and advantages of uti…
View article: Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis
Evidence from comprehensive independent validation studies for smooth pursuit dysfunction as a sensorimotor biomarker for psychosis Open
Smooth pursuit eye movements are considered a well-established and quantifiable biomarker of sensorimotor function in psychosis research. Identifying psychotic syndromes on an individual level based on neurobiological markers is limited by…
View article: Characterizing the Relationship between Personality Dimensions and Psychosis-Specific Clinical Characteristics
Characterizing the Relationship between Personality Dimensions and Psychosis-Specific Clinical Characteristics Open
Background Past studies associating personality with psychosis have been limited by small nonclinical samples and a focus on general symptom burden. This study uses a large clinical sample to examine personality’s relationship with psychos…