Mathew Upton
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View article: Assessing a penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation reporting healthcare workers’ experiences
Assessing a penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation reporting healthcare workers’ experiences Open
Background and objectives Penicillin allergy (penA) records prevent first-line penicillin antibiotic use, but more than 90% are incorrect after formal testing and can be removed (‘de-labelled’). We developed an implementation intervention …
View article: Penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation, the patient experience
Penicillin allergy de-labelling implementation intervention in a UK hospital: a process evaluation, the patient experience Open
Background Penicillin allergy (penA) records are common, but true penA is rare. PenA records are associated with broad spectrum antibiotic prescribing and negative patient outcomes. We developed a behavioural intervention package to suppor…
View article: Description of the combined evidence-based, theory-based and person-based approaches used to develop a behavioural intervention package to support non-allergist healthcare workers to remove incorrect penicillin allergy records from medical and surgical adult inpatients in a UK hospital
Description of the combined evidence-based, theory-based and person-based approaches used to develop a behavioural intervention package to support non-allergist healthcare workers to remove incorrect penicillin allergy records from medical and surgical adult inpatients in a UK hospital Open
Objectives To develop a behavioural intervention package to support non-allergist healthcare workers (HCWs) to remove incorrect penA records from medical and surgical adult inpatients. This paper describes the development of the penicillin…
View article: Epidermicin NI01, a First-in-Class Peptide Antibiotic Candidate, Has Potent Efficacy in a Robust MRSA Wound Infection Model and Low Allergic Reaction Liabilities
Epidermicin NI01, a First-in-Class Peptide Antibiotic Candidate, Has Potent Efficacy in a Robust MRSA Wound Infection Model and Low Allergic Reaction Liabilities Open
View article: Genomic insights and phenotypic characterization of three multidrug resistant <i>Cupriavidus</i> strains from the cystic fibrosis lung
Genomic insights and phenotypic characterization of three multidrug resistant <i>Cupriavidus</i> strains from the cystic fibrosis lung Open
Aims We aimed to investigate phenotypic and genomic traits of three Cupriavidus spp. isolates recovered from people with cystic fibrosis (PWCF). These bacteria are recognized as emerging pathogens in PWCF. Methods and results Using short a…
View article: Impact of growth conditions on the abundance and diversity of cultivable bacteria recovered from <i>Pheronema carpenteri</i> and investigation of their antimicrobial potential
Impact of growth conditions on the abundance and diversity of cultivable bacteria recovered from <i>Pheronema carpenteri</i> and investigation of their antimicrobial potential Open
The deep sea is a largely unexplored extreme environment supporting a diverse biological community adapted to low temperatures and high pressures. Such environments support microbial life that may be a source of novel antibiotics and other…
View article: Psychrotrophic Antarctic marine bacteria as potential reservoirs for novel antimicrobial genes
Psychrotrophic Antarctic marine bacteria as potential reservoirs for novel antimicrobial genes Open
Antarctica is a very cold, isolated continent surrounded by frozen seas, yet these extreme environmental conditions have not restricted life and diversity in the sea. The marine environment is seasonally highly productive and harbours dive…
View article: Editorial: Bacteriocins and other ribosomally synthesised and post-translationally modified peptides (RiPPs) as modulators of the microbiome
Editorial: Bacteriocins and other ribosomally synthesised and post-translationally modified peptides (RiPPs) as modulators of the microbiome Open
Editorial: Bacteriocins and other ribosomally synthesised and post-translationally modified peptides (RiPPs) as modulators of the microbiome
View article: Evaluating the antibacterial efficacy of a silver nanocomposite surface coating against nosocomial pathogens as an antibiofilm strategy to prevent hospital infections
Evaluating the antibacterial efficacy of a silver nanocomposite surface coating against nosocomial pathogens as an antibiofilm strategy to prevent hospital infections Open
Antimicrobial nanocoatings may be a means of preventing nosocomial infections, which account for significant morbidity and mortality. The role of hospital sink traps in these infections is also increasingly appreciated. We describe the pre…
View article: Immunogenicity and Protective Capacity of Sugar ABC Transporter Substrate-Binding Protein against Streptococcus suis Serotype 2, 7 and 9 Infection in Mice
Immunogenicity and Protective Capacity of Sugar ABC Transporter Substrate-Binding Protein against Streptococcus suis Serotype 2, 7 and 9 Infection in Mice Open
Background: Streptococcus suis (S. suis) is a Gram-positive bacterium that causes substantial disease in pigs. S. suis is also an emerging zoonoses in humans, primarily in Asia, through the consumption of undercooked pork and the handling …
View article: Physicochemical and metagenomic analysis of samples from the Roman Baths (Bath, UK) reveals high bacterial and archaeal diversity and a potential for antimicrobial discovery
Physicochemical and metagenomic analysis of samples from the Roman Baths (Bath, UK) reveals high bacterial and archaeal diversity and a potential for antimicrobial discovery Open
Antimicrobial resistance of pathogenic bacteria to currently used antibiotics killed an estimated 1.27 million people in 2019 and it is believed that this toll will increase to 10 million per year by 2050. This remains one of the most urge…
View article: Non-allergist healthcare workers views on delivering a penicillin allergy de-labelling inpatient pathway: identifying the barriers and enablers
Non-allergist healthcare workers views on delivering a penicillin allergy de-labelling inpatient pathway: identifying the barriers and enablers Open
Background Non-allergist delivered PADL is supported by UK and World Health Organization guidelines but is not yet routine in UK hospitals. Understanding the views of healthcare workers (HCWs) on managing patients with penA records and exp…
View article: Experiences of an inpatient penicillin allergy de-labelling pathway: capturing the patient voice
Experiences of an inpatient penicillin allergy de-labelling pathway: capturing the patient voice Open
Background Non-allergist-delivered penicillin allergy de-labelling (PADL) is supported by UK and other national guidelines but is not yet routine practice in UK hospitals. Those who have undergone PADL report high rates of acceptance, but …
View article: Urinary tract infections: a review of the current diagnostics landscape
Urinary tract infections: a review of the current diagnostics landscape Open
Urinary tract infections are the most common bacterial infections worldwide. Infections can range from mild, recurrent (rUTI) to complicated (cUTIs), and are predominantly caused by uropathogenic Escherichia coli (UPEC). Antibiotic therapy…
View article: Bovine Herpesvirus-4 Based Vaccine Provides Protective Immunity against Streptococcus suis Disease in a Rabbit Model
Bovine Herpesvirus-4 Based Vaccine Provides Protective Immunity against Streptococcus suis Disease in a Rabbit Model Open
Streptococcus suis (S. suis) is a bacterial pathogen of pigs that has a major animal health and economic impact on the pig industry. Bovine herpesvirus-4 (BoHV-4) is a new virus-based vaccine vector that has been used for the immunogenic d…
View article: Review of Antimicrobial Nanocoatings in Medicine and Dentistry: Mechanisms of Action, Biocompatibility Performance, Safety, and Benefits Compared to Antibiotics
Review of Antimicrobial Nanocoatings in Medicine and Dentistry: Mechanisms of Action, Biocompatibility Performance, Safety, and Benefits Compared to Antibiotics Open
This review discusses topics relevant to the development of antimicrobial nanocoatings and nanoscale surface modifications for medical and dental applications. Nanomaterials have unique properties compared to their micro- and macro-scale c…
View article: Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Streptococcus suis Serotype 2, 7, and 9 in Mice
Subunit Vaccine Targeting Phosphate ABC Transporter ATP-Binding Protein, PstB, Provides Cross-Protection against Streptococcus suis Serotype 2, 7, and 9 in Mice Open
Streptococcus suis is a significant pathogen in pigs and a newly emerging zoonotic agent in humans. The presence of multiple serotypes and strains with diversified sequence types in pig herds highlights the need for the identification of b…
View article: Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential
Whole genomes of deep-sea sponge-associated bacteria exhibit high novel natural product potential Open
Global antimicrobial resistance is a health crisis that can change the face of modern medicine. Exploring diverse natural habitats for bacterially-derived novel antimicrobial compounds has historically been a successful strategy. The deep-…
View article: Is penicillin allergy de-labelling about to find its place in UK antimicrobial stewardship strategy?
Is penicillin allergy de-labelling about to find its place in UK antimicrobial stewardship strategy? Open
View article: Physicochemical and Metagenomic Analysis of Samples from the Roman Baths (Bath, UK) Reveals High Bacterial and Archaeal Diversity and a Potential for Antimicrobial Discovery
Physicochemical and Metagenomic Analysis of Samples from the Roman Baths (Bath, UK) Reveals High Bacterial and Archaeal Diversity and a Potential for Antimicrobial Discovery Open
View article: The effectiveness of interventions that support penicillin allergy assessment and delabeling of adult and pediatric patients by nonallergy specialists: a systematic review and meta-analysis
The effectiveness of interventions that support penicillin allergy assessment and delabeling of adult and pediatric patients by nonallergy specialists: a systematic review and meta-analysis Open
View article: Hospital sink traps as a potential source of the emerging multidrug-resistant pathogen Cupriavidus pauculus: characterization and draft genome sequence of strain MF1
Hospital sink traps as a potential source of the emerging multidrug-resistant pathogen Cupriavidus pauculus: characterization and draft genome sequence of strain MF1 Open
Introduction. Cupriavidus pauculus is historically found in soil and water but has more recently been reported to cause human infection and death. Hospital sink traps can serve as a niche for bacterial persistence and a platform for horizo…
View article: Impact of growth media and pressure on the diversity and antimicrobial activity of isolates from two species of hexactinellid sponge
Impact of growth media and pressure on the diversity and antimicrobial activity of isolates from two species of hexactinellid sponge Open
Access to deep-sea sponges brings with it the potential to discover novel antimicrobial candidates, as well as novel cold- and pressure-adapted bacteria with further potential clinical or industrial applications. In this study, we implemen…
View article: Effectiveness of interventions that support penicillin allergy assessment and de-labeling of patients by non-allergy specialists: a systematic review protocol
Effectiveness of interventions that support penicillin allergy assessment and de-labeling of patients by non-allergy specialists: a systematic review protocol Open
Objective: This review will systematically examine and synthesize the evidence evaluating the effectiveness and safety of interventions that enable non-allergy specialist health care workers to assess allergy risk in patients with reported…
View article: COVID sex lives : survey 1 report
COVID sex lives : survey 1 report Open
This report presents initial findings from the first survey of Covid Sex Lives project. Public health
\nmeasures to mitigate the spread of coronavirus are translated into media messaging by
\norganisations that target the health of differe…
View article: Editorial: Bacteriocins and Other Ribosomally Synthesised and Post-translationally Modified Peptides (RiPPs) as Alternatives to Antibiotics
Editorial: Bacteriocins and Other Ribosomally Synthesised and Post-translationally Modified Peptides (RiPPs) as Alternatives to Antibiotics Open
This Research Topic concerns bacteriocins and others RiPPs (Ribosomally synthesized and\nPost-translationally modified Peptides) as alternatives to antibiotics. Due to the increasing problem\nof antibiotic resistance globally, there is a p…
View article: The Phylogenetic Structure of Reptile, Avian and Uropathogenic Escherichia coli with Particular Reference to Extraintestinal Pathotypes
The Phylogenetic Structure of Reptile, Avian and Uropathogenic Escherichia coli with Particular Reference to Extraintestinal Pathotypes Open
The impact of the Gram-negative bacterium Escherichia coli (E. coli) on the microbiomic and pathogenic phenomena occurring in humans and other warm-blooded animals is relatively well-recognized. At the same time, there are scant data conce…
View article: <i>Galleria mellonella</i> larvae exhibit a weight-dependent lethal median dose when infected with methicillin-resistant <i>Staphylococcus aureus</i>
<i>Galleria mellonella</i> larvae exhibit a weight-dependent lethal median dose when infected with methicillin-resistant <i>Staphylococcus aureus</i> Open
Galleria mellonella is a recognised model to study antimicrobial efficacy; however, standardisation across the scientific field and investigations of methodological components are needed. Here, we investigate the impact of weight on mortal…
View article: Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria
Drug repurposing for next-generation combination therapies against multidrug-resistant bacteria Open
Antimicrobial resistance has been a global health challenge that threatens our ability to control and treat life-threatening bacterial infections. Despite ongoing efforts to identify new drugs or alternatives to antibiotics, no new classes…
View article: Flowering Poration—A Synergistic Multi-Mode Antibacterial Mechanism by a Bacteriocin Fold
Flowering Poration—A Synergistic Multi-Mode Antibacterial Mechanism by a Bacteriocin Fold Open