Mateusz Hess
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View article: A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations
A Tailored Phospho‐p53 Library Probes Antibody Specificity and Recognition Limitations Open
The tumor suppressor protein p53, known as the “guardian of the genome,” is regulated by a complex network of post‐translational modifications. Phosphorylations at 7 Ser/Thr residues within the N‐terminal transactivation domain 1 (TAD1) pl…
View article: Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse
Semisynthesis reveals apoptin as a tumour-selective protein prodrug that causes cytoskeletal collapse Open
Structure-activity studies with site-specifically modified apoptin in living cells demonstrate that this protein's toxicity is mediated by phosphorylation and downstream interactions with the cytoskeleton.
View article: Heterologous Systemic Prime–Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters
Heterologous Systemic Prime–Intranasal Boosting Using a Spore SARS-CoV-2 Vaccine Confers Mucosal Immunity and Cross-Reactive Antibodies in Mice as well as Protection in Hamsters Open
Background: Current severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines are administered systemically and typically result in poor immunogenicity at the mucosa. As a result, vaccination is unable to reduce viral shedding …
View article: Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance
Environmentally Acquired Bacillus and Their Role in C. difficile Colonization Resistance Open
Clostridioides difficile is an environmentally acquired, anaerobic, spore-forming bacterium which ordinarily causes disease following antibiotic-mediated dysbiosis of the intestinal microbiota. Although much is understood regarding the lif…
View article: Micellar Antibiotics of Bacillus
Micellar Antibiotics of Bacillus Open
Members of the Bacillus genus, particularly the “Bacillus subtilis group”, are known to produce amphipathic lipopeptides with biosurfactant activity. This includes the surfactins, fengycins and iturins that have been associated with antiba…