Mathias Lichterfeld
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View article: Viral reservoir characteristics in lymphoid tissues of HIV-1 elite controllers
Viral reservoir characteristics in lymphoid tissues of HIV-1 elite controllers Open
Elite controllers (ECs) maintain undetectable levels of plasma viremia in the absence of treatment, but small reservoirs of replication-competent proviruses persist in the vast majority of these persons. We longitudinally studied paired bl…
View article: Factors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodies
Factors associated with resistance of HIV-1 reservoir viruses to neutralization by autologous IgG antibodies Open
BACKGROUNDAntiretroviral therapy (ART) prevents HIV-1 replication but does not eliminate the latent reservoir, the source of viral rebound if treatment is stopped. Autologous neutralizing antibodies (aNAbs) can block in vitro outgrowth of …
View article: Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection
Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection Open
Persisting HIV reservoir viruses in resting CD4 T cells and other cellular subsets are a barrier to cure efforts. Early antiretroviral therapy (ART) enables post-treatment viral control in some cases, but mechanisms remain unclear. We hypo…
View article: Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection
Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection Open
Background Persisting HIV reservoir viruses in resting CD4 T cells and other cellular subsets are the main barrier to cure efforts. Antiretroviral therapy (ART) intensification by early initiation has been shown to enable post-treatment vi…
View article: Profound reduction of HIV-1 reservoir cells over 3 decades of antiretroviral therapy started in early infancy
Profound reduction of HIV-1 reservoir cells over 3 decades of antiretroviral therapy started in early infancy Open
HIV-1 reservoir cells persist indefinitely during suppressive antiretroviral therapy (ART) in individuals who acquire infection in adulthood, but little is known about the longitudinal evolution of viral reservoir cells during long-term AR…
View article: Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection
Footprints of innate immune activity during HIV-1 reservoir cell evolution in early-treated infection Open
Antiretroviral treatment (ART) initiation during the early stages of HIV-1 infection is associated with a higher probability of maintaining drug-free viral control during subsequent treatment interruptions, for reasons that remain unclear.…
View article: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? Open
Once a death sentence, HIV is now considered a manageable chronic disease due to the development of antiretroviral therapy (ART) regimens with minimal toxicity and a high barrier for genetic resistance. While highly effective in arresting …
View article: Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? Open
[This corrects the article DOI: 10.20411/pai.v8i2.665.].
View article: Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection
Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection Open
Background Persisting HIV reservoir viruses in resting CD4 T cells and other cellular subsets are the main barrier to cure efforts. Antiretroviral therapy (ART) intensification by early initiation has been shown to enable post-treatment vi…
View article: Vedolizumab and ART in recent HIV-1 infection unveil the role of α4β7 in reservoir size
Vedolizumab and ART in recent HIV-1 infection unveil the role of α4β7 in reservoir size Open
BACKGROUNDWe evaluated the safety and viral rebound, after analytical treatment interruption (ATI), of vedolizumab and ART in recent HIV-1 infection. We used this model to analyze the effect of α4β7 on the HIV-1 reservoir size.METHODSParti…
View article: High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries
High mortality following early initiation of antiretroviral therapy in infants living with HIV from three African countries Open
Early Treated Perinatally HIV Infected Individuals: Improving Children's Actual Life (EPIICAL) is a research consortium funded by ViiV Healthcare and led by Penta Foundation. The funder was not involved in the analysis and interpretation o…
View article: Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection
Differences in HIV-1 reservoir size, landscape characteristics, and decay dynamics in acute and chronic treated HIV-1 Clade C infection Open
Persisting HIV reservoir viruses in resting CD4 T cells and other cellular subsets are a barrier to cure efforts. Early antiretroviral therapy (ART) enables post-treatment viral control in some cases, but mechanisms remain unclear. We hypo…
View article: Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection
Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection Open
Background Persisting HIV reservoir viruses in resting CD4 T cells and other cellular subsets are the main barrier to cure efforts. Antiretroviral therapy (ART) intensification by early initiation has been shown to enable post-treatment vi…
View article: Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? Open
Erratum to: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? doi: 10.20411/pai.v8i2.665 In the original publication, the comments provided by Santiago Ávila-Ríos were mistakenly omitted. In this version, his co…
View article: Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner?
Progress Note 2024: Curing HIV; Not in My Lifetime or Just Around the Corner? Open
Once a death sentence, HIV is now considered a manageable chronic disease due to the development of antiretroviral therapy (ART) regimens with minimal toxicity and a high barrier for genetic resistance. While highly effective in arresting …
View article: The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers
The HIV-1 reservoir landscape in persistent elite controllers and transient elite controllers Open
BACKGROUNDPersistent controllers (PCs) maintain antiretroviral-free HIV-1 control indefinitely over time, while transient controllers (TCs) eventually lose virological control. It is essential to characterize the quality of the HIV reservo…
View article: Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection
Differences in HIV-1 reservoir size, landscape characteristics and decay dynamics in acute and chronic treated HIV-1 Clade C infection Open
Background Persisting HIV reservoir viruses in resting CD4 T cells and other cellular subsets are the main barrier to cure efforts. Antiretroviral therapy (ART) intensification by early initiation has been shown to enable post-treatment vi…
View article: Proliferation of HIV-1 reservoir cells: The delusion of infinite growth
Proliferation of HIV-1 reservoir cells: The delusion of infinite growth Open
Proliferation of HIV-1–infected cells contributes to viral persistence despite antiretroviral therapy. A new study by Kufera et al. (https://doi.org/10.1084/jem.20231511) demonstrates that proliferative growth of cells infected with genome…
View article: Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a
Selection of epigenetically privileged HIV-1 proviruses during treatment with panobinostat and interferon-α2a Open
CD4+ T cells with latent HIV-1 infection persist despite treatment with antiretroviral agents and represent the main barrier to a cure of HIV-1 infection. Pharmacological disruption of viral latency may expose HIV-1-infected cells to host …