Mathan Kumar Ramasubbu
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View article: Assessment of response to total neoadjuvant therapy in carcinoma rectum: A real-world prospective observational study from eastern India
Assessment of response to total neoadjuvant therapy in carcinoma rectum: A real-world prospective observational study from eastern India Open
Background: Preoperative chemoradiotherapy and subsequent surgery is the standard of care for locally advanced rectal cancer. This has resulted in good local control, but without a significant survival benefit. Multiple randomised trials h…
View article: Applying quantitative and systems pharmacology to drug development and beyond: An introduction to clinical pharmacologists
Applying quantitative and systems pharmacology to drug development and beyond: An introduction to clinical pharmacologists Open
Quantitative and systems pharmacology (QSP) is an innovative and integrative approach combining physiology and pharmacology to accelerate medical research. This review focuses on QSP’s pivotal role in drug development and its broader appli…
View article: Dexmedetomidine for reducing succinylcholine-induced myalgia in patients undergoing electroconvulsive therapy: A randomised controlled trial.
Dexmedetomidine for reducing succinylcholine-induced myalgia in patients undergoing electroconvulsive therapy: A randomised controlled trial. Open
A low dose of dexmedetomidine (0.25 µg/kg) effectively reduces myalgia and fasciculations due to succinylcholine in patients undergoing electroconvulsive therapy.
View article: A comparative study in left-sided breast cancer treated with moderate deep inspiratory breath hold versus free breathing
A comparative study in left-sided breast cancer treated with moderate deep inspiratory breath hold versus free breathing Open
Background The moderate deep inspiratory breath hold (mDIBH) is a modality famed for cardiac sparing. Prospective studies based on this are few from the eastern part of the world and India. We intend to compare the dosimetry between mDIBH …
View article: Factors affecting the dosimetry of high-dose rate intracavitary brachytherapy in cervical cancer
Factors affecting the dosimetry of high-dose rate intracavitary brachytherapy in cervical cancer Open
Background: Intracavitary brachytherapy (ICBT) is essential in managing locally advanced cervical cancer. Brachytherapy as a modality has the advantage of a higher dose to the tumour with a dose fall off at the periphery as per the inverse…
View article: Does indirect decompression by oblique lateral interbody fusion produce similar clinical and radiological outcomes to direct decompression by open transforaminal lumbar interbody fusion
Does indirect decompression by oblique lateral interbody fusion produce similar clinical and radiological outcomes to direct decompression by open transforaminal lumbar interbody fusion Open
Objectives: Open transforaminal lumbar interbody fusion (O-TLIF) remains the most popular and widely practiced lumbar fusion method even today, providing direct decompression. Oblique lateral interbody fusion (OLIF) is a novel retroperiton…
View article: 144P Correlation of EZH2 expression and response to chemoradiotherapy in patients with locally advanced inoperable oral cavity and oropharyngeal squamous cell cancers
144P Correlation of EZH2 expression and response to chemoradiotherapy in patients with locally advanced inoperable oral cavity and oropharyngeal squamous cell cancers Open
Head and neck cancer (HNC) is a major global health concern. Despite advances in treatment, the outcome is poor due to locoregional failure. Therefore, there is an urgent need to identify molecular markers that can predict recurrence and t…