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View article: Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model
Pre-trauma cognitive traits predict fear generalization and associated prefrontal functioning in a longitudinal rodent model Open
Posttraumatic stress disorder (PTSD) is a chronic psychiatric condition that develops in susceptible individuals exposed to traumatic stress. Identifying predisposing risk factors and mechanisms presents a significant challenge for prevent…
View article: Repeated behavioral testing and the use of summary measures reveal trait anxiety in preclinical rodent models
Repeated behavioral testing and the use of summary measures reveal trait anxiety in preclinical rodent models Open
The reliability and validity of preclinical anxiety testing is essential for translating animal research into clinical use. However, the commonly used anxiety tests lack inter-test correlations and face challenges with repeatability. While…
View article: ChatGPT M.D.: Is there any room for generative AI in neurology?
ChatGPT M.D.: Is there any room for generative AI in neurology? Open
ChatGPT, a general artificial intelligence, has been recognized as a powerful tool in scientific writing and programming but its use as a medical tool is largely overlooked. The general accessibility, rapid response time and comprehensive …
View article: Alterations in resting-state gamma-activity is adults with autism spectrum disorder: A High-Density EEG study
Alterations in resting-state gamma-activity is adults with autism spectrum disorder: A High-Density EEG study Open
Autism spectrum disorder (ASD) is a neurodevelopmental disorder with a wide range of symptoms that include deficits in social cognition and difficulties with social interactions. Neural oscillations in the EEG gamma band have been proposed…
View article: Gamma activity in Autism Spectrum Disorder: Enhanced response to visual input
Gamma activity in Autism Spectrum Disorder: Enhanced response to visual input Open
Introduction Autism spectrum disorder (ASD) is a childhood onset neurodevelopmental condition, that leads to permanent disability in a high proportion of cases. ASD is associated with a heterogeneous symptom presentation, which - besides s…
View article: Pretrauma cognitive traits predict trauma-induced fear generalization and associated prefrontal functioning in a longitudinal model of posttraumatic stress disorder
Pretrauma cognitive traits predict trauma-induced fear generalization and associated prefrontal functioning in a longitudinal model of posttraumatic stress disorder Open
Posttraumatic stress disorder (PTSD) is a chronic psychiatric condition that develops in susceptible individuals exposed to traumatic stress, challenging clinicians to identify risk factors and mechanisms for mitigating vulnerability. Here…
View article: Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder
Endocannabinoid and neuroplasticity-related changes as susceptibility factors in a rat model of posttraumatic stress disorder Open
Traumatic experiences result in the development of posttraumatic stress disorder (PTSD) in 10-25% of exposed individuals. While human clinical studies suggest that susceptibility is potentially linked to endocannabinoid (eCB) signaling, ne…
View article: Findings from a Pilot of a Near Real Time Disease Surveillance Tool on the NATO Mission in Kosovo
Findings from a Pilot of a Near Real Time Disease Surveillance Tool on the NATO Mission in Kosovo Open
NATO has a requirement for a near real time surveillance (NRTS) tool to rapidly identify disease outbreaks but no deployable tool is available. The NATO Centre of Excellence for Military Medicine (MILMED COE) developed a NRTS tool and pilo…
View article: Improving anxiety research: novel approach to reveal trait anxiety through summary measures of multiple states
Improving anxiety research: novel approach to reveal trait anxiety through summary measures of multiple states Open
The reliability and validity of preclinical anxiety testing is essential for translating animal research into clinical use. However, the commonly used anxiety tests lack inter-test correlations and face challenges with repeatability. While…
View article: Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets
Post-weaning social isolation in male mice leads to abnormal aggression and disrupted network organization in the prefrontal cortex: Contribution of parvalbumin interneurons with or without perineuronal nets Open
Adverse social experiences during childhood increase the risk of developing aggression-related psychopathologies. The prefrontal cortex (PFC) is a key regulator of social behavior, where experience-dependent network development is tied to …
View article: Resource-efficient machining through physics-informed machine learning
Resource-efficient machining through physics-informed machine learning Open
Resource-efficient machining has been at the forefront of sustainable manufacturing for many years. However, the total life of the cutting tool is often not fully exploited to avoid the severe consequences of excessive wear. This conservat…
View article: Low Dark Current Organic Photodetectors Utilizing Highly Cyanated Non-fullerene Acceptors
Low Dark Current Organic Photodetectors Utilizing Highly Cyanated Non-fullerene Acceptors Open
Organic materials combining high electron affinity with strong absorption in the visible spectrum are of interest for photodetector applications. In this study, we report two such molecular semiconductors, based upon an acceptor-donor-acce…
View article: Bioresorbable implants vs. Kirschner-wires in the treatment of severely displaced distal paediatric radius and forearm fractures – a retrospective multicentre study
Bioresorbable implants vs. Kirschner-wires in the treatment of severely displaced distal paediatric radius and forearm fractures – a retrospective multicentre study Open
Background Distal radius fractures are very common in paediatric patients. Severely displaced fractures may require surgical intervention. The gold standard surgical method is percutaneous K-wire osteosynthesis followed by immobilisation. …
View article: Exploring Public Opinions on Renewable Energy by Using Conventional Methods and Social Media Analysis
Exploring Public Opinions on Renewable Energy by Using Conventional Methods and Social Media Analysis Open
Renewable energy is one of the most discussed topics nowadays, more so than traditional combustible energy sources and nuclear energy. There is an apparent need to study its public acceptance and the general public’s knowledge about it, es…
View article: Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice
Somatostatin Neurons of the Bed Nucleus of Stria Terminalis Enhance Associative Fear Memory Consolidation in Mice Open
Excessive fear learning and generalized, extinction-resistant fear memories are core symptoms of anxiety and trauma-related disorders. Despite significant evidence from clinical studies reporting hyperactivity of the bed nucleus of stria t…
View article: Somatostatin neurons of the bed nucleus of stria terminalis enhance associative fear memory consolidation in mice
Somatostatin neurons of the bed nucleus of stria terminalis enhance associative fear memory consolidation in mice Open
Excessive fear learning and extinction-resistant fear memories are core symptoms of anxiety and trauma-related disorders. Despite significant evidence from clinical studies reporting hyperactivity of the bed nucleus of stria terminalis (BN…
View article: Hungarian Energy Law as an Example of Using Complex System Viewpoints to Understand Risks in Public Administration Normativity
Hungarian Energy Law as an Example of Using Complex System Viewpoints to Understand Risks in Public Administration Normativity Open
Complex networks and complex adaptive systems theories come from hard sciences. The question arises whether these viewpoints can add anything to the understanding of the operation and failures of continental normativity governing the publi…
View article: Heritable Differences in Catecholamine Signaling Modulate Susceptibility to Trauma and Response to Methylphenidate Treatment: Relevance for PTSD
Heritable Differences in Catecholamine Signaling Modulate Susceptibility to Trauma and Response to Methylphenidate Treatment: Relevance for PTSD Open
Alterations in cortical catecholamine signaling pathways can modulate acute and enduring responses to trauma. Heritable variation in catecholamine signaling is produced by a common functional polymorphism in the catechol-O-methyltransferas…
View article: In Vitro Fracture Resistance of Adhesively Restored Molar Teeth with Different MOD Cavity Dimensions
In Vitro Fracture Resistance of Adhesively Restored Molar Teeth with Different MOD Cavity Dimensions Open
Purpose Molar MOD (mesial‐occlusal‐distal) cavity preparation weakens relative cuspal stiffness by up to 63%, often resulting in cuspal fracture. This investigation inspects fracture resistance of MOD cavities restored using direct composi…
View article: Task Division within the Prefrontal Cortex: Distinct Neuron Populations Selectively Control Different Aspects of Aggressive Behavior via the Hypothalamus
Task Division within the Prefrontal Cortex: Distinct Neuron Populations Selectively Control Different Aspects of Aggressive Behavior via the Hypothalamus Open
An important question in behavioral neurobiology is how particular neuron populations and pathways mediate the overall roles of brain structures. Here we investigated this issue by studying the medial prefrontal cortex (mPFC), an establish…