Máté Maus
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View article: Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells
Release of mitochondrial dsRNA into the cytosol is a key driver of the inflammatory phenotype of senescent cells Open
The escape of mitochondrial double-stranded dsRNA (mt-dsRNA) into the cytosol has been recently linked to a number of inflammatory diseases. Here, we report that the release of mt-dsRNA into the cytosol is a general feature of senescent ce…
View article: Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression
Iron chelation as a new therapeutic approach to prevent senescence and liver fibrosis progression Open
Iron overload and cellular senescence have been implicated in liver fibrosis, but their possible mechanistic connection has not been explored. To address this, we have deepened into the role of iron and senescence in an experimental model …
View article: #5672 CORTICAL IRON DEPOSITION ASSESSED BY MAGNETIC RESONANCE IMAGE IS ASSOCIATED WITH KIDNEY FIBROSIS
#5672 CORTICAL IRON DEPOSITION ASSESSED BY MAGNETIC RESONANCE IMAGE IS ASSOCIATED WITH KIDNEY FIBROSIS Open
Background and Aims Fibrosis is responsible for the loss of kidney function as a result of several insults, such as ischemia-reperfusion injury or hyperfiltration. This process can continue even after cessation of the primary insult, as do…
View article: The lysosomal proteome of senescent cells contributes to the senescence secretome
The lysosomal proteome of senescent cells contributes to the senescence secretome Open
Senescent cells accumulate in tissues over time, favoring the onset and progression of multiple age‐related diseases. Senescent cells present a remarkable increase in lysosomal mass and elevated autophagic activity. Here, we report that tw…
View article: Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype
Iron accumulation drives fibrosis, senescence, and the senescence-associated secretory phenotype Open
Fibrogenesis is part of a normal protective response to tissue injury that can become irreversible and progressive, leading to fatal diseases. Senescent cells are a main driver of fibrotic diseases through their secretome, known as senesce…
View article: STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells
STIM1‐mediated calcium influx controls antifungal immunity and the metabolic function of non‐pathogenic Th17 cells Open
Immunity to fungal infections is mediated by cells of the innate and adaptive immune system including Th17 cells. Ca2+ influx in immune cells is regulated by stromal interaction molecule 1 (STIM1) and its activation of the Ca2+ channel ORA…
View article: Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells
Ca2+ Signaling but Not Store-Operated Ca2+ Entry Is Required for the Function of Macrophages and Dendritic Cells Open
Store-operated Ca2+ entry (SOCE) through Ca2+ release–activated Ca2+ (CRAC) channels is essential for immunity to infection. CRAC channels are formed by ORAI1 proteins in the plasma membrane and activated by stromal interaction molecule (S…
View article: Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation
Missense mutation in immunodeficient patients shows the multifunctional roles of coiled-coil domain 3 (CC3) in STIM1 activation Open
Significance Stromal interaction molecule (STIM) 1 is an essential activator of the ORAI1 calcium (Ca 2+ ) channel that mediates Ca 2+ entry into many cell types. Patients with mutations in STIM1 or ORAI1 genes suffer from a severe immunod…