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View article: How does autophagy impact neurological function?
How does autophagy impact neurological function? Open
Autophagies describe a set of processes in which cells degrade their cytoplasmic contents via various routes that terminate with the lysosome. In macroautophagy (the focus of this review, henceforth autophagy), cytoplasmic contents, includ…
View article: Autophagy, aging, and age-related neurodegeneration
Autophagy, aging, and age-related neurodegeneration Open
Autophagy is a conserved mechanism that degrades damaged or superfluous cellular contents and enables nutrient recycling under starvation conditions. Many neurodegeneration-associated proteins are autophagy substrates, and autophagy upregu…
View article: Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration
Microglial-to-neuronal CCR5 signaling regulates autophagy in neurodegeneration Open
In neurodegenerative diseases, microglia switch to an activated state, which results in excessive secretion of pro-inflammatory factors. Our work aims to investigate how this paracrine signaling affects neuronal function. Here, we show tha…
View article: Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels
Optineurin Deficiency and Insufficiency Lead to Higher Microglial TDP-43 Protein Levels Open
Mutations in optineurin, a ubiquitin-binding adaptor protein, cause amyotrophic lateral sclerosis (ALS), a fatal neurodegenerative disease of motor neurons linked to chronic inflammation and protein aggregation. The majority of ALS patient…