Márcia Machado Marinho
YOU?
Author Swipe
View article: Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps
Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps Open
Background/Objectives: The increasing prevalence of multidrug-resistant Staphylococcus aureus represents a major clinical challenge, primarily driven by the acquisition of multiple resistance mechanisms. Among these, efflux pumps such as N…
View article: Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling
Unraveling the Antihyperglycemic Effects of Dipeptyl Peptidase-4 Inhibitors in Rodents: A Multi-Faceted Approach Combining Effects on Glucose Homeostasis, Molecular Docking, and ADMET Profiling Open
Background/Objectives: Dipeptidyl peptidase-4 (DPP-4) inhibitors are antidiabetic agents that regulate blood glucose by preventing the degradation of active incretin hormones. Although clinically effective, this drug class is associated wi…
View article: Synthesis, Characterization, and Evaluation of the Anxiolytic Activity of Hydrazones Derived from the Drug Isoniazid, Using the Adult Zebrafish (<i>Danio rerio</i>) Model
Synthesis, Characterization, and Evaluation of the Anxiolytic Activity of Hydrazones Derived from the Drug Isoniazid, Using the Adult Zebrafish (<i>Danio rerio</i>) Model Open
Anxiety, a multidimensional behavioral disorder, has been widely studied in neuroscience to understand its causes. The medications available for treatment show variable efficacy and side effects. To discover new drugs, animal models such a…
View article: Evaluation of the Activity of Amino Chalcone Against <em>Staphylococcus</em> Strains Harboring Efflux Pumps
Evaluation of the Activity of Amino Chalcone Against <em>Staphylococcus</em> Strains Harboring Efflux Pumps Open
The emergence of efflux-mediated resistance in Staphylococcus aureus has limited the effectiveness of conventional antibiotics, highlighting the need for novel adjuvant compounds. This study investigated the synthetic chalcone CMA4DMA as a…
View article: Insights of ligand-based virtual screening in molecular docking and dynamics analysis of coumarin benzamides derivatives against Leishmaniasis
Insights of ligand-based virtual screening in molecular docking and dynamics analysis of coumarin benzamides derivatives against Leishmaniasis Open
Leishmaniasis is a neglected tropical disease that affects approximately 18 countries, resulting in around 54,000 cases annually. Brazil is responsible for approximately 76% of cases associated with cutaneous leishmaniasis, with Leishmania…
View article: Heterocyclic Hydroxychalcone Promotes Anxiolytic and Anticonvulsant Effects through Gabaergic Neuromodulation in Wild Adult Zebrafish
Heterocyclic Hydroxychalcone Promotes Anxiolytic and Anticonvulsant Effects through Gabaergic Neuromodulation in Wild Adult Zebrafish Open
Benzodiazepines are drugs used to treat anxiety disorders and epilepsy due to their hypnotic, anxiolytic and anticonvulsant functions. But due to existing adverse effects such as decreased psychomotor activity and impaired memory, new and …
View article: Synthetic Aminochalcone Prevents Hyperglycemia-Induced Anxiety and Delays Pentylenetetrazole-Induced Epileptic Crisis in Adult Zebrafish
Synthetic Aminochalcone Prevents Hyperglycemia-Induced Anxiety and Delays Pentylenetetrazole-Induced Epileptic Crisis in Adult Zebrafish Open
Neurological disorders are a major contributor to disability-adjusted life years (DALYs) worldwide, with anxiety and epilepsy being particularly prevalent. Among them, anxiety is among the top ten diseases and causes an annual cost of 42.3…
View article: Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From <i>Datura ferox</i> in Zebrafish
Antinociceptive and Anti‐inflammatory Effect of Nicandrin B Isolated From <i>Datura ferox</i> in Zebrafish Open
Nicandrin B (Nic B), a withanolide isolated from Datura ferox leaves, was investigated for its antinociceptive and anti‐inflammatory effects in adult zebrafish (Danio rerio). Animals treated with Nic B (4, 20, and 40 mg/kg) showed no toxic…
View article: Chalcone Derived from a Natural Product: An Integrated Approach of Quantum Chemical Calculations, Molecular Docking, ADME and Neuromodulation on Serotonergic Receptors in Adult Zebrafish
Chalcone Derived from a Natural Product: An Integrated Approach of Quantum Chemical Calculations, Molecular Docking, ADME and Neuromodulation on Serotonergic Receptors in Adult Zebrafish Open
Anxiety disorders are conditions characterized by heightened responses to perceived threats, resulting in symptoms that negatively affect everyday life. This study investigates the anxiolytic effect of a natural chalcone isolated from Crot…
View article: Participation of the TRPA1 Receptor in the Antinociceptive and Anti-Inflammatory Effect of the α, β-Amyrin Mixture in Adult Zebrafish (Danio rerio)
Participation of the TRPA1 Receptor in the Antinociceptive and Anti-Inflammatory Effect of the α, β-Amyrin Mixture in Adult Zebrafish (Danio rerio) Open
Inflammatory pain is a symptom associated with different human diseases, and they are treated with drugs that have several serious side effects. The triterpene mixture of α, β-amyrin (ABAM) has already been reported with antinociceptive an…
View article: Anxiolytic Effects of Indole Alkaloids From <i>Rauvolfia ligustrina</i> in Adult Zebrafish: Involvement of the GABAergic and 5‐HT Systems
Anxiolytic Effects of Indole Alkaloids From <i>Rauvolfia ligustrina</i> in Adult Zebrafish: Involvement of the GABAergic and 5‐HT Systems Open
Benzodiazepines are widely used in the treatment of anxiety, but their use may be interrupted due to side effects. This study evaluated the indole alkaloids isocarapanaubine (indole alkaloid 1 [AIN1]) and 18‐β‐hydroxy‐3‐epi‐α‐yohimbine (in…
View article: Anxiety behavior in adult Zebrafish modulated by the alkaloid fraction of Cissampelos sympodialis Eichl. roots
Anxiety behavior in adult Zebrafish modulated by the alkaloid fraction of Cissampelos sympodialis Eichl. roots Open
Cissampelos sympodialis (Menispermaceae), a species endemic to Brazil, it is used in folk medicine to treat inflammation and respiratory disorders. These activities are probably associated with the presence of alkaloids in the plant. This …
View article: Allosteric modulation of laeviganoid-based clerodane diterpenes derivatives in muscarinic acetylcholine M1 receptor against tinnitus: a structure-based virtual screening approach
Allosteric modulation of laeviganoid-based clerodane diterpenes derivatives in muscarinic acetylcholine M1 receptor against tinnitus: a structure-based virtual screening approach Open
Background Chronic tinnitus is a complication that affects the central nervous system, specifically the auditory cortex, causing a phantom perception of sounds and noises without any external acoustic stimulus. It is more frequent in men t…
View article: Evaluation of the Anxiolytic and Anticonvulsant Effect of <i>Marlierea eugeniopsoides</i> Essential Oils and Its Majority Constituents in Adult Zebrafish
Evaluation of the Anxiolytic and Anticonvulsant Effect of <i>Marlierea eugeniopsoides</i> Essential Oils and Its Majority Constituents in Adult Zebrafish Open
Benzodiazepines are medications used to treat anxiety and epilepsy disorders. However, because of the existing adverse effects, new and safer medications are being sought. Therefore, this study aims to evaluate the chemical composition and…
View article: Antibacterial and Antibiofilm Activities of Hydralazine, an Antihypertensive Drug: In Vitro and In Silico Approaches
Antibacterial and Antibiofilm Activities of Hydralazine, an Antihypertensive Drug: In Vitro and In Silico Approaches Open
Background: The rise of multidrug-resistant (MDR) bacteria poses a significant challenge to global public health, contributing to increased morbidity and mortality rates. In this context, the repurposing of existing drugs has emerged as a …
View article: Chemical Composition and Larvicidal Activity Against Aedes aegypti of the Leaf Essential Oils from Croton blanchetianus
Chemical Composition and Larvicidal Activity Against Aedes aegypti of the Leaf Essential Oils from Croton blanchetianus Open
The Aedes aegypti mosquito is the primary vector of dengue, a neglected disease and a serious public health problem in tropical countries. The control of this vector has been carried out using chemical insecticides, which impact human heal…
View article: Cymbopogon citratus Essential Oil Protects Tubular Renal Cells against Ischemia/Reoxygenation Injury - Involvement Nrf2/Keap1 Pathway
Cymbopogon citratus Essential Oil Protects Tubular Renal Cells against Ischemia/Reoxygenation Injury - Involvement Nrf2/Keap1 Pathway Open
Ischemia and reoxygenation (I/R) cause acute kidney injury with progression related to oxidative damage, mitochondrial dysfunction and cell death. Nrf2-Keap1 pathway is involved in this process. Cymbopogon citratus, used in popular medicin…
View article: Anthelmintic activity on Haemonchus contortus and toxicity of benzoyl-carvacrol: a study in vitro, in silico and in vivo
Anthelmintic activity on Haemonchus contortus and toxicity of benzoyl-carvacrol: a study in vitro, in silico and in vivo Open
Carvacrol is isolated from essential oils and possesses activity against gastrointestinal nematodes of small ruminants. Benzoylation has been proposed to improve its pharmacological and pharmacokinetic properties. The objectives of this st…
View article: (Eco)toxicokinetic Evaluation of the Natural Larvicide Cardanol Diene Against Aedes aegypti
(Eco)toxicokinetic Evaluation of the Natural Larvicide Cardanol Diene Against Aedes aegypti Open
Dengue is an arbovirus that has become a public health problem in Brazil, and its control generally consists of the use of insecticides belonging to the organophosphate and pyrethroid groups, which can cause deleterious effects on human he…
View article: Evaluation of Emulsification Techniques to Optimize the Properties of Chalcone Nanoemulsions for Antifungal Applications
Evaluation of Emulsification Techniques to Optimize the Properties of Chalcone Nanoemulsions for Antifungal Applications Open
Background/Objectives: Nanoemulsions (NEs) possess properties that enhance the solubility, bioavailability and therapeutic efficacy of drugs. Chalcones are compounds known for their antifungal properties. In this study, we evaluated differ…
View article: In vitro and silico Analysis of Amentoflavone against Candida albicans with a Competitive Action about Amphotericin B
In vitro and silico Analysis of Amentoflavone against Candida albicans with a Competitive Action about Amphotericin B Open
Introduction: Antifungal resistance is a global health problem, and alternatives for control and treatment must be sought. Thus, substances isolated from plants with antifungal capacity have received considerable attention in the pharmaceu…
View article: Polyphenols of four medicinal plants extracts and relation with antifungal activities through in vitro and in silico studies
Polyphenols of four medicinal plants extracts and relation with antifungal activities through in vitro and in silico studies Open
Several medicinal plant´s extracts contain phenolic compounds with antifungal properties useful in pharmaceutical formulations. This study selected species from Cocó River State Park in Fortaleza, Ceará, Brazil, and compare their efficienc…
View article: Anxiolytic and Anticonvulsant Effects of Fisetin Isolated from <i>Bauhinia pentandra</i> on Adult Zebrafish (<i>Danio rerio</i>)
Anxiolytic and Anticonvulsant Effects of Fisetin Isolated from <i>Bauhinia pentandra</i> on Adult Zebrafish (<i>Danio rerio</i>) Open
Anxiety and epilepsy are common worldwide and represent a primary global health concern. Fisetin, a flavonoid isolated from Bauhinia pentandra , has a wide range of biological activities may be a promising alternative to combat diseases re…
View article: In silico evaluation of rotenoids extracted from Clitoria fairchildiana against the Aedes aegypti virus
In silico evaluation of rotenoids extracted from Clitoria fairchildiana against the Aedes aegypti virus Open
Dengue is an arbovirus that has become a serious public health problem in Brazil, as well as in other tropical regions of the world due to population, economic, political, and social factors that contribute to the proliferation, circulatio…
View article: Effect of Cinnamaldehyde Chalcone on Behavior in Adult <i>Zebrafish</i> (Danio rerio): <i>In Silico</i> Approach
Effect of Cinnamaldehyde Chalcone on Behavior in Adult <i>Zebrafish</i> (Danio rerio): <i>In Silico</i> Approach Open
The study focuses on the anxiolytic potential of chalcone (2 E ,4 E )‐1‐(2‐hydroxyphenyl)‐5‐phenylpenta‐2,4‐dien‐1‐one (CHALCNM) in adult zebrafish . Successfully synthesized in 58 % yield, CHALCNM demonstrated no toxicity after 96 h of ex…