Mathias Bernhardt
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Loss of tumorigenic potential upon transdifferentiation from keratinocytic into melanocytic lineage Open
Lineage-specific transcription factors determine the cell fate during development. Direct conversion of several cell types into other lineages has been achieved by the overexpression of specific transcription factors. Even cancer cells hav…
SOX5 is involved in balanced MITF regulation in human melanoma cells Open
MITF regulation by SOX5 has been shown only in murine cells, but not yet in human melanoma cells. SOX5 has a strong inhibitory effect on MITF expression and seems to have a decisive clinical impact on melanoma during tumor progression.
Directed Dedifferentiation Using Partial Reprogramming Induces Invasive Phenotype in Melanoma Cells Open
The combination of cancer-focused studies and research related to nuclear reprogramming has gained increasing importance since both processes—reprogramming towards pluripotency and malignant transformation—share essential features. Studies…