Mateus Trinconi Cunha
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View article: Chemotherapy alone for stage II–IVa laryngeal squamous cell carcinoma: A 20‐year follow‐up
Chemotherapy alone for stage II–IVa laryngeal squamous cell carcinoma: A 20‐year follow‐up Open
Background Current treatment options for nonmetastatic laryngeal squamous cell carcinoma include radiotherapy, chemoradiotherapy, and surgery, which can result in significant morbidity. This study reports the 20‐year outcomes of a single‐m…
View article: CT-Based Radiomics for a priori Predicting Response to Chemoradiation in Locally Advanced Lung Adenocarcinoma
CT-Based Radiomics for a priori Predicting Response to Chemoradiation in Locally Advanced Lung Adenocarcinoma Open
The standard treatment for patients with locally advanced non-small cell lung cancer (NSCLC) is concurrent chemoradiation. However, clinical responses are heterogeneous and generally not known until after the completion of therapy. Multipl…
View article: Age- and sex-specific normative curves for intracranial and ventricular volumes from head CT scans
Age- and sex-specific normative curves for intracranial and ventricular volumes from head CT scans Open
This study aims to establish age- and sex-specific normative curves for intracranial (ICV) and lateral ventricular volumes (LVV) using computed tomography (CT), addressing a significant gap in the literature. A total of 2153 head CT scans …
View article: Non-small cell lung cancer in Brazilian non-smokers and light-smokers: epidemiological, genotypic and clinical characteristics
Non-small cell lung cancer in Brazilian non-smokers and light-smokers: epidemiological, genotypic and clinical characteristics Open
The incidence of lung cancer in non-smokers and light smokers has increased worldwide. In Brazil, data regarding the epidemiology, risk factors, and molecular assessment of this subpopulation are scarce. Here, we present the results of a s…
View article: Top advances of the year: Developments of immunotherapy in cutaneous squamous cell carcinoma, 2023–2024
Top advances of the year: Developments of immunotherapy in cutaneous squamous cell carcinoma, 2023–2024 Open
Antibodies against PD‐1 (PD1i), such as cemiplimab and pembrolizumab, have demonstrated significant efficacy in advanced, unresectable cutaneous squamous cell carcinoma (cSCC). These agents elicit durable responses in approximately 45% of …
View article: An extracted individual patient data meta-analysis of immunotherapy plus chemotherapy as first-line treatment for endometrial cancer with a PD-L1 and PD-1 inhibitors subanalysis
An extracted individual patient data meta-analysis of immunotherapy plus chemotherapy as first-line treatment for endometrial cancer with a PD-L1 and PD-1 inhibitors subanalysis Open
View article: PD-1 or PD-L1 inhibitors in addition to first-line chemotherapy for endometrial cancer: an extracted individual patient data meta-analysis
PD-1 or PD-L1 inhibitors in addition to first-line chemotherapy for endometrial cancer: an extracted individual patient data meta-analysis Open
This meta-analysis validated the benefit of adding immunotherapy to platinum-based chemotherapy with respect to PFS. dMMR patients gain advantages from the inclusion of either anti-PD-1 or anti-PD-L1 agents, whereas pMMR patients only expe…
View article: Clinical Validation of a Deep Learning Model forSegmenting and Quantifying Intracranial andVentricular Volumes on Computed Tomography
Clinical Validation of a Deep Learning Model forSegmenting and Quantifying Intracranial andVentricular Volumes on Computed Tomography Open
The field of radiology is experiencing a surge in demand due to advances in medical imaging, particularly in techniques suchas magnetic resonance imaging and computed tomography (CT). However, the interpretation of these scans relies heavi…
View article: Long-term outcomes of neoadjuvant immunotherapy plus chemotherapy in patients with early-stage triple-negative breast cancer: an extracted individual patient data and trial-level meta-analysis
Long-term outcomes of neoadjuvant immunotherapy plus chemotherapy in patients with early-stage triple-negative breast cancer: an extracted individual patient data and trial-level meta-analysis Open
View article: Treatment Outcomes in Patients with Advanced Fibrolamellar Hepatocellular Carcinoma Under Systemic Treatment: Analysis of Clinical Characteristics, Management, and Radiomics
Treatment Outcomes in Patients with Advanced Fibrolamellar Hepatocellular Carcinoma Under Systemic Treatment: Analysis of Clinical Characteristics, Management, and Radiomics Open
FLHCC has unique features compared to conventional HCC, including young onset, gender balance, and absence of hepatopathy. Systemic therapies can provide encouraging survival, but lack of uniformity precludes defining a preferable regimen.…
View article: Non–Germ Cell Intrascrotal Tumors in Adults: A Retrospective Cohort of Localized and Metastatic Disease From a Tertiary Cancer Center
Non–Germ Cell Intrascrotal Tumors in Adults: A Retrospective Cohort of Localized and Metastatic Disease From a Tertiary Cancer Center Open
Purpose: Given their rarity, little is known about outcomes and optimal treatment strategies for non–germ cell intrascrotal tumors (NGCITs). Here, we report a retrospective cohort of NGCITs and describe clinicopathological features and tre…
View article: Predicting survival in metastatic non‐small cell lung cancer patients with poor ECOG‐PS: A single‐arm prospective study
Predicting survival in metastatic non‐small cell lung cancer patients with poor ECOG‐PS: A single‐arm prospective study Open
Background Patients with advanced non‐small cell lung cancer (NSCLC) are a heterogeneous population with short lifespan. We aimed to develop methods to better differentiate patients whose survival was >90 days. Methods We evaluated 83 char…
View article: Uso da inteligência artificial em Oncologia: Doctor in silico?
Uso da inteligência artificial em Oncologia: Doctor in silico? Open
View article: Tumor glycolytic profiling through <sup>18</sup>F-FDG PET/CT predicts immune checkpoint inhibitor efficacy in advanced NSCLC
Tumor glycolytic profiling through <sup>18</sup>F-FDG PET/CT predicts immune checkpoint inhibitor efficacy in advanced NSCLC Open
Background: A significant proportion of patients with non-small-cell lung cancer (NSCLC) do not respond to immune checkpoint inhibitors (ICIs). Since metabolic reprogramming with increased glycolysis is a hallmark of cancer and is involved…
View article: Tumor Glycolytic Profiling Through 18F-FDG PET/CT Predicts Immune Checkpoint Inhibitor Efficacy in Advanced NSCLC
Tumor Glycolytic Profiling Through 18F-FDG PET/CT Predicts Immune Checkpoint Inhibitor Efficacy in Advanced NSCLC Open
View article: OA02.02 Development of Machine Learning Model to Estimate Overall Survival in Patients with Advanced NSCLC and ECOG-PS > 1
OA02.02 Development of Machine Learning Model to Estimate Overall Survival in Patients with Advanced NSCLC and ECOG-PS > 1 Open
View article: Letter to the editor: radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers
Letter to the editor: radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers Open
A commentary on the original research article: ‘Radiomics analysis for predicting pembrolizumab response in patients with advanced rare cancers’. Of note, the predictor selection process, the cross-validation method, along with the lack of…
View article: In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection
In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection Open
BAG S53P4 presented antibacterial properties as much as antibiotic-loaded PMMA for MDR bacteria producing OM and PJI.
View article: In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection
In vitro antibacterial activity of bioactive glass S53P4 on multiresistant pathogens causing osteomyelitis and prosthetic joint infection Open
Background Conventional local treatment for medullary osteomyelitis (OM) includes insertion of antibiotic-loaded polymethylmethacrylate (PMMA) cement. Nevertheless, PMMA may delivery irregular concentration of antibiotic to surrounding tis…